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Clinical Pharmacokinetics
Published in: Clinical Pharmacokinetics 3/2009

01-03-2009 | Review Article

Sex Differences in Pharmacokinetics and Pharmacodynamics

Authors: Dr Offie P. Soldin, Donald R. Mattison

Published in: Clinical Pharmacokinetics | Issue 3/2009

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Abstract

Significant differences that exist between the sexes affect the prevalence, incidence and severity of a broad range of diseases and conditions. Men and women also differ in their response to drug treatment. It is therefore essential to understand these reactions in order to appropriately conduct risk assessment and to design safe and effective treatments. Even from that modest perspective, how and when we use drugs can result in unwanted and unexpected outcomes. This review summarizes the sex-based differences that impact on pharmacokinetics, and includes a general comparison of clinical pharmacology as it applies to men, women and pregnant women. Sex-related or pregnancy-induced changes in drug absorption, distribution, metabolism and elimination, when significant, may guide changes in dosage regimen or therapeutic monitoring to increase its effectiveness or reduce potential toxicity. Given those parameters, and our knowledge of sex differences, we can derive essentially all factors necessary for therapeutic optimization.
Since this is a rapidly evolving area, it is essential for the practitioner to review drug prescribing information and recent literature in order to fully understand the impact of these differences on clinical therapeutics.
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Metadata
Title
Sex Differences in Pharmacokinetics and Pharmacodynamics
Authors
Dr Offie P. Soldin
Donald R. Mattison
Publication date
01-03-2009
Publisher
Springer International Publishing
Published in
Clinical Pharmacokinetics / Issue 3/2009
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI
https://doi.org/10.2165/00003088-200948030-00001

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