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Molecular Cancer
Published in: Molecular Cancer 1/2018

Open Access 01-12-2018 | Review

Liquid biomarkers in melanoma: detection and discovery

Authors: Su Yin Lim, Jenny H. Lee, Russell J. Diefenbach, Richard F. Kefford, Helen Rizos

Published in: Molecular Cancer | Issue 1/2018

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Abstract

A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumor and immune cells are emerging as convenient and accurate liquid biomarkers of cancer. Circulating cancer biomarkers provide invaluable information on cancer detection and diagnosis, prognosticate patient outcomes, and predict treatment response. In this era of effective molecular targeted treatments and immunotherapies, there is now an urgent need to implement use of these circulating biomarkers in the clinic to facilitate personalized therapy. In this review, we present recent findings in circulating melanoma biomarkers, examine the challenges and promise of evolving technologies used for liquid biomarker discovery, and discuss future directions and perspectives in melanoma biomarker research.
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Metadata
Title
Liquid biomarkers in melanoma: detection and discovery
Authors
Su Yin Lim
Jenny H. Lee
Russell J. Diefenbach
Richard F. Kefford
Helen Rizos
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2018
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-018-0757-5

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