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Drugs
Published in: Drugs 1/2010

01-01-2010 | Review Article

Attention-Deficit Hyperactivity Disorder

Recent Advances in Paediatric Pharmacotherapy

Authors: Diane E. May, Professor Christopher J. Kratochvil

Published in: Drugs | Issue 1/2010

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Abstract

Throughout this decade, there has been significant research into pharmacotherapies for attention-deficit hyperactivity disorder (ADHD). This article considers the efficacy and safety of five of the more novel long-acting pharmacological treatments recently approved by the FDA for marketing in the US for paediatric ADHD, along with an α2-adrenoceptor agonist in preparation. Reviewed treatments include the non-stimulant atomoxetine, three novel extended-release (XR) stimulant preparations: dexmethylphenidate, lisdexamfetamine dimesylate and the methylphenidate transdermal system (TDS), and the recently approved XR α2-adrenoceptor agonist, guanfacine.
Dexmethylphenidate XR is a stimulant treatment in a single isomer form, and has an efficacy and tolerability similar to two doses of immediate-release (IR) dexmethylphenidate when taken 4 hours apart, but is dosed at half of the usual d,l-methylphenidate dose. Dexmethylphenidate XR utilizes a beaded bimodal release, with 50% initially released and another 50% released 4 hours later to provide benefit lasting up to 10–12 hours.
Lisdexamfetamine was the first stimulant treatment approved as a prodrug, whereby the single isomer d-amfetamine remains pharmacologically inactive until activated by cleaving the lysine. Its efficacy and tolerability are generally consistent with that of XR mixed amfetamine salts, with this activation method and more consistent absorption generally resulting in up to an 11- to 13-hour benefit.
The methylphenidate TDS patch utilizes skin absorption to provide predictable and uniform delivery of methylphenidate when worn for 9 hours/day. The efficacy and tolerability of the methylphenidate TDS patch is generally consistent with that of osmotic-controlled release oral system (OROS®) methylphenidate, providing benefit for about 11–12 hours. Because of their formulation, lisdexamfetamine and methylphenidate each have an onset of effect at about 2 hours after administration. An adjustable wear time for the methylphenidate TDS patch accommodates related adverse effects, but its disadvantages are frequent skin irritation and the need to remember to take the patch off.
Atomoxetine is the first non-stimulant treatment approved by the FDA and employs weight-based dosing up to 1.4 mg/kg/day. Benefit is generally observed within 2–8 weeks of initiation and is considered to have a lesser therapeutic effect than that of stimulants. A recent parallel-group controlled study found that atomoxetine (up to 1.8 mg/kg/day) and OROS® methylphenidate both improved ADHD symptoms, although subjects receiving OROS® methylphenidate had a significantly better response. Interestingly, treatment-naive children had a similar beneficial response to atomoxetine as those receiving OROS® methylphenidate. Subsequent crossover treatment revealed a subgroup of youths who did not respond well to OROS® methylphenidate but did respond to atomoxetine. Also identified was a larger than expected subgroup who did not respond well to either active treatment, confirming the need to continue the pursuit of novel treatments.
As of September of 2009, guanfacine in XR form is the first α2-adrenoceptor agonist to gain approval to treat ADHD, approved for the treatment of 6- to 17-year olds. A second α2-adrenoceptor agonist, clonidine, is in development as a potential XR treatment for paediatric ADHD. IR clonidine has a fast onset and short half-life, with its use historically limited by somnolence. Although early formulations did not improve inattention well, recent evidence suggests that clonidine XR may have potential use as monotherapy or in extending benefit when taken with a stimulant. Guanfacine has a more specific neuronal action and a longer action than that of clonidine. The approved dosing of guanfacine XR 1 to 4 mg daily generally provides symptom benefit lasting 8–14 hours, and up to 24 hours in some children and adolescents receiving a higher dose.
Such recent developments and ongoing study of additional potential pharmacological interventions may lead to additional future treatment options for children with ADHD.
Literature
1.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Text rev, 4th ed. Washington, DC: American Psychiatric Association, 2000
2.
American Academy of Pediatrics, Subcommittee on Attention-Deficit/Hyperactivity Disorder and Committee on Quality Improvement. Clinical practice guideline: treatment of the school-aged child with attention-deficit/ hyperactivity disorder. Pediatrics 2001 Oct; 108(4): 1033–44
3.
