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01-09-2018 | Review

Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis

Authors: Jonathan Meza-Mauricio, David Soto-Peñaloza, David Peñarrocha-Oltra, Jose Maria Montiel-Company, Daiane Cristina Peruzzo

Published in: Clinical Oral Investigations | Issue 7/2018

Abstract

Objective

This review aimed at evaluating the effects of chronic periodontitis (CP) treatment with local statins as adjuncts to scaling and root planing (SRP), compared with SRP alone or with placebo.

Methods

Electronic and hand searches were conducted in three databases to select randomized controlled trials (RCTs) comparing SRP + statins versus SRP alone. Random effects models were conducted to determine the clinical attachment level (CAL) gain as the primary outcome variable, and probing pocket depth (PPD) reduction, modified sulcus bleeding index (mSBI), and intrabony defect depth (IBD) as the secondary outcomes.

Results

Of the 526 papers identified, 15 articles met the criteria for inclusion in this systematic review, and 13 in the meta-analysis. The meta-analysis showed a statistically significant CAL gain (mean differences [MD] = 1.84 mm, 95% confidence interval [CI] = 1.45 to 2.23; p = 0.000), PPD reduction (MD = 1.69 mm, 95% CI = 1.37 to 2.04; p = 0.000), mSBI change (MD = 0.70, 95% CI = 0.57 to 0.84; p = 0.000), and IBD (MD = 1.48, 95% CI = 1.30 to 1.67; p = 0.000) attributed to SRP + statin treatment (6 months).

Conclusion

Within the limitations of this study, the collective evidence emerging from this systematic review and meta-analysis may support the use of locally applied statins as adjuncts to SRP in CP treatment, based on being an easy, low-cost alternative, with lesser adverse effects on bacterial resistance. These results should be interpreted with caution.

Clinical relevance

Clinicians might consider the use of SRP + statins as an adjunct over other alternative approaches, based on the results of the present review. The informed decision should be taken, considering the patient’s values and preferences, and the intervention to be implemented by the clinician.

Available only for authorised users

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Title: Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis
Authors: Jonathan Meza-Mauricio
David Soto-Peñaloza
David Peñarrocha-Oltra
Jose Maria Montiel-Company
Daiane Cristina Peruzzo
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 7/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2507-x

At a glance: The STEP trials

Springer Medicine

Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

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