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Japanese Journal of Radiology

26-04-2024 | Liver Cyst | Original Article

To identify important MRI features to differentiate hepatic mucinous cystic neoplasms from septated hepatic cysts based on random forest

Authors: Si-Yu Xiao, Jian-Xia Xu, Yi-Huan Shao, Ri-Sheng Yu

Published in: Japanese Journal of Radiology

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Abstract

Objective

To identify important MRI features to differentiate hepatic mucinous cystic neoplasms (MCN) from septated hepatic cysts (HC) using random forest and compared with logistic regression algorithm.

Methods

Pathologically diagnosed hepatic cysts and hepatic MCNs with pre-operative contrast-enhanced MRI in our hospital from 2010 to 2023 were collected and only septated lesions on enhanced MRI were enrolled. A total of 21 septated HC and 18 MCNs were included in this study. Eighteen MRI features were analyzed and top important features were identified based on random forest (RF) algorithm. The results were evaluated by the prediction performance of a RF model combining the important features and compared with the performance of the logistic regression (LR) algorithm. Finally, for each identified feature, diagnostic probability, sensitivity, and specificity were calculated and compared.

Results

Four variables, i.e., the septation arising from wall without indentation, multiseptate, intracapsular cyst sign, and solitary lesion were extracted as top important features with significance for MCNs by the random forest algorithm. The RF model using these variables had an AUC of 0.982 (0.95CI, 0.950–1.000), compared with the LR model based on two identified features with AUC of 0.931 (0.95CI, 0.846–1.000), p = 0.202. Among the four important features, multiseptate had the highest specificity (95.2%) and good sensitivity (72.2%, lower than the septation from wall without indentation, 94.4%) to diagnose MCNs.

Conclusion

Four out of 18 MRI features were extracted as reliably important factors to differ hepatic MCNs from septated HC. The combination of these four features in a RF model could achieve satisfactory diagnostic efficacy.
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Metadata
Title
To identify important MRI features to differentiate hepatic mucinous cystic neoplasms from septated hepatic cysts based on random forest
Authors
Si-Yu Xiao
Jian-Xia Xu
Yi-Huan Shao
Ri-Sheng Yu
Publication date
26-04-2024
Publisher
Springer Nature Singapore
Keyword
Liver Cyst
Published in
Japanese Journal of Radiology
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-024-01562-y