American Academy of Pediatrics Committee on Quality Improvement and Subcommittee on Attention-Deficit/ Hyperactivity Disorder. Treatment of attention deficit/ hyperactivity disorder: overview of the evidence. Pediatrics 2005 Jun; 115(6): E749–57
4.
Greenhill LL, Pliszka S, Dulcan MK, et al. American Academy of Child and Adolescent Psychiatry. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 2002 Feb; 41 (2 Suppl.): 26–49S
5.
Pliszka S. AACAP Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2007 Jul; 46(7): 894–921PubMed
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
Biederman J, Spencer TJ. Psychopharmacological interventions. Child Adolesc Psychiatr Clin N Am 2008 Apr; 17(2): 439–58PubMed
18.
Brams M, Mao AR, Doyle RL. Onset of efficacy of long-acting psychostimulants in pediatric attention-deficit/ hyperactivity disorder. Postgrad Med 2008 Sep; 120(3): 69–88PubMed
19.
Findling RL. Evolution of the treatment of attention-deficit/ hyperactivity disorder in children: a review. Clin Ther 2008 May; 30(5): 942–57PubMed
20.
Faraone SV, Biederman J, Spencer TJ, et al. Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med 2006 Oct; 8(4): 4
21.
Pelham WE, Greenslade KE, Vodde-Hamilton M, et al. Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release dextroamphetamine, and pemoline. Pediatrics 1990 Aug; 86(2): 226–37PubMed
22.
Pelham WE, Gnagy EM, Chronis AM, et al. A comparison of morning-only and morning/late afternoon adderall to morning-only, twice-daily, and three times-daily methylphenidate in children with attention-deficit/hyperactivity disorder. Pediatrics 1999 Dec; 104(6): 1300–11PubMed
23.
Smith BH, Pelham WE, Gnagy E, et al. Equivalent effects of stimulant treatment for attention-deficit hyperactivity disorder during childhood and adolescence. J Am Acad Child Adolesc Psychiatry 1998 Mar; 37(3): 314–21PubMed
24.
Swanson JM, Wigal SB, Wigal T, et al., COMACS Study Group. A comparison of once-daily extended-release methylphenidate formulations in children with attention deficit/hyperactivity disorder in the laboratory school (The Comacs Study). Pediatrics 2004 Mar; 113(3): E206–16PubMed
25.
Barbaresi WJ, Katusic SK, Colligan RC, et al. Modifiers of long-term school outcomes for children with attention-deficit/hyperactivity disorder: does treatment with stimulant medication make a difference? Results from a population-based study. J Dev Behav Pediatr 2007 Aug; 28(4): 274–87PubMed
26.
Barkley RA, Fischer M, Edelbrock CS, et al. The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 1990 Oct; 29(5): 546–57PubMed
27.
Biederman J, Monuteaux MC, Spencer T, et al. Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up study. Pediatrics 2009 Jul; 124(1): 71–8PubMed
28.
Charles L, Schain R. A four-year follow-up study of the effects of methylphenidate on the behavior and academic achievement of hyperactive children. J Abnorm Child Psychol 1981 Dec; 9(4): 495–505PubMed
29.
Hanć T, Cieślik J. Growth in stimulant-naive children with attention-deficit/hyperactivity disorder using cross-sectional and longitudinal approaches. Pediatrics 2008 Apr; 121(4): E967–74PubMed
30.
Hammerness P, Wilens T, Mick E, et al. Cardiovascular effects of longer-term, high-dose OROS methylphenidate in adolescents with attention deficit hyperactivity disorder. J Pediatr 2009 Jul; 155(1): 84–9PubMed
31.
Molina BS, Hinshaw SP, Swanson JM, et al. The MTA at 8 years: prospective follow-up of youths treated for combined-type ADHD in a multisite study. J Am Acad Child Adolesc Psychiatry 2009 May; 48(5): 484–500PubMed
32.
Powers RL, Marks DJ, Miller CJ, et al. Stimulant treatment in children with attention-deficit/hyperactivity disorder moderates adolescent academic outcome. J Child Adolesc Psychopharmacol 2008 Oct; 18(5): 449–59PubMed
33.
