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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2001

Open Access 01-12-2001 | Research article

Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study

Authors: Susan L Neuhausen, Michael Feolo, James Farnham, Linda Book, John J Zone

Published in: BMC Medical Genetics | Issue 1/2001

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Abstract

Background

Celiac disease has a strong genetic association with HLA. However, this association only explains approximately half of the sibling risk for celiac disease. Therefore, other genes must be involved in susceptibility to celiac disease. We tested for linkage to genes or loci that could play a role in pathogenesis of celiac disease.

Methods

DNA samples, from members of 62 families with a minimum of two cases of celiac disease, were genotyped at HLA and at 13 candidate gene regions, including CD4, CTLA4, four T-cell receptor regions, and 7 insulin-dependent diabetes regions. Two-point and multipoint heterogeneity LOD (HLOD) scores were examined.

Results

The highest two-point and multipoint HLOD scores were obtained in the HLA region, with a two-point HLOD of 3.1 and a multipoint HLOD of 5.0. For the candidate genes, we found no evidence for linkage.

Conclusions

Our significant evidence of linkage to HLA replicates the known linkage and association of HLA with CD. In our families, likely candidate genes did not explain the susceptibility to celiac disease.
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Metadata
Title
Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study
Authors
Susan L Neuhausen
Michael Feolo
James Farnham
Linda Book
John J Zone
Publication date
01-12-2001
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2001
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-2-12

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