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Clinical Pharmacokinetics

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01-01-2006 | Commentary

‘Hedged’ Prescribing for Partially Compliant Patients

How Accurate Are Available Scaling Methods?

Authors: John Urquhart, Bernard Vrijens

Published in: Clinical Pharmacokinetics | Issue 1/2006

Excerpt

The term ‘hedge’ has multiple meanings; its use here is analogous to its meaning in financial markets, i.e. ‘to protect oneself from losing or failing by a counterbalancing action’.[1] The paper by Blesius et al.[2] strives to achieve a therapeutically useful degree of ‘counterbalancing action’ in the prescribing of oral anticoagulants by switching between either of two available drugs and/or between once- and twice-daily dosing. Their approach deserves attention and consideration for extension into other fields of ambulatory pharmacotherapy as a risk-management tool. …

The use of trade names is for product identification purposes only and does not imply endorsement.

Merriam-Webster’s Collegiate Dictionary, 10th ed. Springfield (MA): Merriam-Webster, Inc., 2001

Blesius A, Chabaud S, Cucherat M, et al. Compliance-guided therapy: a new insight into the potential role of clinical pharmacologists. Clin Pharmacokinet 2005; 45(1): 95–104CrossRef

Urquhart J. Variable compliance and persistence with prescribed drug dosing regimens: implications for benefits, risks, and economics of pharmacotherapy. In: Strom B, editor. Pharmacoepidemiology. 4th ed. Chichester: John Wiley, 2005: 767–89

Potter LS. Oral contraceptive compliance and its role in the effectiveness of the method. In: Cramer JA, Spilker B, editors. Compliance in medical practice and clinical trials. New York: Raven Press, 1991: 195–207

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“What to do if you miss pills”? In: Physicians’ desk reference. 59th ed. Montvale (NJ): Medical Economics Co.: 2541

Ten great public health achievements US, 1900–99: family planning. MMWR 1999; 48: 1073-80

Urquhart J. The odds of the three nons when an aptly prescribed medicine isn’t working: noncompliance, nonabsorption, non-response. Brit J Clin Pharmacol 2002; 54: 212–20CrossRef

Urquhart J. Controlled drug delivery: pharmacologic and therapeutic aspects. J Internal Med 2000; 248: 357–76PubMedCrossRef

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Vrijens B, Gross R, Urquhart J. The odds that clinically unrecognized poor or partial adherence confuses population pharmacokinetic/pharmacodynamic analyses. Basic Clin Pharmacol Toxicol 2005; 96: 225–7PubMedCrossRef

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Vrijens B, Comte L, Tousset E, et al. Once-daily versus twice-daily regimens: which is best for HIV-infected patients [abstract no. 3; poster no. 1.3]. 6th International Workshop on Clinical Pharmacology of HIV Therapy. 2005 Apr 28–30. Quebec City (QC)

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Levy G. A pharmacokinetic perspective on medicament non-compliance. Clin Pharmacol Ther 1993; 54: 242–4PubMedCrossRef

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Title: ‘Hedged’ Prescribing for Partially Compliant Patients
How Accurate Are Available Scaling Methods?
Authors: John Urquhart
Bernard Vrijens
Publication date: 01-01-2006
Publisher: Springer International Publishing
Published in: Clinical Pharmacokinetics / Issue 1/2006
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI: https://doi.org/10.2165/00003088-200645010-00008

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

‘Hedged’ Prescribing for Partially Compliant Patients

How Accurate Are Available Scaling Methods?

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

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Pharmacokinetics and Pharmacodynamics of the Oral Direct Thrombin Inhibitor Ximelagatran in Young Healthy Japanese Men

Compliance-Guided Therapy

Mass Balance Studies, with a Focus on Anticancer Drugs

Significance of the Minor Cytochrome P450 3A Isoforms

Population Pharmacokinetics of Tacrolimus in Whole Blood and Plasma in Asian Liver Transplant Patients

Prediction of Cytochrome P450-Mediated Hepatic Drug Clearance in Neonates, Infants and Children