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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2023

02-02-2023 | Liver Transplantation | Hepatobiliary Tumors

Where are We with Liver Transplant for Unresectable Colorectal Metastases? Its Early, but Some Initial Insights are Evident

Authors: S. Whitney Zingg, MD, Shimul A. Shah, MD, MHCM

Published in: Annals of Surgical Oncology | Issue 5/2023

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Excerpt

Liver transplantation for unresectable colorectal metastases (CRLM) has been increasing in recent years, with an almost tenfold increase in cases between 2017 and 2022. While historically CRLM has been a contraindication to liver transplant, modern chemotherapy has allowed a re-analysis of patients with unresectable CRLM. In 2012, the University of Oslo group demonstrated a significantly improved overall survival (OS) in patients who underwent liver transplantation when compared with chemotherapy alone for unresectable CRLM.1,2 As transplantation for these patients began to garner favor, the International Hepato-Pancreato-Biliary Association (IHPBA) published a consensus guideline in 2021 to provide a better framework for liver transplantation for unresectable CRLM.3 …
Literature
1.
Hagness M, Foss A, Line P, et al. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg. 2013;257(5):800–6.CrossRefPubMed
2.
Dueland S, Syversveen T, Solheim J, et al. Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases. Ann Surg. 2020;271(2):212–8.CrossRefPubMed
3.
Bonney GK, Chew CA, Lodge P, et al. Liver transplantation for non-resectable colorectal liver metastases: the international hepato-pancreato-biliary association consensus guidelines. Lancet Gastroenterol Hepatol. 2021;6(11):933–46.CrossRefPubMed
4.
Metadata
Title
Where are We with Liver Transplant for Unresectable Colorectal Metastases? Its Early, but Some Initial Insights are Evident
Authors
S. Whitney Zingg, MD
Shimul A. Shah, MD, MHCM
Publication date
02-02-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 5/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-13176-1

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