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Published in: CNS Drugs 5/2004

01-04-2004 | Therapy In Practice

Management of Insomnia in Patients with Chronic Pain Conditions

Authors: Prof. Frederic Stiefel, Daniele Stagno

Published in: CNS Drugs | Issue 5/2004

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Abstract

The management of insomnia in patients experiencing chronic pain requires careful evaluation, good diagnostic skills, familiarity with cognitive-behavioural interventions and a sound knowledge of pharmacological treatments. Sleep disorders are characterised by a circular interrelationship with chronic pain such that pain leads to sleep disorders and sleep disorders increase the perception of pain. Sleep disorders in individuals with chronic pain remain under-reported, under-diagnosed and under-treated, which may lead — together with the individual’s emotional, cognitive and behavioural maladaptive responses — to the frequent development of chronic sleep disorders. The moderately positive relationship between pain severity and sleep complaints, and the specificity of pain-related arousal and mediating variables such as depression, illustrate that insomnia in relation to chronic pain is multifaceted and poorly understood. This may explain the limited success of the available treatments.
This article discusses the evaluation of patients with chronic pain and insomnia and the available pharmacological and nonpharmacological interventions to manage the sleep disorder. Non-pharmacological interventions should not be considered as single interventions, but in association with one another. Some non-pharmacological interventions especially the cognitive and behavioural approaches, can be easily implemented in general practice (e.g. stimulus control, sleep restriction, imagery training and progressive muscle relaxation). Hypnotics are routinely prescribed in the medically ill, regardless of their adverse effects; however, their long-term efficacy is not supported by robust evidence. Antidepressants provide an interesting alternative to hypnotics, since they can improve pain perception as well as sleep disorders in selected patients. Sedative antipsychotics can be considered for sleep disturbances in those patients exhibiting psychotic features, or for those with contraindications to benzodiazepines. Low doses of sedative antipsychotics may improve chronic insomnia in the elderly. However, no intervention is likely to be effective unless a good physician-patient relationship is developed.
Literature
1.
go back to reference Bixler EO, Kales A, Soldatos CR, et al. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry 1979; 136(10): 1257–62PubMed Bixler EO, Kales A, Soldatos CR, et al. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry 1979; 136(10): 1257–62PubMed
2.
go back to reference International classification of sleep disorders. In: American Sleep Disorders Association, editor. Diagnostic and coding manual. Rochester (MN): Am Sleep Disorders Association, 1997 International classification of sleep disorders. In: American Sleep Disorders Association, editor. Diagnostic and coding manual. Rochester (MN): Am Sleep Disorders Association, 1997
3.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: AmericanPsychiatric Association, 2000 American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: AmericanPsychiatric Association, 2000
4.
go back to reference Sateia MJ, Doghramji K, Hauri PJ, et al. Evaluation of chronic insomnia: an American Academy of Sleep Medicine review. Sleep 2000; 23(2): 243–308PubMed Sateia MJ, Doghramji K, Hauri PJ, et al. Evaluation of chronic insomnia: an American Academy of Sleep Medicine review. Sleep 2000; 23(2): 243–308PubMed
5.
go back to reference Holmgren A, Wise M, Boukoms A. Pain management. In: Wise M, Rundell RJ, editors. The American psychiatric publishing textbook of consultation-liaison psychiatry. Washington, DC: American Psychiatric Publishing Textbook, 2002: 989–1011 Holmgren A, Wise M, Boukoms A. Pain management. In: Wise M, Rundell RJ, editors. The American psychiatric publishing textbook of consultation-liaison psychiatry. Washington, DC: American Psychiatric Publishing Textbook, 2002: 989–1011
7.
go back to reference Lamberg L. Chronic pain linked with poor sleep; exploration of causes and treatment. JAMA 1999; 281(8): 691–2PubMedCrossRef Lamberg L. Chronic pain linked with poor sleep; exploration of causes and treatment. JAMA 1999; 281(8): 691–2PubMedCrossRef
8.
go back to reference Ancoli-Israel S. Epidemiology of sleep disorders. Clin Geriatr Med 1989; 5(2): 347–62PubMed Ancoli-Israel S. Epidemiology of sleep disorders. Clin Geriatr Med 1989; 5(2): 347–62PubMed
9.
go back to reference National Sleep Foundation. Sleep in America: a national surveyof US adults. Princeton (NJ): The Gallup Organizations, 1991 National Sleep Foundation. Sleep in America: a national surveyof US adults. Princeton (NJ): The Gallup Organizations, 1991
