Skip to main content
Top
Published in: Pediatric Drugs 5/2007

01-09-2007 | Current Opinion

Current Issues in Pediatric Medication Adherence

Author: Dr Doreen Matsui

Published in: Pediatric Drugs | Issue 5/2007

Login to get access

Abstract

With the recent emphasis on investigating the efficacy of medication in children, it is also important to assess what determines whether pediatric patients do or do not take their medication. In general, children are no better at adhering to drug therapy than older individuals. Dealing with medication nonadherence is essential given its association with a failure to achieve the desired treatment goal. In addition to the many factors that influence adherence in adults, there are some unique challenges faced in the pediatric age group including the role of family (and its dysfunction), the changes of adolescence, and the lack of appropriate drug formulations.
Intervention strategies to improve adherence include behavioral and educational strategies. Although there is no consensus as to what is the best approach to promote adherence with therapy, attention should be given to determining what barriers exist and trying to overcome them by involving children and their parents in the treatment planning process. If possible, the medication regimen, taking into account the frequency and timing of administration, should be tailored to the child and family’s lifestyle and daily routine. Consideration should be given to the palatability and formulations of medications prescribed for young children. The use of simplified regimens of better tasting medications and age-appropriate delivery mechanisms may enhance the ability of pediatric patients to adhere to their drug therapy.
Footnotes
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
Literature
2.
go back to reference Bonaccorso S. What information do patients need about medicines? Perspectives from the pharmaceutical industry. BMJ 2003; 327: 863–4PubMedCrossRef Bonaccorso S. What information do patients need about medicines? Perspectives from the pharmaceutical industry. BMJ 2003; 327: 863–4PubMedCrossRef
3.
go back to reference Winnick S, Lucas DO, Hartman AL, et al. How do you improve compliance? Pediatrics 2005; 115: e718–24PubMedCrossRef Winnick S, Lucas DO, Hartman AL, et al. How do you improve compliance? Pediatrics 2005; 115: e718–24PubMedCrossRef
4.
go back to reference Burkhart PV, Dunbar-Jacob J. Adherence research in the pediatric and adolescent populations: a decade in review. In: Hayman LL, Mahon MM, Turner JR, editors. Chronic illness in children: an evidence-based approach. New York: Springer Publishing Company, Inc., 2002: 199–229 Burkhart PV, Dunbar-Jacob J. Adherence research in the pediatric and adolescent populations: a decade in review. In: Hayman LL, Mahon MM, Turner JR, editors. Chronic illness in children: an evidence-based approach. New York: Springer Publishing Company, Inc., 2002: 199–229
5.
8.
go back to reference Ellis S, Shumaker S, Sieber W, et al. Adherence to pharmacological interventions: current trends and future directions. Control Clin Trials 2000; 21: 218S–25SPubMedCrossRef Ellis S, Shumaker S, Sieber W, et al. Adherence to pharmacological interventions: current trends and future directions. Control Clin Trials 2000; 21: 218S–25SPubMedCrossRef
9.
go back to reference Rudd P, Ahmed S, Zachary V, et al. Compliance with medication timing: implications from a medication trial for drug development and clinical practice. J Clin Res Pharmacoepidemiol 1992; 6: 15–27 Rudd P, Ahmed S, Zachary V, et al. Compliance with medication timing: implications from a medication trial for drug development and clinical practice. J Clin Res Pharmacoepidemiol 1992; 6: 15–27
10.
go back to reference Dusing R, Lottermoser K, Mengden T. Compliance with drug therapy: new answers to an old question. Nephrol Dial Transplant 2001; 16: 1317–21PubMedCrossRef Dusing R, Lottermoser K, Mengden T. Compliance with drug therapy: new answers to an old question. Nephrol Dial Transplant 2001; 16: 1317–21PubMedCrossRef
