Skip to main content
Top
Published in: PharmacoEconomics 7/2005

01-07-2005 | Current Opinion

Price differentiation and transparency in the global pharmaceutical marketplace

Author: Dr David B. Ridley

Published in: PharmacoEconomics | Issue 7/2005

Login to get access

Abstract

Pharmaceutical manufacturers have increased the availability of their products and sometimes increased their own financial returns by charging lower prices outside of the US and by discounting to lower-income patients in the US. Examples include discounted HIV-AIDS drugs in developing countries and pharmaceutical manufacturers’ discount cards in the US. Representatives of some international organisations argue that the price reductions are insufficient to make the medications widely available to lower-income patients.
The WHO advocates both differential pricing and price transparency. While its efforts are well meaning, this paper identifies six concerns about its methods of comparing the price of a given molecule across manufacturers and across countries. More significantly, the WHO efforts to increase transparency are likely to lead to less price differentiation and less access to innovative pharmaceuticals. An important reason why manufacturers are reluctant to charge lower prices in lower-income countries is that they fear that such low prices will undermine the prices they charge to higher-income consumers. International organisations should not facilitate transparency but should dissuade governments from making price comparisons and basing their prices on those of lower-income countries. Furthermore, they should endeavour to keep low-priced and free drugs in the hands of the low-income consumers for which they were intended.
Footnotes
1
The typical rationales for patents are that they promote innovation, encourage inventors to disclose their inventions to others, and that inventors are entitled to their discoveries.
 
2
DiMasi et al.[12] found that the out-of-pocket cost per new drug is $US403 million (2000 value). After accounting for the compound’s share of failures and the opportunity cost of investing in R&D rather than earning a risk-free rate of return, the estimate is $US802 million. For an estimate of rates of return for pharmaceutical manufacturers, see Grabowski et al.[13]
 
3
It would be profitable for manufacturers to differentiate between patients in a given country, but because of the role of the government as a monopsony buyer, manufacturers are often unable to do so.
 
4
Demand for drugs is assumed to be more price elastic for patients with lower incomes. Furthermore, the cost of manufacturing is assumed to be lower than the poor consumer’s willingness to pay. If the cost of manufacturing exceeds the poor consumer’s willingness to pay, then it might be best to choose different products or subsidise treatment.
 
5
In the US, the top half of all earners paid 96% of federal income taxes in 2001.[15]
 
6
Manufacturers also express concerns about the lack of infrastructure in many developing countries. If HIV/AIDS patients do not adhere to a rigid schedule for taking their medicines, then they can spread drug resistance. A well known call by 133 Harvard faculty members advocates ‘directly observed therapy’ in which a community health worker visits each patient and observes him or her taking the antiretroviral medication.[2]
 
7
Furthermore, the manufacturer often prefers that the consumer not be informed of the differential pricing structure, so that higher-paying consumers do not search for arbitrage opportunities. For an analysis of the impact of the Internet on differential pricing, see Ridley and Schulman.[17]
 
8
For a survey of other policies by international organisations that would enhance patient health in developing countries, see Kremer[2].
 
9
Currently, parallel trade has little impact on drug costs in the US. Instead, state governments control drug costs using mechanisms such as prior authorisation, drug category exclusions and increased patient charges. Soumerai[31] describes the risks and benefits of such cost controls.
 
