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European Radiology
Published in: European Radiology 9/2020

01-09-2020 | Liver Transplantation | Ultrasound

Combination of liver graft sonographic grading and point shear wave elastography to reduce early allograft dysfunction after liver transplantation

Authors: Wen-yi Liu, Xuan-xuan Li, Xiao-yue Fu, Xiao-dong Wu, Xin Wang, Yuan Guo, Yun-jin Zang, Jian-hong Wang

Published in: European Radiology | Issue 9/2020

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Abstract

Objective

To analyze the performance of a liver graft sonographic grading system and point shear wave elastography (PSWE) in predicting early allograft dysfunction (EAD) after liver transplantation (LT).

Methods

Successive brain-dead donors and liver recipients in our hospital from March 2017 to May 2018 were retrospectively recruited. All donors underwent PSWE examination, abdominal ultrasonography, and sonographic grading (grade 0 to grade 5). Donors with ≥ 10 valid PSWE examinations and a failure rate of < 60% were included. For all recipients, abdominal ultrasonography and blood tests for biologic parameters were performed preoperatively and daily postoperatively to screen for EAD. The recipients and their grafts were classified into EAD and non-EAD groups. Statistical analyses were performed to analyze the correlations among liver stiffness (LS), liver graft sonographic grading, and EAD.

Results

Thirty-two donors and 32 corresponding liver recipients were enrolled (15 cases in the EAD group; 17 in the non-EAD group). There were no grade 0, 1, or 2 cases in the two groups. For prediction of EAD in recipients after LT, the AUC for PSWE was 0.929 and the AUC for combination of PSWE and sonographic grading system was 0.935.

Conclusions

Combination of PSWE and sonographic grading system can predict postoperative EAD in LT recipients with high sensitivity. Abnormal results may suggest a need for liver biopsy preoperatively, thus avoiding unnecessary surgical preparation for liver procurement.

Key Points

• Combination of PSWE with new sonographic grading system is useful for preoperative evaluation of liver grafts from brain-dead donors.
• EAD is as a criterion for evaluating the diagnostic value of PSWE and sonographic grading system.
• Combination of PSWE and sonographic grading system can predict postoperative EAD in LT recipients with high sensitivity.
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Metadata
Title
Combination of liver graft sonographic grading and point shear wave elastography to reduce early allograft dysfunction after liver transplantation
Authors
Wen-yi Liu
Xuan-xuan Li
Xiao-yue Fu
Xiao-dong Wu
Xin Wang
Yuan Guo
Yun-jin Zang
Jian-hong Wang
Publication date
01-09-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 9/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-06842-5

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