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Langenbeck's Archives of Surgery

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01-04-2004 | Original Article

Liver transplantation for hepatocellular carcinoma: a single European centre experience

Authors: Süleyman Yedibela, Thomas Förtsch, Werner Hohenberger, Thomas Meyer

Published in: Langenbeck's Archives of Surgery | Issue 2/2004

Abstract

Background

With respect to deficient donor grafts and the risk of tumour recurrence, indication for orthotopic liver transplantation (OLT) is still controversial. OLT offers the only chance for both the tumour and the underlying liver disease to be eliminated in patients with hepatocellular carcinoma (HCC) and cirrhosis. The aim of this study was to assess survival and related factors of recurrence.

Patients and methods

This retrospective study analyses data from 45 patients with HCC (UICC stage I/II, n=16; III, n=13; IV, n=12) treated with OLT between 1992 and 2002 in our centre. There were 39 primary tumours and two recurrent ones after previous surgical resection. Four perioperative deaths were excluded from analysis.

Results

Mean follow-up was 50.4 months. Five-year rates after OLT were 64% for overall survival, 78% for disease-specific survival, 73% for recurrence-free survival, and 22% for tumour recurrence. No tumour recurrence has been observed so far in patients with tumours of UICC stage I/II. None of the patient characteristics had a significant impact on survival, while tumour stage was significantly correlated with freedom from recurrence.

Conclusion

Our results demonstrate that the risk of recurrent HCC in liver transplanted patients is low for small and solitary tumours with no vascular invasion (UICC I/II). Even in advanced tumour stages (UICC III/IV), there is a real chance of cure or at least a survival benefit in selected patients.

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Title: Liver transplantation for hepatocellular carcinoma: a single European centre experience
Authors: Süleyman Yedibela
Thomas Förtsch
Werner Hohenberger
Thomas Meyer
Publication date: 01-04-2004
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 2/2004
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-003-0456-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liver transplantation for hepatocellular carcinoma: a single European centre experience

Abstract

Background

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusion

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Professor Dr. med. Dr. med. h. c. Walter Brendel 1922–1989