Literature
1.
go back to reference Lichtenberg FR. The impact of new drug launches on longevity: evidence from longitudinal, disease-level data from 52 countries, 1982–2001. National Bureau of Economic Research (NBER) Working Paper 9754, Jun 2003 Lichtenberg FR. The impact of new drug launches on longevity: evidence from longitudinal, disease-level data from 52 countries, 1982–2001. National Bureau of Economic Research (NBER) Working Paper 9754, Jun 2003
3.
go back to reference Lopert R, Lang DL, Hill SR, et al. Differential pricing of drugs: a role for cost-effectiveness analysis? Lancet 2002; 359 (9323): 2105–7PubMedCrossRef Lopert R, Lang DL, Hill SR, et al. Differential pricing of drugs: a role for cost-effectiveness analysis? Lancet 2002; 359 (9323): 2105–7PubMedCrossRef
4.
go back to reference Quick JD. Ensuring access to essential medicines in the developing countries: a framework for action. Clin Pharmacol Ther 2003; 73 (4): 279–83PubMedCrossRef Quick JD. Ensuring access to essential medicines in the developing countries: a framework for action. Clin Pharmacol Ther 2003; 73 (4): 279–83PubMedCrossRef
5.
go back to reference World Health Organization and Health Action International. Medicine prices: a new approach to measurement 2003 [online]. Available from URL: http://www.haiweb.org/medicine prices/manual/manuals/MedicinePrices.pdf [Accessed 2004 Aug 14] World Health Organization and Health Action International. Medicine prices: a new approach to measurement 2003 [online]. Available from URL: http://​www.​haiweb.​org/​medicine prices/manual/manuals/MedicinePrices.pdf [Accessed 2004 Aug 14]
6.
go back to reference World Health Organization and Health Action International. Medicine prices: a new approach to measurement 2004 [online]. Available from URL: http://www.haiweb.org/medicine prices/manual/manuals/MedicinePricesManualBrochure.pdf [Accessed 2004 Aug 14] World Health Organization and Health Action International. Medicine prices: a new approach to measurement 2004 [online]. Available from URL: http://​www.​haiweb.​org/​medicine prices/manual/manuals/MedicinePricesManualBrochure.pdf [Accessed 2004 Aug 14]
7.
go back to reference Sclar DA, Robison LM, Skaer TL, et al. International expenditure projections for pharmacotherapeutic advances in the treatment of HIV/AIDS. Clin Ther 1997; 19 (1): 86–95PubMedCrossRef Sclar DA, Robison LM, Skaer TL, et al. International expenditure projections for pharmacotherapeutic advances in the treatment of HIV/AIDS. Clin Ther 1997; 19 (1): 86–95PubMedCrossRef
8.
go back to reference Waldholz M, Zimmerman R. Bristol-Myers offers to sell two AIDS drugs in Africa at below cost. The Wall Street Journal 2001 Mar 15, B1 Waldholz M, Zimmerman R. Bristol-Myers offers to sell two AIDS drugs in Africa at below cost. The Wall Street Journal 2001 Mar 15, B1
9.
go back to reference Harris G, Waldholz M. AIDS drug plan spurs call to cut prices elsewhere. The Wall Street Journal 2000 May 12, B1 Harris G, Waldholz M. AIDS drug plan spurs call to cut prices elsewhere. The Wall Street Journal 2000 May 12, B1
10.
go back to reference Berndt ER. American Enterprise Institute monograph, Uniform pharmaceutical pricing: an economic analysis, Washington, DC: American Enterprise Institute, 1994 Berndt ER. American Enterprise Institute monograph, Uniform pharmaceutical pricing: an economic analysis, Washington, DC: American Enterprise Institute, 1994
11.
go back to reference Viscusi WK, Vernon JM, HarringtonJr JE. Economics of regulation and antitrust. 2nd ed. Cambridge (MA): The MIT Press, 1995 Viscusi WK, Vernon JM, HarringtonJr JE. Economics of regulation and antitrust. 2nd ed. Cambridge (MA): The MIT Press, 1995
12.
go back to reference DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ 2003; 22: 151–85PubMedCrossRef DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ 2003; 22: 151–85PubMedCrossRef
13.
go back to reference Grabowski HG, Vernon JM, DiMasi JA. Returns on research and development for 1990s new drug introductions. Pharmacoeconomics 2002; 20 Suppl. 3: 11–29PubMedCrossRef Grabowski HG, Vernon JM, DiMasi JA. Returns on research and development for 1990s new drug introductions. Pharmacoeconomics 2002; 20 Suppl. 3: 11–29PubMedCrossRef
14.
go back to reference Varian HR. Price discrimination. In: Schmalensee R, Willig RD, editors. Handbook of industrial organization. Amsterdam: Elsevier, 1989: 1, 597–654CrossRef Varian HR. Price discrimination. In: Schmalensee R, Willig RD, editors. Handbook of industrial organization. Amsterdam: Elsevier, 1989: 1, 597–654CrossRef
15.
go back to reference The rich recession. The Wall Street Journal 2003 Sep 30; Sect. A: 20 The rich recession. The Wall Street Journal 2003 Sep 30; Sect. A: 20
16.
go back to reference Dyer O. Cost price drugs for developing countries are found in Belgian pharmacies. BMJ 2002; 325: 794PubMedCrossRef Dyer O. Cost price drugs for developing countries are found in Belgian pharmacies. BMJ 2002; 325: 794PubMedCrossRef
17.
