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01-08-2021 | Liver Resection | Original Scientific Report

Correlation Between Portal Pressure and Indocyanine Green Retention Rate is Unaffected by the Cause of Cirrhosis: A Prospective Study

Authors: Kosuke Kobayashi, Emilie Uldry, Takashi Kokudo, Alessandra Cristaudi, Yoshikuni Kawaguchi, Chikara Shirata, Takamune Yamaguchi, Olivier Dormond, Rafael Duran, Kiyoshi Hasegawa, Nicolas Demartines, Nermin Halkic

Published in: World Journal of Surgery | Issue 8/2021

Abstract

Background

Accurate estimation of the hepatic functional reserve before liver resection is important to avoid post-hepatectomy liver failure (PHLF). The aim of the present study was to evaluate the association of indocyanine green retention test with portal pressure by the cause of cirrhosis (non-viral vs. viral) and assessed postoperative outcomes including incidence of PHLF in patients with viral and non-viral cirrhosis.

Methods

The cohort includes 50 consecutive patients with liver cirrhosis scheduled for liver resection for primary liver tumors at the Lausanne University Hospital between 2009 and 2018.

Results

There were 31 patients with non-viral liver cirrhosis (Non-virus group) and 19 with viral liver cirrhosis (virus group). The indocyanine green retention rate at 15 min (ICG-R15) (p = 0.276), Hepatic Venous Portal Gradient (HVPG; p = 0.301), and postoperative outcomes did not differ between the non-virus group and viral group. ICG-R15 and HVPG showed a significant linear correlation in all patients (Spearman’s rank correlation coefficient, ρ = 0.599, p < 0.001), the non-virus group (ρ = 0.555, p = 0.026), and the virus group (ρ = 0.534, p = 0.007). A receiver operating characteristic curve analysis showed that ICG-R15 was a predictor for presence of portal hypertension (PH; HVPG ≥ 12 mmHg) (area under the curve [AUC] = 0.780). The cut-off value of ICG-R15 for predicting the presence of PH was 16.0% with 72.3% of sensitivity and 79.0% of specificity.

Conclusions

The ICG-R15 level was associated with portal pressure in both patients with non-virus cirrhosis and patients with virus cirrhosis and predicts the incidence of PH with relatively good discriminatory ability.

Clinical trial number

https://clinicalTrials.gov(ID:NCT00827723)

Local ethics committee number

CER-VD 251.08

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Title: Correlation Between Portal Pressure and Indocyanine Green Retention Rate is Unaffected by the Cause of Cirrhosis: A Prospective Study
Authors: Kosuke Kobayashi
Emilie Uldry
Takashi Kokudo
Alessandra Cristaudi
Yoshikuni Kawaguchi
Chikara Shirata
Takamune Yamaguchi
Olivier Dormond
Rafael Duran
Kiyoshi Hasegawa
Nicolas Demartines
Nermin Halkic
Publication date: 01-08-2021
Publisher: Springer International Publishing
Keywords: Liver Resection
Liver Resection
Liver Cirrhosis
Portal Hypertension
Portal Hypertension
Published in: World Journal of Surgery / Issue 8/2021
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-021-06111-6

2024 ASCO Annual Meeting

Springer Medicine

Correlation Between Portal Pressure and Indocyanine Green Retention Rate is Unaffected by the Cause of Cirrhosis: A Prospective Study

Abstract

Background

Methods

Results

Conclusions

Clinical trial number

Local ethics committee number

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Clinical trial number

Local ethics committee number

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