Hinshaw SP, Owens EB, Sami N, et al. Prospective follow-up of girls with attention-deficit/hyperactivity disorder into adolescence: evidence for continuing cross-domain impairment. J Consult Clin Psychol 2006 Jun; 74(3): 489–99PubMed
34.
Biederman J, Monuteaux MC, Spencer T, et al. Stimulant therapy and risk for subsequent substance use disorders in male adults with ADHD: a naturalistic controlled 10-year follow-up study. Am J Psychiatry 2008 May; 165(5): 597–603PubMed
35.
Brinker A, Mosholder A, Schech SD, et al. Indication and use of drug products used to treat attention-deficit/ hyperactivity disorder: a cross-sectional study with inference on the likelihood of treatment in adulthood. J Child Adolesc Psychopharmacol 2007 Jun; 17(3): 328–33PubMed
36.
Kessler RC, Adler LA, Barkley R, et al. Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication. Biol Psychiatry 2005 Jun 1; 57(11): 1442–51PubMed
37.
Lara C, Fayyad J, de Graaf R, et al. Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biol Psychiatry 2009 Jan; 65(1): 46–54PubMed
38.
Mannuzza S, Klein RG, Truong NL, et al. Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry 2008 May; 165(5): 604–9PubMed
39.
Tuerck D, Wang Y, Maboudian M, et al. Similar bioavailability of dexmethylphenidate extended (bimodal) release, dexmethyl-phenidate, immediate release and racemic methylphenidate extended (bimodal) release formulations in man. Int J Clin Pharmacol Ther 2007 Dec; 45(12): 662–8PubMed
40.
Quinn D, Wigal S, Swanson J, et al. Comparative pharmacodynamics and plasma concentrations of d-threo-methylphenidate hydrochloride after single doses of d-threo-methylphenidate hydrochloride and d,l-threomethylphenidate hydrochloride in a double-blind, placebo-controlled, crossover laboratory school study in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2004 Nov; 43(11): 1422–9PubMed
41.
42.
Davids E, Zhang K, Tarazi FI, et al. Stereoselective effects of methylphenidate on motor hyperactivity in juvenile rats induced by neonatal 6-hydroxydopamine lesioning. Psychopharmacology 2002 Feb; 160(1): 92–8PubMed
43.
Teo SK, Stirling DI, Thomas SD, et al. Neuro-behavioral effects of racemic threo-methylphenidate and its D and L enantiomers in rats. Pharmacol Biochem Behav 2003 Feb; 74(3): 747–54PubMed
44.
Fischer R, Schütz H, Grossmann M, et al. Bioequivalence of a methylphenidate hydrochloride extended-release preparation: comparison of an intact capsule and an opened capsule sprinkled on applesauce. Int J Clin Pharmacol Ther 2006 Mar; 44(3): 135–41PubMed
45.
Lee L, Kepple J, Wang Y, et al. Bioavailability of modified-release methylphenidate: influence of high-fat breakfast when administered intact and when capsule content sprinkled on applesauce. Biopharm Drug Dispos 2003 Sep; 24(6): 233–43PubMed
46.
Teo SK, Scheffler MR, Wu A, et al. A single-dose, two-way crossover, bioequivalence study of dexmethylphenidate HCl with and without food in healthy subjects. J Clin Pharm 2004 Feb; 44(2): 173–8
47.
Greenhill L, Muniz R, Ball RR, et al. Efficacy and safety of extended release dexmethylphenidate capsules in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2006 Jul; 45(7): 817–23PubMed
48.
Conners CK. A teacher rating scale for use in drug studies with children. Am J Psychiatry 1969 Dec; 126(6): 884–8PubMed
49.
Silva RR, Muniz R, Pestreich L, et al. Efficacy and duration of effect of extended release, dexmethylphenidate versus placebo in school children with attention-deficit/ hyperactivity disorder. J Child Adolesc Psychopharmacol 2006 Jun; 16(3): 239–51PubMed
50.
Silva RR, Muniz R, Pestreich L, et al. Dexmethylphenidate extended-release capsules in children with attention-deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2008 Feb; 47(2): 199–208PubMed
51.
Murray DW, Bussing R, Fernandez M, et al. Psychometric properties of teacher SKAMP ratings from a community sample. Assessment 2009 Jun; 16(2): 193–208PubMed
52.
Wigal S, Gupta S, Guinta D, et al. Reliability and validity of the SKAMP rating scale in a laboratory school setting. Psychopharmacol Bull 1998; 34(1): 47–53PubMed
53.
