Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
MUSCULOSKELETAL SURGERY
Published in: MUSCULOSKELETAL SURGERY 3/2014

01-12-2014 | Review

Liposarcoma: a soft tissue tumor with many presentations

Authors: H. J. Mankin, K. P. Mankin, D. C. Harmon

Published in: MUSCULOSKELETAL SURGERY | Issue 3/2014

Login to get access

Abstract

Liposarcoma is an uncommon connective tissue tumor arising from lipoblast cells. The lesion is located in body soft parts and rarely arises from the bones. The tumors are variable in presentation ranging from benign well-differentiated tumors to myxoid and round cell-dedifferentiated and pleomorphic forms which can present with metastases. The lesions are most often treated by surgical resection. Chemotherapy and radiation may be added to the treatment of the more malignant variants with some success.
Literature
1.
2.
3.
Austin RM, Dupre WB (1986) Liposarcoma of the breast: a clinicopathologic study of 20 cases. Hum Pathol 17:906–913PubMedCrossRef
4.
Binh MB, Sastra-Gurau X, Guillou L (2005) MDM2 and CDK4 immunostaining are useful adjuncts in diagnosis of well-differentiated and dedifferentiated liposarcoma subtypes. Am J Surg Pathol 29:1340–1347PubMedCrossRef
5.
Cai Y-C, McMenamin ME, Rose G et al (2001) Primary liposarcoma of the orbit. Ann Diagn Pathol 5:255–266PubMedCrossRef
6.
Chang HR, Hajdu SI, Collin C et al (1989) The prognostic value of histologic subtypes in primary extremity liposarcoma. Cancer 64:1514–1520PubMedCrossRef
7.
Cheng EY, Springfield DS, Mankin HJ (1995) Frequent incidence of extrapulmonary sites of initial metastasis in patients with liposarcoma. Cancer 75:1120–1127PubMedCrossRef
8.
Delamater J (1859) Mammoth tumor. Cleve Med Gaz 1:31
9.
Delannes M, Thomas L, Martel P et al (2000) Low dose rate inter-operative brachytherapy combined with external beam irradiation in the conservative treatment of soft tissue sarcoma. Int J Radiat Oncol Biol Phys 47:165–169PubMedCrossRef
10.
Eilber FC, Eilber FR, Singer S (2004) The impact of chemotherapy on the survival of patients with high grade primary extremity liposarcoma. Ann Surg 240:686–697PubMedCentralPubMed
11.
Enterline HT, Culberson JD, Rochlin DB, Brady LW (1960) Liposarcoma; a clinical and pathologic study of 53 cases. Cancer 13:932–950PubMedCrossRef
12.
Enzinger FM, Weiss SW (1995) Liposarcoma. in Weiss’s Soft Tissue Tumor. 3rd Edition, Mosby, 686–697
13.
Enzinger FM, Winslow DJ (1962) Liposarcoma; a study of 103 cases. Arch Path 335:367–388CrossRef
14.
Estourgie SH, Nielsen GP, Ott MJ (2002) Metastatic patterns of extremity myxoid liposarcoma and their outcome. J Surg Oncol 80(2):89–93PubMedCrossRef
15.
Evans HL (1979) Liposarcoma a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 3:507–523PubMedCrossRef
16.
Ewing J (1935) Fascial sarcoma and intermuscular myxoliposarcoma. Arch Surg 31:507–520CrossRef
17.
Fiore M, Grosso F, LoVullo S et al (2007) Myxoid/round cell and pleomorphic liposarcoma: prognostic factors and survival in a series of patients treated at a single institution. Cancer 109:2522–2531PubMedCrossRef
18.
Fletcher CDM, Unni KK (eds) (2002) Pathologic and genetics: tumors of soft tissue and bone World Health Organization Classification of Tumors. IARC Press, Lyon, pp 35–46
19.
Gagari E, Kabani S, Gallagher GT (2000) Intraoral liposarcoma case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 89:66–72CrossRef
20.
Grosso F, Sanfilippo R, Virdis E et al (2009) Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series. Ann Oncol 20:1439–1444PubMedCrossRef
21.
22.
Henricks WH, Chu YC, Goldblum JR, Weiss SW (1997) Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of differentiation. Am J Surg Pathol 21:271–281PubMedCrossRef
23.
Hogg ME, Wayne JD (2012) Atypical lipomatous tumor/well differentiated liposarcoma. What is it? Surg Clin North Am 21:333–340CrossRef
