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01-05-2011 | Review Article

Glatiramer Acetate in the Treatment of Multiple Sclerosis

Emerging Concepts Regarding its Mechanism of Action

Authors: Patrice H. Lalive, Oliver Neuhaus, Mahdia Benkhoucha, Danielle Burger, Reinhard Hohlfeld, Scott S. Zamvil, Dr Martin S. Weber

Published in: CNS Drugs | Issue 5/2011

Abstract

Glatiramer acetate is a synthetic, random copolymer widely used as a first-line agent for the treatment of relapsing-remitting multiple sclerosis (MS). While earlier studies primarily attributed its clinical effect to a shift in the cytokine secretion of CD4+ T helper (T_h) cells, growing evidence in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), suggests that glatiramer acetate treatment is associated with a broader immunomodulatory effect on cells of both the innate and adaptive immune system. To date, glatiramer acetate-mediated modulation of antigen-presenting cells (APC) such as monocytes and dendritic cells, CD4+ T_h cells, CD8+ T cells, Foxp3+ regulatory T cells and antibody production by plasma cells have been reported; in addition, most recent investigations indicate that glatiramer acetate treatment may also promote regulatory B-cell properties. Experimental evidence suggests that, among these diverse effects, a fostering interplay between anti-inflammatory T-cell populations and regulatory type II APC may be the central axis in glatiramer acetate-mediated immune modulation of CNS autoimmune disease. Besides altering inflammatory processes, glatiramer acetate could exert direct neuroprotective and/or neuroregenerative properties, which could be of relevance for the treatment of MS, but even more so for primarily neurodegenerative disorders, such as Alzheimer’s or Parkinson’s disease. In this review, we provide a comprehensive and critical overview of established and recent findings aiming to elucidate the complex mechanism of action of glatiramer acetate.

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Title: Glatiramer Acetate in the Treatment of Multiple Sclerosis
Emerging Concepts Regarding its Mechanism of Action
Authors: Patrice H. Lalive
Oliver Neuhaus
Mahdia Benkhoucha
Danielle Burger
Reinhard Hohlfeld
Scott S. Zamvil
Dr Martin S. Weber
Publication date: 01-05-2011
Publisher: Springer International Publishing
Published in: CNS Drugs / Issue 5/2011
Print ISSN: 1172-7047
Electronic ISSN: 1179-1934
DOI: https://doi.org/10.2165/11588120-000000000-00000

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Glatiramer Acetate in the Treatment of Multiple Sclerosis

Emerging Concepts Regarding its Mechanism of Action

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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