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American Journal of Clinical Dermatology

01-02-2010 | Review Article

A Current Review of Juvenile Pemphigus Vulgaris

Analysis of Data on Clinical Outcomes

Authors: Adam Asarch, Hakan M. Gürcan, Dr A. Razzaque Ahmed

Published in: American Journal of Clinical Dermatology | Issue 1/2010

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Abstract

Forty-seven cases of juvenile pemphigus vulgaris have been reported in the English literature. Histology of lesional skin and direct immunofluorescence of perilesional skin are both necessary for a complete diagnosis. The autoimmune bullous condition can affect the skin and mucous membranes individually, but typically affects both concurrently. Disease characteristics in juvenile patients are similar to those in adults; however, a disruption of biologic and social development is of particular concern during adolescence. Although systemic corticosteroids have been used to successfully treat the disease in most cases, long-term use is often necessary for adequate control. Adverse effects from therapy can have devastating effects during this critical period of hormonal changes, physical and mental growth, and social and cultural development that occurs during adolescence. Newer therapies must be designed to adequately treat juvenile patients while also limiting serious adverse effects
Literature
1.
Bystryn JC, Rudolph JL. Pemphigus. Lancet 2005 Jul 2-8; 366 (9479): 61–73PubMed
2.
Ahmed AR, Salm M. Juvenile pemphigus. J Am Acad Dermatol 1983 Jun; 8 (6): 799–807PubMed
3.
Sillevis Smitt JH. Pemphigus vulgaris in childhood: clinical features, treatment, and prognosis. Pediatr Dermatol 1985 Mar; 2 (3): 185–90PubMed
4.
Elias PM, Jarratt M, Zalitis IE, et al. Childhood pemphigus vulgaris. N Engl J Med 1972 Oct 12; 287 (15): 758–60PubMed
5.
Menter MA, Bell AA, Wells RS. Pemphigus vulgaris in a boy aged thirteen. Guys Hosp Rep 1973; 122 (1-2): 123–7PubMed
6.
Wrancz AE. Combined treatment with steroids and imuran of pemphigus vulgaris in a 15-year-old girl [in Polish]. Przegl Dermatol 1975; 62: 551–3
7.
Harrington I, Sneddon IB, Walker AE. Pemphigus vulgaris in a 15-year-old girl. Acta Derm Venereol 1978; 58 (3): 277–9PubMed
8.
Sodaify M, Vollum DI. Pemphigus vulgaris in adolescence. Clin Exp Dermatol 1979 Jun; 4 (2): 205–7PubMed
9.
Laskaris G, Sklavounou A, Bovopoulou O. Juvenile pemphigus vulgaris. Oral Surg Oral Med Oral Pathol 1981 Apr; 51 (4): 415–20PubMed
10.
Hempstead RW, Marks Jr JG. Pediatric pemphigus vulgaris: treatment with topical adrenal steroids. Arch Dermatol 1984 Jul; 120 (7): 962–3PubMed
11.
Lynde CW, Ongley RC, Rigg JM. Juvenile pemphigus vulgaris. Arch Dermatol 1984 Aug; 120 (8): 1098–9PubMed
12.
Jacyk WK, Dyer RB. Juvenile pemphigus vulgaris: a case report. S Afr Med J 1987 Mar 7; 71 (5): 325PubMed
13.
David M, Zaidenbaum M, Sandbank M. Juvenile pemphigus vulgaris: a 4- to 19-year follow-up of 4 patients. Dermatologica 1988; 177 (3): 165–9PubMed
14.
Graff-Lonnevig V, Kaaman T. Juvenile pemphigus vulgaris. Acta Paediatr Scand 1991 Feb; 80 (2): 262–5PubMed
15.
Kanwar AJ, Kaur S. Pemphigus in children. Int J Dermatol 1991 May; 30 (5): 343–6PubMed
16.
Gorsky M, Raviv M, Raviv E. Pemphigus vulgaris in adolescence: a case presentation and review of the literature. Oral Surg Oral Med Oral Pathol 1994 Jun; 77 (6): 620–2PubMed
17.
Kanwar AJ, Dhar S, Kaur S. Further experience with pemphigus in children. Pediatr Dermatol 1994 Jun; 11 (2): 107–11PubMed
18.
Wananukul S, Pongprasit P. Childhood pemphigus. Int J Dermatol 1999 Jan; 38 (1): 29–35PubMed
19.
Schmidt E, Herzog S, Brocker EB, et al. Long-standing remission of recalcitrant juvenile pemphigus vulgaris after adjuvant therapy with rituximab. Br J Dermatol 2005 Aug; 153 (2): 449–51PubMed
20.