24.
Jaffe RH (1926) Recurrent lipomatous tumors of the groin: liposarcoma and lipoma psuedomixomatodes. Arch Pathol 1:381–387
25.
26.
Khurana JS, Rosenthal DI, Rosenberg AE, Mankin HJ (1989) Skeletal metastases in liposarcoma detectable only by magnetic resonance imaging. Clin Orthop Rel Res 243:204–207
27.
Kilpatrick SE, Doyon J, Choong PFM et al (1996) The clinicopathologic spectrum of myxoid and round cell liposarcoma: a study of 95 cases. Cancer 77:1450–1458PubMedCrossRef
28.
Kindblom LG, Angervaal L, Fassina AS (1982) Atypical lipoma. Act Pathol Microbiol Immunol Scand 90A:27–36
29.
Knight JC, Renwick PH, Cin PD et al (1995) Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 55:24–27PubMed
30.
Leach FS, Tokino T, Meltzer P et al (1993) p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 15(10 Suppl):2231–2234
31.
32.
Lietman SA, Varsoum WK, Goldblum JR et al (2007) A 20 year retrospective review of surgically treated liposarcomas at the Cleveland Clinic. Orthopedics 30:9–18
33.
Linehan DC, Lewis JJ, Leung D, Brennan MF (2000) Influence of biologic factor and anatomic site in completely resected liposarcoma. J Clin Oncol 18:1637–1643PubMed
34.
Loubignac F, Bourtoul C, Chapel F (2009) Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. World J Surg Oncol 7:42–49PubMedCentralPubMedCrossRef
35.
Maheshwari GK, Maheshwari GK, Baboo HA, Patel MH et al (2002) Liposarcoma of the floor of the mouth: a case report. Turk J Cancer 32:69–74
36.
Mandahl N, Hoaglund M, Mertens F et al (1994) Cytogenetic aberrations in 188 benign an borderline adipose tissue tumors. Genes Chromosom Cancer 9:207–215PubMedCrossRef
37.
Mankin HJ, Hornicek FJ (2005) Diagnosis, classification and management of soft tissue sarcomas. Moffitt Cancer Control 12:8–21
38.
Moreau-Zabotto L, Thomas L, Bui BN et al (2004) Management of soft tissue sarcomas (STS) in first isolated local recurrence: a retrospective study of 83 cases. Radiother Oncol 73:313–319CrossRef
39.
40.
Nascimento AG (2001) Dedifferentiated liposarcoma. Semin Diagn Pathol 18:263–266PubMed
41.
Nielsen VT, Knudsen N, Holm E (1986) Liposarcoma of the thyroid gland. Tumori 72:499–502PubMed
42.
Nori D, Shupak K, Shiu MF, Brennan M (1991) Role of brachytherapy in recurrent extremity sarcoma in patient treated with prior surgery and irradiation. Int J Radiat Oncol Biol Phys 20:122901233CrossRef
43.
Oliveira AM, Nascimento AG (2001) Pleomorphic liposarcoma. Semin Diagn Pathol 18:274–285PubMed
44.
Pack GT, Pierson JC: Liposarcoma: a study of 105 cases. Surgery: 687–712, 1954
45.
Peterstone DB, Janjan NA, Feig BW et al (1999) Re-resection with brachytherapy for locally recurrent soft tissue sarcoma arising a previously radiated field. Cancer J Sci Am 5:18–19
46.
Peterson JJ, Kransdorf MJ, Bancroft LW, O’Connor MI (2003) Malignant fatty tumors: classification, clinical course, imaging appearance and treatment. Skelet Radiol 32:493–503CrossRef
47.
Prestwich RJ, Taylor RE, Grimer R (2005) Metastatic myxoid liposarcoma: aggressive multimodality management. Clin Oncol 17:130–134CrossRef
48.
Rabbits T, Forster A, Larson R, Nathan P (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gen FUS by translocation t(12;16). Nat Genet 4:175–180CrossRef
49.
Reitan JB, Kaalhsu O, Brennhovd IO et al (1985) Prognostic factors in liposarcoma. Cancer 55:2482–2490PubMedCrossRef
50.
Reszel PA, Soule EH, Coventry MB (1966) Liposarcoma of the extremities and limb girdles: a study of two-hundred-twenty-two cases. J Bone Joint Surg 48A:229–244
51.
52.
Roque P, Mankin HJ, Hornicek FJ, Nyame T (2007) Extremity liposarcoma: prognostic indirs. Therapy 4:299–305CrossRef
53.
Rosai J, Akerman M, Dal Cin P et al (1996) Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group). Am J Surg Pathol 20:1182–1189PubMedCrossRef
54.
55.