11.
go back to reference DiMatteo MR, Giordani PJ, Lepper HS, et al. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002; 40: 794–811PubMedCrossRef DiMatteo MR, Giordani PJ, Lepper HS, et al. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002; 40: 794–811PubMedCrossRef
12.
go back to reference Bauman LJ, Wright E, Leickly FE, et al. Relationship of adherence to pediatric asthma morbidity among inner-city children. Pediatrics 2002; 110: e6PubMedCrossRef Bauman LJ, Wright E, Leickly FE, et al. Relationship of adherence to pediatric asthma morbidity among inner-city children. Pediatrics 2002; 110: e6PubMedCrossRef
13.
go back to reference Ordonez GA, Phelan PD, Olinsky A, et al. Preventable factors in hospital admissions for asthma. Arch Dis Child 1998; 78: 143–7PubMedCrossRef Ordonez GA, Phelan PD, Olinsky A, et al. Preventable factors in hospital admissions for asthma. Arch Dis Child 1998; 78: 143–7PubMedCrossRef
14.
go back to reference Milgrom H, Bender B, Ackerson L, et al. Noncompliance and treatment failure in children with asthma. J Allergy Clin Immunol 1996; 98: 1051–7PubMedCrossRef Milgrom H, Bender B, Ackerson L, et al. Noncompliance and treatment failure in children with asthma. J Allergy Clin Immunol 1996; 98: 1051–7PubMedCrossRef
15.
go back to reference Stoloff SW. Improving adherence to asthma therapy: what physicians can do. Am Fam Physician 2000; 61(8): 2328, 2330, 2337PubMed Stoloff SW. Improving adherence to asthma therapy: what physicians can do. Am Fam Physician 2000; 61(8): 2328, 2330, 2337PubMed
16.
go back to reference Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004; 27: 1218–24PubMedCrossRef Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004; 27: 1218–24PubMedCrossRef
17.
go back to reference Festa RS, Tamaroff MH, Chasalow F, et al. Therapeutic adherence to oral medication regimens by adolescents with cancer: I. Laboratory assessment. J Pediatr 1992; 120: 807–11PubMedCrossRef Festa RS, Tamaroff MH, Chasalow F, et al. Therapeutic adherence to oral medication regimens by adolescents with cancer: I. Laboratory assessment. J Pediatr 1992; 120: 807–11PubMedCrossRef
18.
go back to reference de Oliveira BM, Viana MB, Zani CL, et al. Clinical and laboratory evaluation of compliance in acute lymphoblastic leukaemia. Arch Dis Child 2004; 89: 785–8PubMedCrossRef de Oliveira BM, Viana MB, Zani CL, et al. Clinical and laboratory evaluation of compliance in acute lymphoblastic leukaemia. Arch Dis Child 2004; 89: 785–8PubMedCrossRef
19.
go back to reference Lilleyman JS, Lennard L. Non-compliance with oral chemotherapy in childhood leukaemia. BMJ 1996; 313: 1219–20PubMedCrossRef Lilleyman JS, Lennard L. Non-compliance with oral chemotherapy in childhood leukaemia. BMJ 1996; 313: 1219–20PubMedCrossRef
20.
go back to reference Shaw RJ, Palmer L, Blasey C, et al. A typology of non-adherence in pediatric renal transplant recipients. Pediatr Transplant 2003; 7: 489–93PubMedCrossRef Shaw RJ, Palmer L, Blasey C, et al. A typology of non-adherence in pediatric renal transplant recipients. Pediatr Transplant 2003; 7: 489–93PubMedCrossRef
21.
go back to reference Meyers KEC, Weiland H, Thomson PD. Paediatric renal transplantation non-compliance. Pediatr Nephrol 1995; 9: 189–92PubMedCrossRef Meyers KEC, Weiland H, Thomson PD. Paediatric renal transplantation non-compliance. Pediatr Nephrol 1995; 9: 189–92PubMedCrossRef
22.
go back to reference Korsch BM, Fine RN, Negrete VF. Noncompliance in children with renal transplants. Pediatrics 1978; 61: 872–6PubMed Korsch BM, Fine RN, Negrete VF. Noncompliance in children with renal transplants. Pediatrics 1978; 61: 872–6PubMed
23.
go back to reference Shemesh E, Shneider BL, Savitzky JK, et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004; 113: 825–32PubMedCrossRef Shemesh E, Shneider BL, Savitzky JK, et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004; 113: 825–32PubMedCrossRef
