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Published in: Drugs 2/2001

01-02-2001 | Adis New Drug Profile

Omalizumab

Authors: Stephanie Easthope, Blair Jarvis

Published in: Drugs | Issue 2/2001

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Abstract

  • ▴ Omalizumab is a recombinant humanised monoclonal antibody which specifically binds to the Cε3 domain of immunoglobulin (Ig) E, the site of high-affinity IgE receptor binding.
  • ▴ Improvements in asthma symptoms and health-related quality-of-life, and a significant reduction in the frequency of asthma exacerbations were seen in allergic asthmatic patients treated with omalizumab.
  • ▴ Omalizumab was also effective in the treatment of children with allergic asthma demonstrating improvements in health-related quality-of-life and significant dosage reductions of inhaled corticosteroids.
  • ▴ Administration of omalizumab to patients with allergic rhinitis resulted in a rapid dose-dependent suppression of serum free IgE levels.
  • ▴ Omalizumab significantly improved health-related quality-of-life and nasal symptoms in patients with seasonal allergicrhinitis.Antihistaminerequirements were also significantly reduced following treatment.
  • ▴ Adverse events were infrequent in clinical trials of omalizumab, and not significantly different from placebo. The most frequent drug-related event was mild to moderate urticaria.
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Metadata
Title
Omalizumab
Authors
Stephanie Easthope
Blair Jarvis
Publication date
01-02-2001
Publisher
Springer International Publishing
Published in
Drugs / Issue 2/2001
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.2165/00003495-200161020-00008

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