Yazganoglu KD, Baykal C, Kucukoglu R. Childhood pemphigus vulgaris: five cases in 16 years. J Dermatol 2006 Dec; 33 (12): 846–9PubMed
21.
Mamelak AJ, Eid MP, Cohen BA, et al. Rituximab therapy in severe juvenile pemphigus vulgaris. Cutis 2007 Oct; 80 (4): 335–40PubMed
22.
Asarch A, Ahmed AR. Treatment of juvenile pemphigus vulgaris with intravenous immunoglobulin therapy. Pediatr Dermatol 2009 Mar-Apr; 26 (2): 197–202PubMed
23.
Ahmed AR, Dahl MV. Consensus statement on the use of intravenous immunoglobulin therapy in the treatment of autoimmune mucocutaneous blistering diseases. Arch Dermatol 2003 Aug; 139 (8): 1051–9PubMed
24.
Chams-Davatchi C, Valikhani M, Daneshpazhooh M, et al. Pemphigus: analysis of 1209 cases. Int J Dermatol 2005 Jun; 44 (6): 470–6PubMed
25.
Esmaili N, Chams-Davatchi C, Valikhani M, et al. Pemphigus vulgaris in Iran: a clinical study of 140 cases. Int J Dermatol 2007 Nov; 46 (11): 1166–70PubMed
26.
Ljubojevic S, Lipozencic J, Brenner S, et al. Pemphigus vulgaris: a review of treatment over a 19-year period. J Eur Acad Dermatol Venereol 2002 Nov; 16 (6): 599–603PubMed
27.
Lever WF, White H. Treatment of pemphigus with corticosteroids: results obtained in 46 patients over a period of 11 years. Arch Dermatol 1963 Jan; 87: 12–26PubMed
28.
Robinson JC, Lozada-Nur F, Frieden I. Oral pemphigus vulgaris: a review of the literature and a report on themanagement of 12 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Oct; 84 (4): 349–55PubMed
29.
Bystryn JC, Steinman NM. The adjuvant therapy of pemphigus: an update. Arch Dermatol 1996 Feb; 132 (2): 203-2PubMed
30.
Diab M, Bechtel M, Coloe J, et al. Treatment of refractory pemphigus erythematosus with rituximab. Int J Dermatol 2008 Dec; 47 (12): 1317–8PubMed
31.
Daoud YJ, Amin KG. Comparison of cost of immune globulin intravenous therapy to conventional immunosuppressive therapy in treating patients with autoimmune mucocutaneous blistering diseases. Int Immunopharmacol 2006 Apr; 6 (4): 600–6PubMed
32.
Yokota S, Mori M, Imagawa T, et al. Proposal for juvenile idiopathic arthritis guidance on diagnosis and treatment for primary care pediatricians and nonpediatric rheumatologists (2007). Mod Rheumatol 2007; 17 (5): 353–63PubMed
33.
Compeyrot-Lacassagne S, Feldman BM. Inflammatory myopathies in children. Rheum Dis Clin North Am 2007 Aug; 33 (3): 525–53, viiPubMed
34.
Fisler RE, Liang MG, Fuhlbrigge RC, et al. Aggressive management of juvenile dermatomyositis results in improved outcome and decreased incidence of calcinosis. J Am Acad Dermatol 2002 Oct; 47 (4): 505–11PubMed
35.
Macdermott EJ, Adams A, Lehman TJ. Systemic lupus erythematosus in children: current and emerging therapies. Lupus 2007; 16 (8): 677–83PubMed
36.
Brunner HI, Gladman DD, Ibanez D, et al. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 2008 Feb; 58 (2): 556–62PubMed
37.
Kone-Paut I, Piram M, Guillaume S, et al. Lupus in adolescence. Lupus 2007; 16 (8): 606–12PubMed
38.
Mintzer IJ, Rubin Z. Pemphigus vulgaris in a thirteen-year-old girl. NY State J Med 1955 Jul 1; 55 (13): 1903–7
39.
Jordon RE, Ihrig JJ, Perry HO. Childhood pemphigus vulgaris: report of a case. Arch Dermatol 1969 Feb; 99 (2): 176–9PubMed
40.
Rosenberg FR, Sanders S, Nelson CT. Pemphigus: a 20-year review of 107 patients treated with corticosteroids. Arch Dermatol 1976 Jul; 112 (7): 962–70PubMed
41.
Bjarnason B, Flosadottir E. Childhood, neonatal, and stillborn pemphigus vulgaris. Int J Dermatol 1999 Sep; 38 (9): 680–8PubMed
42.
Harman KE, Albert S, Black MM. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 2003 Nov; 149 (5): 926–37PubMed
Metadata
Title
A Current Review of Juvenile Pemphigus Vulgaris
Analysis of Data on Clinical Outcomes
Authors
Adam Asarch
Hakan M. Gürcan
Dr A. Razzaque Ahmed
Publication date
01-02-2010
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 1/2010
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.2165/11310380-000000000-00000