Sakamoto A, Oda HY, Adachi T et al (2002) Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma. Arch Pathol Lab Med 126:1071–1078PubMed
56.
Seids JV, McGinnis RS (1927) Malignant tumors of fatty tissues. Surg Gynec Obstet 44:232–243
57.
58.
Skubitz KM, Cheng EY, Clohisy DR, Skubitz AP (2005) Differentiated gene expression in liposarcoma, lipoma and adipose tissue. Clin Invest 23:105–118
59.
Singer S, Demetri GD, Baldini EH, Fletcher CD (2000) Management of soft-tissue sarcomas: an overview and update. Lancet Oncol 1:75–85PubMedCrossRef
60.
Spillane AJ, Fisher C, Thomas JM (1999) Myxoid Liposarcoma: the frequency and the natural +history of non-pulmonary soft tissue metastases. Ann Surg Oncol 6:389–394PubMedCrossRef
61.
62.
Stewart MG, Schwartz MR, Alford BR (1994) Atypical and malignant lipomatous lesions of the head and neck. Arch Otalaryngol Head Neck Surg 120:1151–1155CrossRef
63.
64.
Stout AP, Lattes R (1967) Liposarcoma in tumors of the soft tissues. AFIP, Washington, DC, pp 116–126
65.
Suit JD, Mankin HJ, Schiller AL et al (1985) Results of treatment of sarcoma of soft tissue by radiation and surgery at the Massachusetts General Hospital. Cancer Treat Symp 3:43–47
66.
Takahira T, Oda Y, Tamiya S et al (2005) Alterations of the RB1gene in dedifferentiated liposarcoma. Mod Pathol 18:1461–1470PubMedCrossRef
67.
Toguchida J, Yamaguchi T, Ritchie B et al (1992) Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. Cancer Res 15:6194–6199
68.
Virchow R (1857) Einall von bosartigen, zum theil in der form des neurons auftretenden fettgeschwullsen. Virchow Arch Pathol Anat Histopathol 11:281–288CrossRef
69.
Virkus WW, Mollabashy A, Reith JD et al (2002) Preoperative radiotherapy in the treatment of soft tissue sarcomas. Clin Orthop 397:177–189PubMedCrossRef
70.
Weiss SW, Goldblum JR (2008) Enzinger and Weiss’s soft tissue tumors, 5th edn. Mosby, St. Louis (MO), pp 477–516
71.
Willett CG, Schiller AL, Suit HD, Mankin HJ, Rosenberg AE (1987) The histologic response of soft tissue sarcoma to radiation therapy. Cancer 60:1500–1504PubMedCrossRef
72.
Wong CK, Edwards AT, Rees BI (1997) Liposarcoma: a review of current diagnosis and management. Br J Hosp Med 58:589–591PubMed
73.
Yang JC, Chang AE, Barker AR et al (1998) A randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16:197–203PubMed
74.
Zagers GK, Goswitz MS, Pollack A (1996) Liposarcoma: outcome and prognostic factors following conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys 36:311–319CrossRef
75.
Zeytoonjian T, Mankin HJ, Gebhardt MC, Hornicek FJ (2004) Distal lower extremity sarcomas:frequency of occurrence and patient survival rate. Foot Ankle Internat 25:325–330
Metadata
Title
Liposarcoma: a soft tissue tumor with many presentations
Authors
H. J. Mankin
K. P. Mankin
D. C. Harmon
Publication date
01-12-2014
Publisher
Springer Milan
Published in
MUSCULOSKELETAL SURGERY / Issue 3/2014
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI
https://doi.org/10.1007/s12306-014-0332-1

Other articles of this Issue 3/2014

MUSCULOSKELETAL SURGERY 3/2014 Go to the issue

Original Article

Cemented or cementless THA in patients over 80 years with fracture neck of femur: a prospective comparative trial

Original Article

Efficacy, usability and tolerability of a dynamic elbow orthosis after collateral ligament reconstruction: a prospective randomized study

Original Article

Adult proximal humerus locking plate for fixation of paediatric subtrochanteric fractures

Original Article

The outcome of paediatric LCP hip plate use in children with and without neuromuscular disease

Case Report

Congenital bowing of the tibia due to infantile lipofibromatosis corrected with a Taylor Spatial Frame

Case Report

Is it ever safe to discharge a chondrosarcoma of pelvis? Report of a local recurrence after 10 years