Brams M, Muniz R, Childress A, et al. A randomized, double-blind, crossover study of once-daily dexmethylphenidate in children with attention-deficit hyperactivity disorder: rapid onset of effect. CNS Drugs 2008 Oct; 22(8): 693–704PubMed
54.
Silva R, Muniz R, McCague K, et al. Treatment of children with attention-deficit/hyperactivity disorder: results of a randomized, multicenter, double-blind, crossover study of extended release dexmethylphenidate, d,l-methylphenidate and placebo in a laboratory classroom setting. Psychopharmacol Bull 2008; 41(1): 19–33PubMed
55.
Muniz R, Brams M, Mao A, et al. Efficacy and safety of extended release dexmethylphenidate compared with d,l-methylphenidate and placebo in the treatment of children with attention-deficit/hyperactivity disorder: a 12-hour laboratory classroom study. J Child and Adol Psychopharmacol 2008 Jun; 18(3): 248–56
56.
57.
Pierce D, Dixon CM, Wigal SB, et al. Pharmacokinetics of methylphenidate transdermal system (MTS): results from a laboratory classroom study. J Child Adolesc Psychopharmacol 2008 Aug; 18(4): 355–64PubMed
58.
González MA, Campbell D, Rubin J. Effects of application to two different skin sites on the pharmacokinetics of transdermal methylphenidate in pediatric patients with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2009 Jun; 19(3): 227–32PubMed
59.
Weiss M, Hechtman L, Turgay A, et al. Once-daily multilayer-release methylphenidate in a double-blind, crossover comparison to immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2007 Oct; 17(5): 675–88PubMed
60.
Findling RL, Bukstein OG, Melmed RD, et al. A randomized, double-blind, placebo-controlled, parallel-group study of methylphenidate transdermal system in pediatric patients with attention-deficit/hyperactivity disorder. J Clin Psychiatry 2008 Jan; 69(1): 149–59PubMed
61.
Wilens TE, Boellner SW, López FA, et al. Varying the wear time of the methylphenidate transdermal system in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2008 Jun; 47(6): 700–8PubMed
62.
Arnold LE, Lindsay RL, Lopez RA, et al. Treating attention-deficit/hyperactivity disorder with a stimulant transdermal patch: the clinical art. Pediatrics 2007 Nov; 120(5): 1100–58PubMed
63.
Pelham WE, Manos MJ, Ezzell CE, et al. A dose-ranging study of a methylphenidate transdermal system in children with ADHD. J Am Acad Child Adolesc Psychiatry 2005 Jun; 44(6): 522–9PubMed
64.
Pelham WE, Burrows-Maclean L, Gnagy EM, et al. Transdermal methyphenidate, behavioral, and combined treatment for children with ADHD. Exp Clin Psychopharmacol 2005 May; 13(2): 111–26PubMed
65.
McGough JJ, Wigal SB, Abikoff H, et al. A randomized, double-blind, placebo controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. J Atten Disord 2006 Feb; 9(3): 476–85PubMed
66.
Farone SV, Giefer EE. Long-term effects of methylphenidate transdermal delivery system treatment of ADHD on growth. J Am Acad Child Adolesc Psychiatry 2007 Sep; 46(9): 1138–47
67.
Guy W. ECDEU Assessment manual for psychopharmacology. 2nd ed. Washington, DC: US Government Printing Office, 1976. DHEW Publication no. ABM 76-388
68.
DuPaul GJ, Power TJ, Anastopoulos AD, et al. ADHD rating scale-IV: checklists, norms, and clinical interpretation. New York: Guilford Press, 1998
69.
Conners CK, Parker JD, Sitarenios G, et al. The revised Conners’ parent rating scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnormal Child Psychol 1998 Aug; 26(4): 257–68
70.
71.
Bangs ME, Jin L, Zhang S, et al. Hepatic events associated with atomoxetine treatment for attention-deficit hyperactivity disorder. Drug Saf 2008; 31(4): 345–54PubMed
72.
Warshaw EM, Paller AS, Fowler JF, et al. Practical management of cutaneous reactions to the methylphenidate transdermal system: recommendations from a dermatology expert panel consensus meeting. Clin Ther 2008 Feb; 30(2): 326–37PubMed
73.
MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: changes in effectiveness and growth after the end of treatment. Pediatrics 2004 Apr; 113(4): 762–9
74.
Swanson JM, Elliott GR, Greenhill LL, et al. Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. J Am Acad Child Adolesc Psychiatry 2007 Aug; 46(8): 1015–27PubMed
75.
Findling RL, Childress AC, Krishnan S, et al. Long-term effectiveness and safety of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder. CNS Spectr 2008 Jul; 13(7): 614–20PubMed
76.
Spencer TJ, Newcorn JH, Kratochvil CJ, et al. Effects of atomoxetine on growth after 2-year treatment among pediatric patients with attention-deficit/hyperactivity disorder. Pediatrics 2005 Jul; 116(1): E74–80PubMed
77.
Spencer TJ, Kratochvil CJ, Sangal RB, et al. Effects of atomoxetine on growth in children with attention-deficit/hyperactivity disorder following up to five years of treatment. J Child Adolesc Psychopharmacol 2007 Oct; 17(5): 689–700PubMed
78.
Faraone SV, Biederman J, Monuteaux M, et al. Long-term effects of extended-release mixed amphetamine salts treatment of attention-deficit/hyperactivity disorder on growth. J Child Adolesc Psychopharmacol 2005 Apr; 15(2): 191–202PubMed
79.
Wilens T, McBurnett K, Stein M, et al. ADHD treatment with once-daily OROS methylphenidate: final results from a long-term open-label study. J Am Acad Child Adolesc Psychiatry 2005 Oct; 44(10): 1015–23PubMed
80.
Charach A, Figueroa M, Chen S, et al. Stimulant treatment over 5 years: effects on growth. J Am Acad Child Adolesc Psychiatry 2006 Apr; 45(4): 415–21PubMed
81.
Pliszka SR, Matthews TL, Braslow KJ, et al. Comparative effects of methylphenidate and mixed salts amphetamine on height and weight in children with attention deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2006 May; 45(5): 520–6PubMed
82.
Jasinski DR, Krishnan S. Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J Psychopharmacol 2009 Jun; 23(4): 419–27PubMed
83.
McGough JJ, Biederman J, Greenhill LL, et al. Pharmacokinetics of SLI381 (Adderall XR), an extended-release formulation of Adderall. J Am Acad Child Adolesc Psychiatry 2003 Jun; 42(6): 684–91PubMed
84.
Krishnan S, Zhang Y. Relative bioavailability of lisdexamfetamoine 70-mg capsules in fasted and fed healthy adult volunteers and in solution: a single-dose, crossover pharmacokinetic study. J Clin Pharmacol 2008 Mar; 48(3): 293–302PubMed
85.
Biederman J, Boellner SW, Childress A, et al. Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study. Biol Psychiatry 2007 Nov; 62(9): 970–6PubMed
86.
Biederman J, Krishnan S, Zhang Y, et al. Efficacy and safety of lisdexamfeine (LDX; NRP104) in children with attention-deficit hyperactivity disorder: a phase 3, randomized, multicenter, double-blind, parallel-group study. Clin Ther 2007 Mar; 29(3): 450–63PubMed
87.
Wigal SB, Kollins SH, Childress AC, et al.; 311 Study Group. A 13-hour laboratory school study of lisdexamfetamine dimesylate in school-aged youths with attention-deficit/hyperactivity disorder. Child Adolesc Psychiatry Ment Health 2009 Jun; 3(1): 17PubMed
88.
Easton N, Marshall F, Fone KC, et al. Differential effects of the d- and l-isomers of amphetamine on pharmacological MRI BOLD contrast in the rat. Psychopharmacology (Berl) 2007 Jul; 193(1): 11–30
89.
Sagvolden T, Xu T. l-Amphetamne improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of attention-deficit/hyperactivity disorder (ADHD). Behav Brain Funct 2008 Jan; 4: 3PubMed
90.
Glaser PE, Thomas TC, Joyce BM, et al. Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core. Psychopharmacology (Berl) 2005 Mar; 178(2–3): 250–8
91.
Joyce BM, Glaser PE, Gerhardt GA. Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Psychopharmacology (Berl) 2007 Apr; 191(3): 669–77
92.
Witcher JW, Long A, Smith B, et al. Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2003 Spring; 13(1): 53–63PubMed
93.
