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Pediatric Nephrology
Published in: Pediatric Nephrology 7/2003

01-07-2003 | Brief Report

Lip hypertrophy secondary to cyclosporin treatment

Authors: Janette Christine Cansick, Sally-Anne Hulton

Published in: Pediatric Nephrology | Issue 7/2003

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Abstract

Gingival hypertrophy is a well-documented side effect of cyclosporin therapy, but severe lip enlargement is less frequently recognised. This can lead to poor body image, low self-esteem and non-compliance, especially in the older childhood and adolescent age groups. We describe two paediatric renal transplant recipients who had marked lip hypertrophy as a consequence of cyclosporin (Neoral) treatment. On changing the immunosuppression to tacrolimus (Prograf), this resolved. We recommend that a change in immunosuppressant therapy be considered in children with significant changes to facial appearance.
Literature
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Seymour RA, Thomason JM, Nolan A (1997) Oral lesions in organ transplant patients. J Oral Pathol Med 26:297–304PubMed
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Regev E, Zeltser R, Lustmann J (1992) Lip carcinoma in renal allograft recipient with long-term immunosuppressive therapy. Oral Surg Oral Med Oral Pathol 73: 412–414PubMed
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Ellis D, Shapiro R, Jordan ML, Scantlebury VP, Gilboa N, Hopp L, Weichler N, Tzakis AG, Simmons RL (1994) Comparison of FK-506 and cyclosporine regimens in pediatric renal transplantation. Pediatr Nephrol 8:193–200PubMed
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Armitage JM, Fricker FJ, Nido P del, Starzl TE, Hardesty RL, Griffith BP (1993) A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FL 506 immunosuppression. J Thorac Cardiovasc Surg 105:464–473PubMed
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Shield CF, McGrath MM, Goss TF (1997) Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. Transplantation 64:1738–1743PubMed
Metadata
Title
Lip hypertrophy secondary to cyclosporin treatment
Authors
Janette Christine Cansick
Sally-Anne Hulton
Publication date
01-07-2003
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 7/2003
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1144-y

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