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Published in: Langenbeck's Archives of Surgery 1/2021

Open Access 01-02-2021 | Liver Transplantation | Systematic Reviews and Meta-analyses

Ex vivo machine perfusion: current applications and future directions in liver transplantation

Authors: Julian Michelotto, Joseph M. G. V. Gassner, Simon Moosburner, Vanessa Muth, Madhukar S. Patel, Markus Selzner, Johann Pratschke, Igor M. Sauer, Nathanael Raschzok

Published in: Langenbeck's Archives of Surgery | Issue 1/2021

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Abstract

Background

Liver transplantation is the only curative treatment option for end-stage liver disease; however, its use remains limited due to a shortage of suitable organs. In recent years, ex vivo liver machine perfusion has been introduced to liver transplantation, as a means to expand the donor organ pool.

Purpose

To present a systematic review of prospective clinical studies on ex vivo liver machine perfusion, in order to assess current applications and highlight future directions.

Methods

A systematic literature search of both PubMed and ISI web of science databases as well as the ClinicalTrials.​gov registry was performed.

Results

Twenty-one articles on prospective clinical trials on ex vivo liver machine perfusion were identified. Out of these, eight reported on hypothermic, eleven on normothermic, and two on sequential perfusion. These trials have demonstrated the safety and feasibility of ex vivo liver machine perfusion in both standard and expanded criteria donors. Currently, there are twelve studies enrolled in the clinicaltrials.​gov registry, and these focus on use of ex vivo perfusion in extended criteria donors and declined organs.

Conclusion

Ex vivo liver machine perfusion seems to be a suitable strategy to expand the donor pool for liver transplantation and holds promise as a platform for reconditioning diseased organs.
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Metadata
Title
Ex vivo machine perfusion: current applications and future directions in liver transplantation
Authors
Julian Michelotto
Joseph M. G. V. Gassner
Simon Moosburner
Vanessa Muth
Madhukar S. Patel
Markus Selzner
Johann Pratschke
Igor M. Sauer
Nathanael Raschzok
Publication date
01-02-2021
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 1/2021
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-020-02014-7

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