go back to reference Ridley DB, Schulman KA. Differential pricing of pharmaceuticals in the intemet age. J Ambul Care Manage 2004; 27 (3): 210–4PubMed Ridley DB, Schulman KA. Differential pricing of pharmaceuticals in the intemet age. J Ambul Care Manage 2004; 27 (3): 210–4PubMed
18.
go back to reference Central Intelligence Agency. The World Factbook [online]. Available from URL: http://www.cia.gov/cia/publications/factbook/ [Accessed 2004 Aug 14] Central Intelligence Agency. The World Factbook [online]. Available from URL: http://​www.​cia.​gov/​cia/​publications/​factbook/​ [Accessed 2004 Aug 14]
19.
go back to reference Kaufman M. Shalala halts bid to lower drug costs: reimportation bill’s ‘fatal flaws’ cited. Washington Post. 2000 Dee 27; Page A01 [online]. Available from URL: http://www.washingtonpost.com/ac2/wp-dyn/A52588-2000Dec26 [Accessed 2005 Apr 1] Kaufman M. Shalala halts bid to lower drug costs: reimportation bill’s ‘fatal flaws’ cited. Washington Post. 2000 Dee 27; Page A01 [online]. Available from URL: http://​www.​washingtonpost.​com/​ac2/​wp-dyn/​A52588-2000Dec26 [Accessed 2005 Apr 1]
20.
go back to reference US Dept of Health and Human Services response to Sen. James Jeffords on drug reimportation 2001 Jul 9 [online]. Available from URL: http://www.fda.gov/oc/po/thompson/medsact.html [Accessed 2005 Apr 1] US Dept of Health and Human Services response to Sen. James Jeffords on drug reimportation 2001 Jul 9 [online]. Available from URL: http://​www.​fda.​gov/​oc/​po/​thompson/​medsact.​html [Accessed 2005 Apr 1]
21.
go back to reference Price differences in Europe: the flaw of one price. The Economist 2003 Oct 18; 97 Price differences in Europe: the flaw of one price. The Economist 2003 Oct 18; 97
22.
go back to reference Danzon PM, Ketcham JD. Reference pricing of pharmaceuticals for Medicare: evidence from Germany, The Netherlands, and New Zealand. National Bureau of Economic Research (NBER) Working Paper 10007, Sep 2003 Danzon PM, Ketcham JD. Reference pricing of pharmaceuticals for Medicare: evidence from Germany, The Netherlands, and New Zealand. National Bureau of Economic Research (NBER) Working Paper 10007, Sep 2003
23.
go back to reference Schneeweiss S, Dormuth C, Grootendorst P, et al. Net health plan savings from reference pricing for angiotensin-converting enzyme inhibitors in elderly British Columbia residents. Med Care 2004; 42 (7): 653–60PubMedCrossRef Schneeweiss S, Dormuth C, Grootendorst P, et al. Net health plan savings from reference pricing for angiotensin-converting enzyme inhibitors in elderly British Columbia residents. Med Care 2004; 42 (7): 653–60PubMedCrossRef
24.
go back to reference Danzon P, Wang YR, Wang L. The impact of price regulation on the launch delay of new drugs: a study of twenty-five major markets in the 1990s. National Bureau of Economic Research (NBER) Working Paper 9874, 2003 Danzon P, Wang YR, Wang L. The impact of price regulation on the launch delay of new drugs: a study of twenty-five major markets in the 1990s. National Bureau of Economic Research (NBER) Working Paper 9874, 2003
26.
go back to reference Scott Morton F. The strategic response by pharmaceutical firms to the Medicaid most-favored-customer rules. RAND J Econ 1997; 28: 269–90PubMedCrossRef Scott Morton F. The strategic response by pharmaceutical firms to the Medicaid most-favored-customer rules. RAND J Econ 1997; 28: 269–90PubMedCrossRef
27.
29.
go back to reference Danzon PM, Kim JD. International price comparisons for pharmaceuticals. Pharmacoeconomics 1998; 14 Suppl. 1: 115–28PubMedCrossRef Danzon PM, Kim JD. International price comparisons for pharmaceuticals. Pharmacoeconomics 1998; 14 Suppl. 1: 115–28PubMedCrossRef
30.
go back to reference Munro GR, Scott AD. The economics of fisheries management. In: Kneese AV, Sweeney JL, editors. Handbook of natural resources and energy economics. Amsterdam: Elsevier, 1985, 2 Munro GR, Scott AD. The economics of fisheries management. In: Kneese AV, Sweeney JL, editors. Handbook of natural resources and energy economics. Amsterdam: Elsevier, 1985, 2
31.
go back to reference Soumerai SB. Benefits and risks of increasing restrictions on access to costly drugs in Medicaid. Health Aff 2004; 23 (1): 135–46CrossRef Soumerai SB. Benefits and risks of increasing restrictions on access to costly drugs in Medicaid. Health Aff 2004; 23 (1): 135–46CrossRef
32.
go back to reference Ratanawijitrasin S, Soumerai SB, Weerasuriya K. Do national medicinal drug policies and essential drug programs improve drug use? A review of experiences in developing countries. Soc Sci Med 2001; 53 (7): 831–44PubMedCrossRef Ratanawijitrasin S, Soumerai SB, Weerasuriya K. Do national medicinal drug policies and essential drug programs improve drug use? A review of experiences in developing countries. Soc Sci Med 2001; 53 (7): 831–44PubMedCrossRef
Metadata
Title
Price differentiation and transparency in the global pharmaceutical marketplace
Author
Dr David B. Ridley
Publication date
01-07-2005
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 7/2005
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200523070-00002

Other articles of this Issue 7/2005

PharmacoEconomics 7/2005 Go to the issue