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Open Access 01-08-2007 | Original Article

Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux

Authors: Albertien M. van Eerde, Bobby P. C. Koeleman, Jiddeke M. van de Kamp, Tom P. V. M. de Jong, Cisca Wijmenga, Jacques C. Giltay

Published in: Pediatric Nephrology | Issue 8/2007

Abstract

Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed a linkage study in four large, Dutch, multi-generational families with multiple affected individuals. We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLIT2, SPRY1, PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13 and 20p13 loci from linkage to VUR. Our results provide further evidence that there appears to be genetic heterogeneity in VUR.

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Title: Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
Authors: Albertien M. van Eerde
Bobby P. C. Koeleman
Jiddeke M. van de Kamp
Tom P. V. M. de Jong
Cisca Wijmenga
Jacques C. Giltay
Publication date: 01-08-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0492-4

Keynote webinar | Spotlight on medication adherence

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Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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