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Published in: Italian Journal of Pediatrics 1/2017

Open Access 01-12-2017 | Case report

Liver chemistry in new-onset Henoch-Schönlein syndrome

Authors: Giulia Rosti, Gregorio P. Milani, Emanuela A. Laicini, Emilio F. Fossali, Mario G. Bianchetti

Published in: Italian Journal of Pediatrics | Issue 1/2017

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Abstract

Background

Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement in this syndrome. This study investigated liver chemistry and creatine kinase in Henoch-Schönlein children.

Case presentation

Alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, lactate dehydrogenase, total bilirubin, prothrombin time and creatine kinase were assessed in 75 consecutive pediatric patients (41 boys and 34 girls aged from 2.9 to 17 years) with new-onset Henoch-Schönlein syndrome. Mildly altered values were found in 7 (9%) patients (5 boys and 2 girls aged from 3.3 to 17 years). In the mentioned cases, all tests returned to normal at a 2–4-week follow-up.

Conclusions

This preliminary study points out that altered and self-remitting liver parameters occur in approximately 10% of children with Henoch-Schönlein syndrome.
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Metadata
Title
Liver chemistry in new-onset Henoch-Schönlein syndrome
Authors
Giulia Rosti
Gregorio P. Milani
Emanuela A. Laicini
Emilio F. Fossali
Mario G. Bianchetti
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2017
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-017-0405-5

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