Top

Published in:

01-07-2006 | Original Article

Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma

Authors: Tsukasa Wada, Kiyoshi Kuroda, Yuki Yoshida, Kuniaki Ogasawara, Akira Ogawa, Shigeatsu Endo

Published in: Neurosurgical Review | Issue 3/2006

Abstract

We investigated the relationship between inflammatory and anti-inflammatory cytokines in the pathogenesis of chronic subdural hematoma (CSDH) by measuring the plasma and subdural fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). The levels of IL-6, IL-8 and IL-10 were measured in the subdural fluid obtained from 34 patients with CSDH, using the enzyme-linked immunosorbent assay. The patients were classified into a high IL-10 group and a low IL-10 group according to the level of IL-10 in their subdural fluid samples. The subdural fluid levels of IL-6 and IL-8 were significantly higher in the high IL-10 group than in the low IL-10 group (P<0.05). A tendency for the patients in the low IL-10 group to show the separated or layer type of pattern on the CT scans was noted.

Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397–440CrossRefPubMed

Frati A, Salvati M, Mainiero F, Ippolity F, Rocchi G, Raco A, Caroli E, Cantore G, Delfini R (2004) Inflammation markers and risk factors for recurrence in 35 patients with a posttraumatic chronic subdural hematoma: a prospective study. J Neurosurg 100:24–32PubMed

Fujisawa H, Ito H, Saito K, Ikeda K, Nitta H, Yamashita J (1991) Immunohistochemical localization of tissue-type plasminogen activator in the lining wall of chronic subdural hematoma. Surg Neurol 35:441–445CrossRefPubMed

Fujisawa H, Ito H, Kashiwagi S, Nomura S, Toyosawa M (1995) Kallikrein-kinin system in chronic subdural haematomas: its roles in vascular permeability and regulation of fibrinolysis and coagulation. J Neurol Neurosurg Psychiatry 59:388–394PubMedCrossRef

Fujisawa H, Nomura S, Tsuchida E, Ito H (1998) Serum protein exudation in chronic subdural haematomas: a mechanism for haematoma enlargement? Acta Neurochir 140:161–166CrossRef

Gardner WJ (1932) Traumatic subdural hematoma. With particular reference to the latent interval. Arch Neurol Psychiatry 27:847–858

Goodell CL, Mealey J Jr (1963) Pathogenesis of chronic subdural hematoma. Experimental studies. Arch Neurol 8:429–437PubMed

Haines DE (1991) On the question of a subdural space. Anat Rec 230:3–21CrossRefPubMed

Haines DE, Harkey HL, al-Mefty O (1993) The “subdural” space: a new look at an outdated concept. Neurosurgery 32:111–120PubMedCrossRef

10.

Hirashima Y, Endo S, Hayashi N, Karasawa K, Nojima S, Takaku A (1995) Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers. Acta Neurochir 137:15–18CrossRef

11.

Hirasima Y, Endo S, Kato R, Ohmori T, Nagahori T, Nishijima M, Karasawa K, Nojima S, Takaku A (1994) Platelet-activating factor (PAF) and the development of chronic subdural haematoma. Acta Neurochir 129:20–25CrossRef

12.

Ito H, Saito K, Yamamoto S, Hasegawa T (1988) Tissue-type plasminogen activator in the chronic subdural hematoma. Surg Neurol 30:175–179CrossRefPubMed

13.

Markwalder TM (1981) Chronic subdural hematomas: a review. J Neurosurg 54:637–645PubMed

14.

Markwalder TM, Steinsiepe KF, Rohner M, Reichenbach W, Markwalder H (1981) The course of chronic subdural haematoma after burr-hole craniostomy and closed-system drainage. J Neurosurg 55:390–396PubMed

15.

Nakaguchi H, Tanishima T, Yoshimasu N (2000) Relationship between drainage catheter location and postoperative recurrence of chronic subdural hematoma after burr-hole irrigation and closed-system drainage. J Neurosurg 93:791–795PubMedCrossRef

16.

Nakamura S, Tsubokawa T (1989) Extraction of angiogenesis factor from chronic subdural haematomas. Significance in capsule formation and haematoma growth. Brain Inj 3:129–136PubMedCrossRef

17.

Nomura S, Kashiwagi S, Fujisawa H, Ito H, Nakamura K (1994) Characterization of local hyperfibrinolysis in chronic subdural hematoma by SDS-PAGE and innunoblot. J Neurosurg 81:910–913PubMedCrossRef

18.

Ross SA, Halliday MI, Campbell GC, Byrness DP, Rowlands BJ (1994) The presence of tumor necrosis factor in CSF and plasma after severe head injury. Br J Neurosurg 8:419–425PubMedCrossRef

19.

Seymour RM, Henderson B (2001) Pro-inflammatory-anti-inflammatory cytokine dynamics mediated by cytokine-receptor dynamics in monocytes. IMA J Math Appl Med 18:159–192CrossRef

20.

Suzuki M, Endo S, Inada K, Kudo A, Kitakami A, Kuroda K, Ogawa A (1998) Inflammatory cytokines locally elevated in chronic subdural haematoma. Acta Neurochir 140:51–55CrossRef

21.

Suzuki M, Kudo A, Kitakami A, Doi M, Kubo N, Kuroda K, Ogawa A (1998) Local hypercoagulative activity precedes hyperfibrinolytic activity in the subdural space during development of chronic subdural haematoma from subdural effusion. Acta Neurochir 140:261–266CrossRef

Title: Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma
Authors: Tsukasa Wada
Kiyoshi Kuroda
Yuki Yoshida
Kuniaki Ogasawara
Akira Ogawa
Shigeatsu Endo
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: Neurosurgical Review / Issue 3/2006
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-006-0019-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2006

The characteristics of the anterior communicating artery aneurysm complex by three-dimensional digital subtraction angiography

Hemispherectomy: a schematic review of the current techniques

Inflammatory pseudotumor of the cavernous sinus and skull base

Management of cerebral vasospasm

A pituitary abscess showing high signal intensity on diffusion-weighted imaging

Cirsoid aneurysms of the scalp