Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Head and Neck Pathology
Published in: Head and Neck Pathology 4/2018

01-12-2018 | Review Paper

Localized Nasopharyngeal Amyloidosis: A Clinicopathologic Series of 7 Cases with a Literature Review

Authors: Georgios Sakagiannis, Evangelos Giotakis, Lester D. R. Thompson

Published in: Head and Neck Pathology | Issue 4/2018

Login to get access

Abstract

Localized nasopharyngeal amyloidosis is an extremely rare entity with only 25 cases described in the English and German literature. We present a case series of seven patients with localized nasopharyngeal amyloidosis and combine the findings with a thorough review the literature.
Literature
1.
Sipe JD, Benson MD, Buxbaum JN, Ikeda SI, Merlini G, Saraiva MJ, Westermark P. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines. Amyloid. 2016;23(4):209–13.CrossRef
2.
Nienhuis HL, Bijzet J, Hazenberg BP. The prevalence and management of systemic amyloidosis in Western Countries. Kidney Dis. 2016;2(1):10–9.CrossRef
3.
Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, Westermark P. Nomenclature 2014: amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid. 2014;21:221–4.CrossRef
4.
Hazenberg BP. Amyloidosis: a clinical overview. Rheum Dis Clin North Am. 2013;39:323–45.CrossRef
5.
Glenner GG. Amyloid deposits and amyloidosis: the beta-fibrilloses. N Engl J Med. 1980;302:1283–92, 1333–43.CrossRef
6.
Scott PP, Scott WW, Siegelman SS. Amyloidosis: an overview. SeminRoentgenol. 1986;21:103–12.
7.
Panda N, Saravanan K, Purushotaman G, Gurunathan R, Mahesha V. Localized amyloidosis masquerading as nasopharyngeal tumor: a review. Am J Otolaryngol-Head Neck Surg. 2007;28:208–11.
8.
Yoshida A, Borkar S, Singh B, Ghossein RA. Schöder H Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F] fluorodeoxyglucose positron emission tomography/computed tomography. J Clin Oncol. 2008;26(35):5817–9.CrossRef
9.
Kramer R, Som ML. Local tumor-like deposits of amyloid in thelarynx. Report of a case and review of the literature. Arch Otolaryngol 1935;21:324–34.CrossRef
10.
Johner CH, Widen AH, Soghol S. Amyloidosis of the head and neck. Trans Pa Acad Ophthalmol Otol. 1972;76:1354–5.
11.
Simpson GT, Strong MS, Skinner M, et al. Localized amyloidosis of the head and neck, upper and lower respiratory tracts. Ann OtolRhinol Laryngol. 1984;93:374–9.CrossRef
12.
Zack Zonk MS. Unusual etiology of unilateral glue ear in a child. J Laryngol Otol. 1984;98:519–22.
13.
Gean-Marton AD, Clandia FE, Kirsch BS, et al. Focal amyloidosis of the head and neck: evaluation with CT and MR imaging. Radiology. 1991;181:521–5.CrossRef
14.
Hegarty JL, Rao VM. Amyloidoma of the nasopharynx: CT and MR findings. AJNR Am J Neuroradiol. 1993;114:215–8.
15.
Panda NK, Sharma SC, Mann SB, et al. Localized amyloidosis of the nasopharynx. ENT J. 1994;75:335–6.
16.
Dominguez S, Wienberg P, Claros P, et al. Primary localized nasopharyngeal amyloidosis. A case report. Int J Pediatr Otorhinolaryngol. 1996;36:61–7.CrossRef
17.
Lim JS, Lebowitz RA, Jacob JB. Primary amyloidosis presenting as a nasopharyngeal mass. Am J Rhinol. 1999;13:209–12.CrossRef
18.
Pitkaranta A, Malmberg H. Localized amyloid tumor of nasopharynx. Otolaryngol Head Neck Surg. 2000;122:309–10.CrossRef
19.
