The goal of antihypertensive therapy is to abolish the risk associated with blood pressure (BP) elevation without adversely affecting quality of life. Drug selection is based on efficacy in lowering BP and in reducing cardiovascular endpoints including stroke, myocardial infarction and heart failure. Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the primary determinant of cardiovascular risk reduction. …