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CNS Drugs
Published in: CNS Drugs 1/2008

01-01-2008 | Commentary

Quetiapine

Dose-Response Relationship in Schizophrenia

Author: Dr Leslie Citrome

Published in: CNS Drugs | Issue 1/2008

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Excerpt

The review by Sparshatt et al.[1] makes the strong conclusion that the standard dosage range for quetiapine (150–750 mg/day, with an optimal dosage of 300–400 mg/day) is appropriate for clinical use. However, this is not consistent with clinical practice where prescribers are using dosages that exceed product label recommendations.[2] This illustrates the gap between clinical practice and the state of the evidence. …
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Citrome L, Jaffe A, Levine J, et al. Dosing of quetiapine in schizophrenia: how clinical practice differs from registration studies. J Clin Psychiatry 2005; 66(12): 1512–6PubMedCrossRef
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Citrome L, Jaffe A, Levine J. Dosing of second-generation antipsychotic medication in a state hospital system. J Clin Psychopharmacol 2005; 25(4): 388–91PubMedCrossRef
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Citrome L, Jaffe A, Levine J, et al. Use of mood stabilizers among patients with schizophrenia, 1994–2001. Psychiatr Serv 2002; 53(10): 1212PubMedCrossRef
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Stroup TS, Lieberman JA, McEvoy JP, et al. Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study. Am J Psychiatry 2007; 164(3): 415–27PubMedCrossRef
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Pae CU, Kim JJ, Lee CU, et al. Rapid versus conventional initiation of quetiapine in the treatment of schizophrenia: a randomized, parallel-group trial. J Clin Psychiatry 2007; 68(3): 399–405PubMedCrossRef
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Metadata
Title
Quetiapine
Dose-Response Relationship in Schizophrenia
Author
Dr Leslie Citrome
Publication date
01-01-2008
Publisher
Springer International Publishing
Published in
CNS Drugs / Issue 1/2008
Print ISSN: 1172-7047
Electronic ISSN: 1179-1934
DOI
https://doi.org/10.2165/00023210-200822010-00005

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