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Open Access 01-12-2024 | Liver Resection | Research

Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation—a single-center analysis

Authors: M. H. Fard-Aghaie, L. Stern, T. Ghadban, I. Apostolova, W. Lehnert, S. Klutmann, T. Hackert, J. R. Izbicki, J. Li, P. H. von Kroge, A. Heumann

Published in: Langenbeck's Archives of Surgery | Issue 1/2024

Abstract

Background

Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose, ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT (MSPECT) can be used. The aim of the current study was to evaluate the predictive value of MSPECT for PHLF in patients with non-colorectal liver tumors (NCRLT) compared to patients with colorectal liver metastasis (CRLM) undergoing extended liver resection.

Methods

We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT.

Results

Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m² vs. 1.51%/min/m²; p = 0.004).

Conclusion

Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.

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Title: Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation—a single-center analysis
Authors: M. H. Fard-Aghaie
L. Stern
T. Ghadban
I. Apostolova
W. Lehnert
S. Klutmann
T. Hackert
J. R. Izbicki
J. Li
P. H. von Kroge
A. Heumann
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Liver Resection
Liver Resection
Scintigraphy
Published in: Langenbeck's Archives of Surgery / Issue 1/2024
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-024-03280-5

At a glance: The STEP trials

Springer Medicine

Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation—a single-center analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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