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American Journal of Clinical Dermatology

Published in:

01-01-2003 | Review Article

Adverse Cutaneous Reactions to Mood Stabilizers

Authors: Dr Julia K. Warnock, David W. Morris

Published in: American Journal of Clinical Dermatology | Issue 1/2003

Abstract

Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs).

An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of a severe and life-threatening ACDR, such as a hypersensitivity reaction, Stevens- Johnson syndrome, or toxic epidermal necrolysis. The combination of mood-stabilizing agents may increase the risk of such reactions. The mood-stabilizing agents addressed in this article are carbamazepine, lithium carbonate, valproic acid, topiramate, lamotrigine, gabapentin, and oxcarbazepine.

Prior to the initiation of a mood stabilizer, the potential benefits, risks, and adverse effects should be communicated to the patient. If possible, slow dose escalation should be attempted by the physician. Patients should also be advised to seek medical attention if they suspect a drug-induced skin reaction. If the physician suspects a severe ACDR, the offending agent should be removed immediately.

Use of tradenames is for product identification only and does not imply endorsement.

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Title: Adverse Cutaneous Reactions to Mood Stabilizers
Authors: Dr Julia K. Warnock
David W. Morris
Publication date: 01-01-2003
Publisher: Springer International Publishing
Published in: American Journal of Clinical Dermatology / Issue 1/2003
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.2165/00128071-200304010-00003

At a glance: The STEP trials

Springer Medicine

Adverse Cutaneous Reactions to Mood Stabilizers

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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