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Annals of Hematology
Published in: Annals of Hematology 5/2005

01-05-2005 | Original Article

Local umbilical cord blood renin–angiotensin system

Authors: Hakan Goker, Ibrahim C. Haznedaroglu, Yavuz Beyazit, Salih Aksu, Serdar Tuncer, Muge Misirlioglu, Fatma Bayramoglu, Murat Kekilli, Yahya Büyükasik, Nilgun Sayinalp, Osman Ozcebe, Semra Dundar, Leyla Mollamahmutoglu

Published in: Annals of Hematology | Issue 5/2005

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Abstract

Local bone marrow (BM) renin–angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin II type 1a (AT1a) receptors are present on the CD34+ hematopoietic stem cells (HSC). Angiotensin II stimulates the proliferation and differentiation of the HSC populations through the activation of AT1 receptors on HSC. Umbilical cord blood (UCB) is a rich source of HSC. The existence of a complete local UCB RAS has not been previously investigated. In this study, local synthesis of the major RAS components, namely, angiotensin-converting enzyme (ACE), renin, and angiotensinogen, was identified by demonstrating their corresponding mRNAs using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in human UCB. Local RAS could regulate cellular growth in a variety of tissues including the BM. Major RAS peptides can exert significant effects on primitive pluripotential HSC populations. Further studies should focus on the interactions between possible autocrine, paracrine, endocrine, and intracrine actions of the local UCB RAS and growth, engraftment, differentiation, and plasticity functions of HSC of UCB origin.
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Metadata
Title
Local umbilical cord blood renin–angiotensin system
Authors
Hakan Goker
Ibrahim C. Haznedaroglu
Yavuz Beyazit
Salih Aksu
Serdar Tuncer
Muge Misirlioglu
Fatma Bayramoglu
Murat Kekilli
Yahya Büyükasik
Nilgun Sayinalp
Osman Ozcebe
Semra Dundar
Leyla Mollamahmutoglu
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 5/2005
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-004-0989-x

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