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Inflammation
Published in: Inflammation 6/2011

01-12-2011

Lipopolysaccharide-Mediated Induction of Calprotectin in the Submandibular and Parotid Glands of Mice

Authors: Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata, Kazuo Hosoi

Published in: Inflammation | Issue 6/2011

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Abstract

S100A8 and S100A9 constitute a heterodimeric protein, calprotectin. The mRNAs of S100A8 and S100A9, being expressed at minimal levels in the submandibular and parotid glands (SMG and PG, respectively) of C3H/HeN mice, were induced strongly and transiently by lipopolysaccharide (LPS). Among the mRNAs of members of the S100 protein family examined, those of S100A8 and S100A9 were specifically induced by LPS in the salivary glands. The induction was assumed to be mediated via toll-like receptor 4 (TLR4), since their elevation was limited in C3H/HeJ mice, a TLR4-mutant strain. These proteins became expressed in the granular convoluted tubular cells and striated duct cells in the SMG, and in both acinar and duct cells in the PG (all in the cytoplasm). The salivary calprotectin level was not increased by LPS treatment, implying that elevated calprotectin was not secreted into the saliva and that they may function in microcellular environment of the salivary gland.
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Metadata
Title
Lipopolysaccharide-Mediated Induction of Calprotectin in the Submandibular and Parotid Glands of Mice
Authors
Purevjav Javkhlan
Yuka Hiroshima
Ahmad Azlina
Takahiro Hasegawa
Chenjuan Yao
Tetsuya Akamatsu
Jun-ichi Kido
Toshihiko Nagata
Kazuo Hosoi
Publication date
01-12-2011
Publisher
Springer US
Published in
Inflammation / Issue 6/2011
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-010-9277-1

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