24.
go back to reference Ringewald JM, Gidding SS, Crawford SE, et al. Nonadherence is associated with late rejection in pediatric heart transplant recipients. J Pediatr 2001; 139: 75–8PubMedCrossRef Ringewald JM, Gidding SS, Crawford SE, et al. Nonadherence is associated with late rejection in pediatric heart transplant recipients. J Pediatr 2001; 139: 75–8PubMedCrossRef
25.
go back to reference Gibbs DM, Goodall RL, Giacomet V, et al. Adherence to prescribed antiretroviral therapy in human immunodeficiency virus-infected children in the PENTA 5 trial. Pediatr Infect Dis J 2003; 22: 56–62CrossRef Gibbs DM, Goodall RL, Giacomet V, et al. Adherence to prescribed antiretroviral therapy in human immunodeficiency virus-infected children in the PENTA 5 trial. Pediatr Infect Dis J 2003; 22: 56–62CrossRef
26.
go back to reference Farley J, Hines S, Musk A, et al. Assessment of adherence to antiviral therapy in HIV-infected children using the medication event monitoring system, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. J Acquir Immune Defic Syndr 2003; 33: 211–8PubMedCrossRef Farley J, Hines S, Musk A, et al. Assessment of adherence to antiviral therapy in HIV-infected children using the medication event monitoring system, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. J Acquir Immune Defic Syndr 2003; 33: 211–8PubMedCrossRef
27.
go back to reference Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 2006; 333(7557): 15PubMedCrossRef Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 2006; 333(7557): 15PubMedCrossRef
28.
go back to reference Easton LK, Parsons BJ, Starr M, et al. The incidence of drug-related problems as a cause of hospital admissions in children. Med J Aust 1998; 169: 356–9PubMed Easton LK, Parsons BJ, Starr M, et al. The incidence of drug-related problems as a cause of hospital admissions in children. Med J Aust 1998; 169: 356–9PubMed
29.
go back to reference Quittner AL, Espelage DL, Levers-Landis C, et al. Measuring adherence to medical treatments in childhood chronic illness: considering multiple methods and sources of information. J Clin Psychol Med Settings 2000; 7: 41–54CrossRef Quittner AL, Espelage DL, Levers-Landis C, et al. Measuring adherence to medical treatments in childhood chronic illness: considering multiple methods and sources of information. J Clin Psychol Med Settings 2000; 7: 41–54CrossRef
30.
go back to reference Matsui DM. Drug compliance in pediatrics clinical and research issues. Pediatr Clin North Am 1997; 44: 1–14PubMedCrossRef Matsui DM. Drug compliance in pediatrics clinical and research issues. Pediatr Clin North Am 1997; 44: 1–14PubMedCrossRef
31.
go back to reference Kruse W. Patient compliance with drug treatment: new perspectives on an old problem. Clin Investig 1992; 70: 163–6PubMedCrossRef Kruse W. Patient compliance with drug treatment: new perspectives on an old problem. Clin Investig 1992; 70: 163–6PubMedCrossRef
32.
go back to reference Feinstein AR. On white-coat effects and the electronic monitoring of compliance. Arch Intern Med 1990; 150: 377–8CrossRef Feinstein AR. On white-coat effects and the electronic monitoring of compliance. Arch Intern Med 1990; 150: 377–8CrossRef
33.
go back to reference Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273–7PubMedCrossRef Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273–7PubMedCrossRef
34.
go back to reference Berkovitch M, Papadouris D, Shaw D, et al. Trying to improve compliance with prophylactic penicillin therapy in children with sickle cell disease. Br J Clin Pharamcol 1998; 45: 605–7CrossRef Berkovitch M, Papadouris D, Shaw D, et al. Trying to improve compliance with prophylactic penicillin therapy in children with sickle cell disease. Br J Clin Pharamcol 1998; 45: 605–7CrossRef
35.
go back to reference Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23: 1296–310PubMedCrossRef Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23: 1296–310PubMedCrossRef
