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Clinical Pharmacokinetics

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01-03-2008 | Original Research Article

Application of Basic Pharmacokinetic Concepts to Analysis of Microdialysis Data

Illustration with Imipenem Muscle Distribution

Authors: Claire Dahyot, Sandrine Marchand, Mikael Bodin, Bertrand Debeane, Olivier Mimoz, Dr William Couet

Published in: Clinical Pharmacokinetics | Issue 3/2008

Abstract

Background: Microdialysis studies of antibacterial tissue distribution in critically ill patients have sometimes led to results that were spectacular but inconsistent with basic pharmacokinetic concepts.

Objective: To conduct a study of imipenem distribution in the muscle of healthy volunteers and critical care patients in order to compare real-life data with theory.

Methods: Microdialysis catheters were placed into the quadriceps, and probe recoveries were determined individually in vivo using a retrodialysis-by-drug method. Unbound imipenem concentrations were determined by high-performance liquid chromatography in plasma ultrafiltrates and muscle dialysates, and submitted to noncompartmental pharmacokinetic analysis.

Results: Individual unbound imipenem concentrations in plasma and muscle extracellular fluid were virtually superimposed at any time, both in healthy volunteers and in critical care patients.

Conclusion: These new results are not consistent with previously published data obtained in similar conditions by another group, but they are in agreement with results previously obtained in rats, as well as being consistent with basic pharmacokinetic concepts.

The use of trade names is for product identification purposes only and does not imply endorsement.

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Title: Application of Basic Pharmacokinetic Concepts to Analysis of Microdialysis Data
Illustration with Imipenem Muscle Distribution
Authors: Claire Dahyot
Sandrine Marchand
Mikael Bodin
Bertrand Debeane
Olivier Mimoz
Dr William Couet
Publication date: 01-03-2008
Publisher: Springer International Publishing
Published in: Clinical Pharmacokinetics / Issue 3/2008
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI: https://doi.org/10.2165/00003088-200847030-00004

At a glance: The STEP trials

Springer Medicine

Application of Basic Pharmacokinetic Concepts to Analysis of Microdialysis Data

Illustration with Imipenem Muscle Distribution

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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