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Published in:

01-06-2008 | Review Article

Improving Delivery of Aminosalicylates in Ulcerative Colitis

Effect on Patient Outcomes

Authors: Nielsen Q. Fernandez-Becker, Dr Alan C. Moss

Published in: Drugs | Issue 8/2008

Abstract

Developments in drug delivery technology have expanded the formulations of 5-aminosalicylic acid (5-ASA) available to clinicians over the last 50 years. Delivery of adequate doses of 5-ASA to the colon can be achieved by pH-dependent, delayed-release or pro-drug formulations. Despite some variations in the pharmacokinetics between individual preparations, the clinical effects in induction of response and maintenance of remission in ulcerative colitis appear to be consistent. Direct comparison studies between different preparations haveyielded similar results in primary endpoints, although differences in secondary endpoints or post hoc analyses have been noted. The development of delivery methods that allow once-daily administration represents a potential means to improve the low medication adherence rates reported in patients with ulcerative colitis.

The use of trade names is for product identification purposes only and does not imply endorsement.

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Title: Improving Delivery of Aminosalicylates in Ulcerative Colitis
Effect on Patient Outcomes
Authors: Nielsen Q. Fernandez-Becker
Dr Alan C. Moss
Publication date: 01-06-2008
Publisher: Springer International Publishing
Published in: Drugs / Issue 8/2008
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.2165/00003495-200868080-00006

At a glance: The STEP trials

Springer Medicine

Improving Delivery of Aminosalicylates in Ulcerative Colitis

Effect on Patient Outcomes

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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