36.
go back to reference Richter A, Anton SF, Koch P, et al. The impact of reducing dose frequency on health outcomes. Clin Ther 2003; 25: 2307–35PubMedCrossRef Richter A, Anton SF, Koch P, et al. The impact of reducing dose frequency on health outcomes. Clin Ther 2003; 25: 2307–35PubMedCrossRef
37.
go back to reference Mattar ME, Markello J, Yaffe SJ. Pharmaceutic factors affecting pediatric compliance. Pediatrics 1975; 55: 101–8PubMed Mattar ME, Markello J, Yaffe SJ. Pharmaceutic factors affecting pediatric compliance. Pediatrics 1975; 55: 101–8PubMed
38.
go back to reference Mattar ME, Markello J, Yaffe SJ. Inadequacies in the pharmacologic management of ambulatory children. J Pediatr 1975; 87: 137–41PubMedCrossRef Mattar ME, Markello J, Yaffe SJ. Inadequacies in the pharmacologic management of ambulatory children. J Pediatr 1975; 87: 137–41PubMedCrossRef
39.
go back to reference Thatcher Shope J. Medication compliance. Pediatr Clin North Am 1981; 28: 5–21 Thatcher Shope J. Medication compliance. Pediatr Clin North Am 1981; 28: 5–21
40.
go back to reference Bender BG, Bender SE. Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires. Immunol Allergy Clin North Am 2005; 25: 107–30PubMedCrossRef Bender BG, Bender SE. Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires. Immunol Allergy Clin North Am 2005; 25: 107–30PubMedCrossRef
41.
go back to reference Gau SSF, Shen H, Chou M, et al. Determinants of adherence to methylphenidate and the impact of poor adherence on maternal and family measures. J Child Adolesc Psychopharmacol 2006; 16: 286–97PubMedCrossRef Gau SSF, Shen H, Chou M, et al. Determinants of adherence to methylphenidate and the impact of poor adherence on maternal and family measures. J Child Adolesc Psychopharmacol 2006; 16: 286–97PubMedCrossRef
42.
go back to reference Mackner LM, Crandall WV. Oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2005; 11: 1006–12PubMedCrossRef Mackner LM, Crandall WV. Oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2005; 11: 1006–12PubMedCrossRef
43.
go back to reference Staples B, Bravender T. Drug compliance in adolescents assessing and managing modifiable risk factors. Pediatr Drugs 2002; 4: 503–13 Staples B, Bravender T. Drug compliance in adolescents assessing and managing modifiable risk factors. Pediatr Drugs 2002; 4: 503–13
44.
go back to reference Litt IF, Cuskey WR. Compliance with medical regimens during adolescence. Pediatr Clin North Am 1980; 27: 3–15PubMed Litt IF, Cuskey WR. Compliance with medical regimens during adolescence. Pediatr Clin North Am 1980; 27: 3–15PubMed
45.
go back to reference Morris AD, Boyle DIR, McMahon AD, et al. Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. Lancet 1997; 350: 1505–10PubMedCrossRef Morris AD, Boyle DIR, McMahon AD, et al. Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. Lancet 1997; 350: 1505–10PubMedCrossRef
46.
go back to reference Lancaster D, Lennard L, Lilleyman JS. Profile of non-compliance in lymphoblastic leukaemia. Arch Dis Child 1997; 76: 365–6PubMedCrossRef Lancaster D, Lennard L, Lilleyman JS. Profile of non-compliance in lymphoblastic leukaemia. Arch Dis Child 1997; 76: 365–6PubMedCrossRef
47.
go back to reference Tebbi CK, Cummings KM, Zevon MA, et al. Compliance of pediatric and adolescent cancer patients. Cancer 1986; 58: 1179–84PubMedCrossRef Tebbi CK, Cummings KM, Zevon MA, et al. Compliance of pediatric and adolescent cancer patients. Cancer 1986; 58: 1179–84PubMedCrossRef
48.
go back to reference Smith BA, Shuchman M. Problem of nonadherence in chronically ill adolescents: strategies for assessment and intervention. Curr Opin Pediatr 2005; 17: 613–8PubMedCrossRef Smith BA, Shuchman M. Problem of nonadherence in chronically ill adolescents: strategies for assessment and intervention. Curr Opin Pediatr 2005; 17: 613–8PubMedCrossRef
49.
