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PharmacoEconomics
Published in: PharmacoEconomics 2/2009

01-02-2009 | Review Article

Effectiveness and Cost Effectiveness of Human Papillomavirus Vaccine

A Systematic Review

Authors: Dr Fawziah Marra, Karine Cloutier, Bridgette Oteng, Carlo Marra, Gina Ogilvie

Published in: PharmacoEconomics | Issue 2/2009

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Abstract

The recent approval of human papillomavirus (HPV) vaccine means that decision makers need information beyond that available from randomized clinical trials to recommend funding for this vaccination programme. Modelling and economic studies have addressed some of those information needs. We conducted a qualitative systematic review to summarize the existing data. Review articles were obtained from an extensive literature search on studies using mathematical modelling (either a Markov or transmission dynamic model) to determine the effectiveness or cost effectiveness of an HPV vaccine compared with the current cytology-based Pap smear screening programme.
A total of 21 studies (but 22 models) were included in the review after being assessed for methodological quality. All of the included studies had used a mathematical model to determine the effectiveness of an HPV vaccine, whilst 13 had also conducted a cost-effectiveness analysis. Although the studies used different model structures, baseline parameters and assumptions, all studies showed that vaccination would decrease rates of HPV infection, precancerous lesions and cervical cancer. Studies had a consistent message with respect to cost effectiveness: a female-only vaccination programme is cost effective compared with the current cytology-based Pap smear screening programme, while the cost effectiveness of a male and female vaccination programme is generally not cost effective compared with female-only vaccination.
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Metadata
Title
Effectiveness and Cost Effectiveness of Human Papillomavirus Vaccine
A Systematic Review
Authors
Dr Fawziah Marra
Karine Cloutier
Bridgette Oteng
Carlo Marra
Gina Ogilvie
Publication date
01-02-2009
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 2/2009
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200927020-00004

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