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Langenbeck's Archives of Surgery

Published in:

01-08-2019 | Review Article

Liquid biopsy for the detection and management of surgically resectable tumors

Authors: Barbara Aldana Blanco, Christopher L. Wolfgang

Published in: Langenbeck's Archives of Surgery | Issue 5/2019

Abstract

Background

Traditional biopsies have numerous limitations in the developing era of precision medicine, with cancer treatment that relies on biomarkers to guide therapy. Tumor heterogeneity raises the potential for sampling error with the use of traditional biopsy of the primary tumor. Moreover, tumors continuously evolve as new clones arise in the natural course of the disease and under the pressure of treatment. Since traditional biopsy is invasive, it is neither feasible nor practical to perform serial biopsies to guide treatment in real time.

Purpose

The current manuscript will review the most commonly used types of liquid biopsy and how these apply to surgical patients in terms of diagnosis, prediction of outcome, and guiding therapy.

Conclusions

Liquid biopsy has the potential to overcome many of the limitations of traditional biopsy as a highly tailored, minimally invasive, and cost-effective method to screen and monitor response to treatment. However, many challenges still need to be overcome before liquid biopsy becomes a reliable and widely available option.

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Title: Liquid biopsy for the detection and management of surgically resectable tumors
Authors: Barbara Aldana Blanco
Christopher L. Wolfgang
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 5/2019
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-019-01788-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liquid biopsy for the detection and management of surgically resectable tumors

Abstract

Background

Purpose

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Purpose

Conclusions

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