go back to reference Rosina R, Crisp J, Steinbeck K. Treatment adherence of youth and young adults with and without a chronic illness. Nurs Health Sci 2003; 5: 139–47PubMedCrossRef Rosina R, Crisp J, Steinbeck K. Treatment adherence of youth and young adults with and without a chronic illness. Nurs Health Sci 2003; 5: 139–47PubMedCrossRef
50.
go back to reference Feinstein S, Keich R, Becker-Cohen R, et al. Is noncompliance among adolescent renal transplant recipients inevitable? Pediatrics 2005; 115: 969–73PubMedCrossRef Feinstein S, Keich R, Becker-Cohen R, et al. Is noncompliance among adolescent renal transplant recipients inevitable? Pediatrics 2005; 115: 969–73PubMedCrossRef
51.
go back to reference Ramgoolam A, Steele R. Formulations of antibiotics for children in primary care effects on compliance and efficacy. Pediatr Drugs 2002; 4: 323–33 Ramgoolam A, Steele R. Formulations of antibiotics for children in primary care effects on compliance and efficacy. Pediatr Drugs 2002; 4: 323–33
52.
go back to reference Goode M, McMaugh A, Crisp J, et al. Adherence issues in children and adolescents receiving highly active antiretroviral therapy. AIDS Care 2003; 15: 403–8PubMedCrossRef Goode M, McMaugh A, Crisp J, et al. Adherence issues in children and adolescents receiving highly active antiretroviral therapy. AIDS Care 2003; 15: 403–8PubMedCrossRef
53.
go back to reference Tucker CM, Fennell RS, Pederson T, et al. Associations with medication adherence among ethnically different pediatric patients with renal transplants. Pediatr Nephrol 2002; 17: 251–6PubMedCrossRef Tucker CM, Fennell RS, Pederson T, et al. Associations with medication adherence among ethnically different pediatric patients with renal transplants. Pediatr Nephrol 2002; 17: 251–6PubMedCrossRef
54.
go back to reference Dawson A, Newell R. The extent of parental compliance with timing of administration of their children’s antibiotics. J Adv Nurs 1994; 20: 483–90PubMedCrossRef Dawson A, Newell R. The extent of parental compliance with timing of administration of their children’s antibiotics. J Adv Nurs 1994; 20: 483–90PubMedCrossRef
55.
go back to reference Gibson NA, Ferguson AE, Aitchison TC, et al. Compliance with inhaled asthma medication in preschool children. Thorax 1995; 50: 1274–9PubMedCrossRef Gibson NA, Ferguson AE, Aitchison TC, et al. Compliance with inhaled asthma medication in preschool children. Thorax 1995; 50: 1274–9PubMedCrossRef
56.
go back to reference Lau RCW, Matsui D, Greenberg M, et al. Electronic measurement of compliance with mercaptopurine in pediatric patients with acute lymphoblastic leukemia. Med Pediatr Oncol 1998; 30: 85–90PubMedCrossRef Lau RCW, Matsui D, Greenberg M, et al. Electronic measurement of compliance with mercaptopurine in pediatric patients with acute lymphoblastic leukemia. Med Pediatr Oncol 1998; 30: 85–90PubMedCrossRef
57.
go back to reference Blowey DL, Herbert D, Arbus GS, et al. Compliance with cyclosporine in adolescent renal transplant recipients. Pediatr Nephrol 1997; 11: 547–51PubMedCrossRef Blowey DL, Herbert D, Arbus GS, et al. Compliance with cyclosporine in adolescent renal transplant recipients. Pediatr Nephrol 1997; 11: 547–51PubMedCrossRef
58.
go back to reference Jonasson G, Carlsen K, Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch Dis Child 2000; 83: 330–3PubMedCrossRef Jonasson G, Carlsen K, Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch Dis Child 2000; 83: 330–3PubMedCrossRef
59.
go back to reference Moncica I, Oh PI, ul Qamar I, et al. A crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension. Arch Dis Child 1995; 73: 154–6PubMedCrossRef Moncica I, Oh PI, ul Qamar I, et al. A crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension. Arch Dis Child 1995; 73: 154–6PubMedCrossRef
60.
go back to reference MacDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions scientific review. JAMA 2002; 288: 2868–79CrossRef MacDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions scientific review. JAMA 2002; 288: 2868–79CrossRef
61.
go back to reference Costello I, Wong ICK, Nunn AJ. A literature review to identify interventions to improve the use of medicines in children. Child Care Health Dev 2004; 30: 647–65PubMedCrossRef Costello I, Wong ICK, Nunn AJ. A literature review to identify interventions to improve the use of medicines in children. Child Care Health Dev 2004; 30: 647–65PubMedCrossRef
62.
63.
go back to reference DiMatteo MR. The role of effective communication with children and their families in fostering adherence to pediatric regimens. Patient Educ Couns 2004; 55: 339–44PubMedCrossRef DiMatteo MR. The role of effective communication with children and their families in fostering adherence to pediatric regimens. Patient Educ Couns 2004; 55: 339–44PubMedCrossRef
64.
go back to reference Bender BG. Overcoming barriers to nonadherence in asthma treatment. J Allergy Clin Immunol 2002; 109: S554–9PubMedCrossRef Bender BG. Overcoming barriers to nonadherence in asthma treatment. J Allergy Clin Immunol 2002; 109: S554–9PubMedCrossRef
65.
go back to reference McCrindle BW, O’Neill MB, Cullen-Dean G, et al. Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: a randomized, crossover trial. J Pediatr 1997; 130: 266–73PubMedCrossRef McCrindle BW, O’Neill MB, Cullen-Dean G, et al. Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: a randomized, crossover trial. J Pediatr 1997; 130: 266–73PubMedCrossRef
66.
68.
go back to reference Anbar RD. You don’t like the taste of your medication? So change the taste! Clin Pediatr 2002; 41: 197–8CrossRef Anbar RD. You don’t like the taste of your medication? So change the taste! Clin Pediatr 2002; 41: 197–8CrossRef
69.
go back to reference Sawyer SM, Aroni RA. Sticky issue of adherence. J Pediatr Child Health 2003; 39: 2–5CrossRef Sawyer SM, Aroni RA. Sticky issue of adherence. J Pediatr Child Health 2003; 39: 2–5CrossRef
70.
go back to reference Schroeder K, Fahey T, Ebrahim S. How can we improve adherence to blood pressure-lowering medication in ambulatory care? Systematic review of randomized controlled trials. Arch Intern Med 2004; 164: 722–32PubMedCrossRef Schroeder K, Fahey T, Ebrahim S. How can we improve adherence to blood pressure-lowering medication in ambulatory care? Systematic review of randomized controlled trials. Arch Intern Med 2004; 164: 722–32PubMedCrossRef
71.
go back to reference Swanson J. Compliance with stimulants for attention-deficit/hyperactivity disorder issues and approaches for improvement. CNS Drugs 2003; 17: 117–31PubMedCrossRef Swanson J. Compliance with stimulants for attention-deficit/hyperactivity disorder issues and approaches for improvement. CNS Drugs 2003; 17: 117–31PubMedCrossRef
72.
go back to reference Boulet LP. Once-daily inhaled corticosteroids for the treatment of asthma. Curr Opin Pulm Med 2003; 10: 15–21CrossRef Boulet LP. Once-daily inhaled corticosteroids for the treatment of asthma. Curr Opin Pulm Med 2003; 10: 15–21CrossRef
73.
go back to reference Boissel J, Nony P. Using pharmacokinetic-pharmacodynamic relationships to predict the effect of poor compliance. Clin Pharmacokinet 2002; 41: 1–6PubMedCrossRef Boissel J, Nony P. Using pharmacokinetic-pharmacodynamic relationships to predict the effect of poor compliance. Clin Pharmacokinet 2002; 41: 1–6PubMedCrossRef
74.
go back to reference Urquhart J. Patient non-compliance with drug regimens: measurement, clinic correlates, economic impact. Eur Heart J 1996; 17Suppl. A: 8–15PubMedCrossRef Urquhart J. Patient non-compliance with drug regimens: measurement, clinic correlates, economic impact. Eur Heart J 1996; 17Suppl. A: 8–15PubMedCrossRef
Metadata
Title
Current Issues in Pediatric Medication Adherence
Author
Dr Doreen Matsui
Publication date
01-09-2007
Publisher
Springer International Publishing
Published in
Pediatric Drugs / Issue 5/2007
Print ISSN: 1174-5878
Electronic ISSN: 1179-2019
DOI
https://doi.org/10.2165/00148581-200709050-00001

Other articles of this Issue 5/2007

Pediatric Drugs 5/2007 Go to the issue

Adis Drug Evaluation

Risperidone