Michelson D, Read HA, Ruff DD, et al. CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 2007 Feb; 46(2): 242–51PubMed
94.
Trzepacz PT, Williams DW, Feldman PD, et al. CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD. Eur Neuropsychopharmacol 2008 Feb; 18(2): 79–86PubMed
95.
Wee S, Woolverton WL. Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine. Drug Alcohol Depend 2004 Sep; 75(3): 271–6PubMed
96.
Jasinski DR, Faries DE, Moore RJ, et al. Abuse liability assessment of atomoxetine in a drug-abusing population. Drug Alcohol Depend 2008 May; 95(1–2): 140–6PubMed
97.
Buitelaar JK, Michelson D, Danckaerts M, et al. A randomized, double-blind study of continuation treatment for attention-deficit/hyperactivity disorder after 1 year. Biol Psychiatry 2007 Mar; 61(5): 694–9PubMed
98.
Wernicke JF, Adler L, Spencer T, et al. Changes in symptoms and adverse events after discontinuation of atomoxetine in children and adults with attention deficit/ hyperactivity disorder: a prospective, placebo-controlled assessment. J Clin Psychopharmacol 2004 Feb; 24(1): 30–5PubMed
99.
Spencer T, Heiligenstein JH, Biederman J, et al. Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry 2002 Dec; 63(12): 1140–7PubMed
100.
Michelson D, Faries D, Wernicke J, et al., Atomoxetine ADHD Study Group. Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study. Pediatrics 2001 Nov; 10(5): E83
101.
Michelson D, Allen AJ, Busner J, et al. Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatry 2002 Nov; 159(11): 1896–901PubMed
102.
Cheng JY, Chen RY, Ko JS, et al. Efficacy and safety of atomoxetine for attention-deficit/hyperactivity disorder in children and adolescents: meta-analysis and metaregression analysis. Psychopharmacology (Berl) 2007 Oct; 194(2): 197–209
103.
Kemner JE, Starr HL, Ciccone PE, et al. Outcomes of OROS® methylphenidate compared with atomoxetine in children with ADHD: a multicenter, randomized prospective study. Adv Ther 2005 Sep; 22(5): 498–512PubMed
104.
Wigal SB, McGough JJ, McCracken JT, et al. A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. J Atten Disord 2005 Aug; 9(1): 275–89PubMed
105.
Wang Y, Zheng Y, Du Y, et al. Atomoxetine versus methylphenidate in paediatric outpatients with attention deficit hyperactivity disorder: a randomized, double-blind comparison trial. Aust N Z J Psychiatry 2007 Mar; 41(3): 222–30PubMed
106.
Newcorn JH, Kratochvil CJ, Allen AJ, et al., Atomoxetine/Methylphenidate Comparative Study Group. Atomoxetine and osmotically released methylphenidate for the treatment of attention deficit hyperactivity disorder: acute comparison and differential response. Am J Psychiatry 2008 Jun; 165(6): 721–30PubMed
107.
Michelson D, Buitelaar JK, Danckaerts M, et al. Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study. J Am Acad Child Adolesc Psychiatry 2004 Jul; 43(7): 896–904PubMed
108.
Donnelly C, Bangs M, Trzepacz P, et al. Safety and tolerability of atomoxetine over 3 to 4 years in children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 2009 Feb; 48(2): 176–85PubMed
109.
Wilens TE, Newcorn JH, Kratochvil CJ, et al. Long-term atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder. J Pediatr 2006 Jul; 149(1): 112–9PubMed
110.
Kratochvil CJ, Wilens TE, Greenhill LL, et al. Effects of long-term atomoxetine treatment for young children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2006 Aug; 45(8): 919–27PubMed
111.
112.
Bangs ME, Tauscher-Wisniewski S, Polzer J, et al. Metaanalysis of suicide related behavior events in patients treated with atomoxetine. J Am Acad Child Adolesc Psychiatry 2008 Feb; 47(2): 209–183PubMed
113.
Atomoxetine ADHD and Comorbid MDD Study Group. Efficacy and safety of atomoxetine in adolescents with attention-deficit/hyperactivity disorder and major depression. J Child Adolesc Psychopharmacol 2007 Aug; 17(4): 407–20
114.
Spencer TJ, Sallee FR, Gilbert DL, et al. Atomoxetine treatment of ADHD in children with comorbid Tourette’s syndrome. J Atten Disord 2008 Jan; 11(4): 470–81PubMed
115.
Ledbetter M. Atomoxetine use associated with onset of a motor tic. J Child Adolesc Psychopharmacol 2005 Apr; 15(2): 331–3PubMed
116.
Párraga HC, Párraga KL, Harris DK, et al. Abdominal tics during atomoxetine treatment in a child with ADHD: evaluation and differential diagnosis. CNS Spectr 2008 Sep; 13(9): E1PubMed
117.
Párraga HC, Párraga MI, Harris DK. Tic exacerbation and precipitation during atomoxetine treatment in two children with attention-deficit hyperactivity disorder. Int J Psychiatry Med 2007; 37(4): 415–24PubMed
118.
Sears J, Patel NC. Development of tics in a thirteen-year-old male following atomoxetine use. CNS Spectr 2008 Apr; 13(4): 301–3PubMed
119.
Geller D, Donnelly C, Lopez F, et al. Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder. J Am Acad Child Adolesc Psychiatry 2007 Sep; 46(9): 1119–27PubMed
120.
Bangs ME, Hazell P, Danckaerts M, et al. Atomoxetine for the treatment of attention-deficit/hyperactivity disorder and oppositional defiant disorder. Pediatrics 2008 Feb; 121(2): E314–20PubMed
121.
Newcorn JH, Spencer TJ, Biederman J, et al. Atomoxetine treatment in children and adolescents with attention deficit/hyperactivity disorder and comorbid oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry 2005; 44(3): 240–8PubMed
122.
Biederman J, Spencer TJ, Newcorn JH, et al. Effect of comorbid symptoms of oppositional defiant disorder on responses to atomoxetine in children with ADHD: a meta-analysis of controlled clinical trial data. Psychopharmacology (Berl) 2007 Jan; 190(1): 31–41
123.
Hazell P, Zhang S, Wolańczyk T, et al. Comorbid oppositional defiant disorder and the risk of relapse during 9 months of atomoxetine treatment for attention-deficit/ hyperactivity disorder. Eur Child Adolesc Psychiatry 2006 Mar; 15(2): 105–10PubMed
124.
Ji XH, Ji JZ, Zhang H, et al. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology 2008 Aug; 33(9): 2263–71PubMed
125.
Levy F. Pharmacological and therapeutic directions in ADHD: specificity in the PFC. Behav Brain Funct 2008 Feb; 4: 12PubMed
126.
Wang M, Ramos BP, Paspalas CD, et al. Alpha 2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 2007 Apr; 129(2): 397–410PubMed
127.
Boellner SW, Pennick M, Fiske K, et al. Pharmacokinetics of a guanfacine extended-release formulation in children and adolescents with attention deficit-hyperactivity disorder. Pharmacotherapy 2007 Sep; 27(9): 1253–62PubMed
128.
Hunt RD, Arnsten AF, Asbell MD. An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1995 Jan; 34(1): 50–4PubMed
129.
Chappell PB, Riddle MA, Scahill L, et al. Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette’s syndrome: preliminary clinical experience. J Am Acad Child Adolesc Psychiatry 1995 Sep; 34(9): 1140–6PubMed
130.
Scahill L, Chappell PB, Kim YS, et al. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 2001 Jul; 158(7): 1067–74PubMed
131.
132.
Biederman J, Melmed RD, Patel A, et al., SPD503 Study Group. A randomized, double blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder. Pediatrics 2008 Jan; 121(1): E73–84PubMed
133.
Sallee F, McGough J, Wigal T, et al., SPD503 Study Group. Guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 2009 Feb; 48(2): 155–65PubMed
134.
Biederman J, Melmed RD, Patel A, et al. Long-term, open-label extension study of guanfaciine extended release in children and adolescents with ADHD. CNS Spectr 2008 Dec; 13(12): 1047–55PubMed
135.
Sallee FR, Lyne A, Wigal T, et al. Long-term safety and efficacy of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2009 Jun; 19(3): 215–26PubMed
136.
Choi Y, Novak JC, Hillier A, et al. The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol 2006 Dec; 19(4): 204–7PubMed
137.
The Tourette’s Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology 2002 Feb; 58: 527–36
138.