Munichor M, Cohen H, Kerner H, et al. Localized amyloidosis in nasopharyngeal carcinoma diagnosed by fine needle aspiration and electron microscopy. A case report. Acta Cytol. 2000;44:673–8.CrossRef
20.
Patel A, Pombuccian S, Maisel R. Nasopharyngeal amyloidosis. Am J Otolaryngol 2002;23:308–11.CrossRef
21.
Zhuang YL, Tsai TL, Lin CZ. Localized amyloid deposition in the nasopharynx and neck, mimicking nasopharyngeal carcinoma with neck metastasis. J Chin Med Assoc. 2005;68(3):142–5.CrossRef
22.
Motosugi U, Ichikawa T, Araki T, Endo S, Masuyama K, Nakazawa T. Localized nasopharyngeal amyloidosis with remarkable early enhancement on dynamic contrast-enhanced MR imaging. Eur Radiol. 2007;17(3):852–3.CrossRef
23.
Chen YS, Li WY, Ho CY. Localized nasopharyngeal amyloidosis. J Chin Med Assoc. 2010;73(10):549–52.CrossRef
24.
Wu AY, Chapman WB, Witterick IJ, Deangelis DD. Bifocal orbital and nasopharyngeal amyloidomas presenting as Graves disease. Ophthal Plast Reconstr Surg. 2011;27(5):e132–e4.CrossRef
25.
Karimi K, Chheda NN. Nasopharyngeal amyloidosis: a case report. Laryngoscope 2010;120(Suppl 4):S197.CrossRef
26.
Durbec M, Ambrun A, Barnoud R, Poupart M, Pignat JC, Merrot O. Localized nasopharyngeal amyloidosis. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129(3):160–2.CrossRef
27.
Legaza ES, Oliver CC, Cauqui RG. Amyloidosis of the nasopharynx. Acta Otorrinolaringol Esp. 2013;64(5):377–8.CrossRef
28.
Mirza AH, El-Shunnar S, Sama A. Nasopharyngeal amyloidosis: an unusual cause of unilateral hearing loss. J Surg Case Rep. 2013;2013(2):rjs048.CrossRef
29.
Kumar B, Pant B, Kumar V, Negi M. Sinonasal globular amyloidosis simulating malignancy: a rare presentation. Head Neck Pathol. 2016;10(3):379–83.CrossRef
30.
Luo M, Peng G, Shi L, Ming X, Li Z, Fei S, Ding Q, Cheng J. Intensity-modulated radiotherapy for localized nasopharyngeal amyloidosis: case report and literature review. Strahlenther Onkol. 2016;192(12):944–50.CrossRef
31.
Urban BA, Fishman EK, Goldman SM, Scott WW, Jones B, Humphrey RL, Hruban RH. CT evaluation of amyloidosis: spectrum of disease. Radiographics 1993;13:1295–308.CrossRef
32.
Nandapalan V, Jones TM, Morar P, Clark AH, Jones AS. Localized amyloidosis of the parotid gland: a case report and review of the localized amyloidosis of the head and neck. Head Neck. 1998;20(1):73–8.CrossRef
Metadata
Title
Localized Nasopharyngeal Amyloidosis: A Clinicopathologic Series of 7 Cases with a Literature Review
Authors
Georgios Sakagiannis
Evangelos Giotakis
Lester D. R. Thompson
Publication date
01-12-2018
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 4/2018
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-017-0880-4

Other articles of this Issue 4/2018

Head and Neck Pathology 4/2018 Go to the issue

Sine qua non Radiology-Pathology

Juvenile Trabecular Ossifying Fibroma

Case Report

A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris

Letter to the Editor

Regarding the Use of the Term “Cementum” in Fibro-Osseous Lesions of the Craniofacial Skeleton

Sine qua non Clinicopathologic Correlation

Adenosquamous Carcinoma of the Tongue

Original Paper

LEF-1 is a Sensitive Marker of Cribriform Morular Variant of Papillary Thyroid Carcinoma

Case Report

Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy