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Drugs in R&D
Published in: Drugs in R&D 5/2008

01-09-2008 | Original Research Article

No Relationship between Plasma Desacyl-Ghrelin Levels and Rabeprazole-Related Delay in Gastric Emptying

Controlled Study in Healthy Volunteers

Authors: Dr Takatsugu Yamamoto, Masaki Sanaka, Hajime Anjiki, Kengo Hattori, Taro Ishii, Yasushi Kuyama

Published in: Drugs in R&D | Issue 5/2008

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Abstract

Background and objective: Recent studies have indicated that rabeprazole, a proton pump inhibitor, delays gastric emptying. However, the mechanism of action remains unclear. We conducted this study to clarify whether desacylghrelin (the inactive form of the endogenous growth hormone secretagogue receptor ghrelin) is involved in rabeprazole-induced changes in gastric motor function.
Methods: Twelve healthy males underwent 13C-acetate breath tests to evaluate gastric emptying of a liquid meal twice after administration of rabeprazole 20 mg/day for 3 days or no medication (control). Gastric emptying was evaluated by two parameters: half-emptying time and time to peak 13CO2 excretion. Plasma desacyl-ghrelin levels were measured in blood samples collected at three time points: immediately pre-test and 1 and 2 hours after ingestion of the test meal.
Results: Rabeprazole significantly delayed gastric emptying of the liquid meal. However, plasma desacyl-ghrelin levels after ingestion of the liquid meal showed little difference before or after rabeprazole administration.
Conclusion: The results indicate that desacyl-ghrelin was not associated with changes in gastric emptying caused by rabeprazole.
Footnotes
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
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Metadata
Title
No Relationship between Plasma Desacyl-Ghrelin Levels and Rabeprazole-Related Delay in Gastric Emptying
Controlled Study in Healthy Volunteers
Authors
Dr Takatsugu Yamamoto
Masaki Sanaka
Hajime Anjiki
Kengo Hattori
Taro Ishii
Yasushi Kuyama
Publication date
01-09-2008
Publisher
Springer International Publishing
Published in
Drugs in R&D / Issue 5/2008
Print ISSN: 1174-5886
Electronic ISSN: 1179-6901
DOI
https://doi.org/10.2165/00126839-200809050-00005

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