Palumbo DR, Sallee FR, Pelham WE, et al. Clonidine for attention-deficit/hyperactivity disorder: I. Efficacy and tolerability outcomes. J Am Acad Child Adolesc Psychiatry 2008 Feb; 47(2): 180–8PubMed
139.
Daviss WB, Patel NC, Robb AS. Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry 2008 Feb; 47(2): 189–98PubMed
140.
Nair V, Mahadevan S. Randomised controlled study-efficacy of clonidine versus carbamazepine in children with ADHD. J Trop Pediatr 2009 Apr; 55(2): 116–21PubMed
141.
142.
143.
144.
Connor DF, Fletcher KE, Swanson JM. A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1999 Dec; 38(12): 1551–9PubMed
145.
Chan E, Zhan C, Homer CJ. Health care use and costs for children with attention-deficit/hyperactivity disorder: national estimates from the medical expenditure panel survey. Arch Pediatr Adolesc Med 2002 May; 156(5): 504–11PubMed
146.
Schlander M. Impact of attention-deficit/hyperactivity disorder (ADHD) on prescription drug spending for children and adolescents: increasing relevance of health economic evidence. Child Adolesc Psychiatry Ment Health 2007 Nov; 1(1): E13
147.
Cottrell S, Tilden D, Robinson P, et al. A modeled economic evaluation comparing atomoxetine with stimulant therapy in the treatment of children with attention-deficit/ hyperactivity disorder in the United Kingdom. Value Health 2008 May–Jun; 11(3): 376–88PubMed
148.
Hong J, Dilla T, Arellano J. A modeled economic evaluation comparing atomoxetine with methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder in Spain. BMC Psychiatry 2009 Apr; 9: E15
149.
Rx product listing. In: Red book: pharmacy’s fundamental reference. 2009 ed. Montvale (NJ): Thompson Reuters, 2009: 173-816
150.
Steele M, Jensen PS, Quinn D, et al. Remission versus response as the goal of therapy in ADHD: a new standard for the field? Clin Ther 2006 Nov; 28(11): 1892–908PubMed
151.
Buitelaar JK, Wilens TE, Zhang S, et al. Comparison of symptomatic versus functional changes in children and adolescents with ADHD during randomized, double-blind treatment with psychostimulants, atomoxetine, or placebo. J Child Psychol Psychiatry 2008 Oct; 50(3): 335–42
152.
King S, Griffin S, Hodges Z, et al. A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. Health Technol Assess 2006 Jul; 10(23): 1–146
153.
Svanborg P, Thernlund G, Gustafsson PA, et al. Atomoxetine improves patient and family coping in attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in Swedish children and adolescents. Eur Child Adolesc Psychiatry. Epub 2009 May 23
154.
Varni JW, Burwinkle TM. The PedsQL as a patient-reported outcome in children and adolescents with attention-deficit/hyperactivity disorder: a population-based study. Health Qual Life Outcomes 2006 Apr; 4: 26PubMed
155.
Klassen AF, Miller A, Fine S. Health-related quality of life in children and adolescents who have a diagnosis of attention deficit/hyperactivity disorder. Pediatrics 2004; 114(5): E541–47PubMed
156.
Yang P, Hsu HY, Chiou SS, et al. Health-related quality of life in methylphenidate-treated children with attention-deficit-hyperactivity disorder: results from a Taiwanese sample. Aust N Z J Psychiatry 2007 Dec; 41(12): 998–1004PubMed
157.
Foster EM, Jensen PS, Schlander M, et al. Treatment for ADHD: Is more complex treatment cost-effective for more complex cases? Health Serv Res 2007 Feb; 42 (1 Pt 1): 165–82PubMed
158.
Schlander M. Long-acting medications for the hyperkinetic disorders: a note on cost-effectiveness. Eur Child Adolesc Psychiatry 2007 Oct; 16(7): 421–9PubMed
159.
Weiss MD, Gadow K, Wasdell MB. Effectiveness outcomes in attention-deficit hyperactivity disorder. J Clin Psychiatry 2006; 67 Suppl. 8: 38–45
160.
Metadata
Title
Attention-Deficit Hyperactivity Disorder
Recent Advances in Paediatric Pharmacotherapy
Authors
Diane E. May
Professor Christopher J. Kratochvil
Publication date
01-01-2010
Publisher
Springer International Publishing
Published in
Drugs / Issue 1/2010
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.2165/11530540-000000000-00000

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