10.
11.
go back to reference Atkinson JH, Slater MA, Grant I, et al. Depressed mood in chronic low back pain: relationship with stressful life events. Pain 1988; 35(1): 47–55PubMedCrossRef Atkinson JH, Slater MA, Grant I, et al. Depressed mood in chronic low back pain: relationship with stressful life events. Pain 1988; 35(1): 47–55PubMedCrossRef
12.
go back to reference Pilowski I, Townley M. Sleep disturbance in pain clinic patients. Pain 1985; 23(1): 27–33CrossRef Pilowski I, Townley M. Sleep disturbance in pain clinic patients. Pain 1985; 23(1): 27–33CrossRef
13.
go back to reference Everitt DE, Avorn J, Baker MW. Clinical decision-making in the evaluation and treatment of insomnia. Am J Med 1990; 89(3): 357–62PubMedCrossRef Everitt DE, Avorn J, Baker MW. Clinical decision-making in the evaluation and treatment of insomnia. Am J Med 1990; 89(3): 357–62PubMedCrossRef
14.
go back to reference Healey ES, Kales A, Monroe LJ, et al. Onset of insomnia: role of life-stress events. Psychosom Med 1981; 43(5): 439–51PubMed Healey ES, Kales A, Monroe LJ, et al. Onset of insomnia: role of life-stress events. Psychosom Med 1981; 43(5): 439–51PubMed
15.
go back to reference Edinger JD, Stout AL, Hoelscher TJ. Cluster analysis of insomniacs’ MMPI profiles: relation of subtypes to sleep history and treatment outcome. Psychosom Med 1988; 50(1): 77–87PubMed Edinger JD, Stout AL, Hoelscher TJ. Cluster analysis of insomniacs’ MMPI profiles: relation of subtypes to sleep history and treatment outcome. Psychosom Med 1988; 50(1): 77–87PubMed
16.
go back to reference Lawrence CC, Gilbert CJ, Peters WP. Evaluation of symptom distress in a bone marrow transplant outpatient environment. Ann Pharmacother 1996; 30(9): 941–5PubMed Lawrence CC, Gilbert CJ, Peters WP. Evaluation of symptom distress in a bone marrow transplant outpatient environment. Ann Pharmacother 1996; 30(9): 941–5PubMed
17.
go back to reference Smith MT, Perlis ML, Carmody TP, et al. Presleep cognitions in patients with insomnia secondary to chronic pain. J Behav Med 2001; 24(1): 93–114PubMedCrossRef Smith MT, Perlis ML, Carmody TP, et al. Presleep cognitions in patients with insomnia secondary to chronic pain. J Behav Med 2001; 24(1): 93–114PubMedCrossRef
18.
go back to reference Wilson KG, Eriksson MY, D’Eon JL, et al. Major depression and insomnia in chronic pain. Clin J Pain 2002; 18(2): 77–83PubMedCrossRef Wilson KG, Eriksson MY, D’Eon JL, et al. Major depression and insomnia in chronic pain. Clin J Pain 2002; 18(2): 77–83PubMedCrossRef
19.
go back to reference Smith MT, Perlis ML, Smith MS, et al. Sleep quality and presleep arousal in chronic pain. J Behav Med 2000; 23(1): 1–13PubMedCrossRef Smith MT, Perlis ML, Smith MS, et al. Sleep quality and presleep arousal in chronic pain. J Behav Med 2000; 23(1): 1–13PubMedCrossRef
20.
go back to reference Currie SR, Wilson KG, Curran D. Clinical significance and predictors of treatment response to cognitive-behavior therapy for insomnia secondary to chronic pain. J Behav Med 2002; 25(2): 135–53PubMedCrossRef Currie SR, Wilson KG, Curran D. Clinical significance and predictors of treatment response to cognitive-behavior therapy for insomnia secondary to chronic pain. J Behav Med 2002; 25(2): 135–53PubMedCrossRef
21.
go back to reference Currie SR, Wilson KG, Pontefract AJ, et al. Cognitive-behavioral treatment of insomnia secondary to chronic pain. J Consult Clin Psychol 2000; 68(3): 407–16PubMedCrossRef Currie SR, Wilson KG, Pontefract AJ, et al. Cognitive-behavioral treatment of insomnia secondary to chronic pain. J Consult Clin Psychol 2000; 68(3): 407–16PubMedCrossRef
22.
go back to reference Smith MT, Perlis ML, Haythornwaite JA. Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensity. Clin J Pain 2004; 20(2): 111–8PubMedCrossRef Smith MT, Perlis ML, Haythornwaite JA. Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensity. Clin J Pain 2004; 20(2): 111–8PubMedCrossRef
23.
go back to reference Schneider-Helmert D, Whitehouse I, Kumar A, et al. Insomnia and alpha sleep in chronic non-organic pain as compared to primary insomnia. Neuropsychobiology 2001; 43(1): 54–8PubMedCrossRef Schneider-Helmert D, Whitehouse I, Kumar A, et al. Insomnia and alpha sleep in chronic non-organic pain as compared to primary insomnia. Neuropsychobiology 2001; 43(1): 54–8PubMedCrossRef
24.
go back to reference Stroud MW, Thorn BE, Jensen MP, et al. The relation between pain beliefs, negative thoughts, and psychological functioning in chronic pain. Pain 2000; 84(2–3): 347–52PubMedCrossRef Stroud MW, Thorn BE, Jensen MP, et al. The relation between pain beliefs, negative thoughts, and psychological functioning in chronic pain. Pain 2000; 84(2–3): 347–52PubMedCrossRef
25.
go back to reference Wittig RM, Zorick FJ, Blumer D, et al. Disturbed sleep in patients complaining of chronic pain. J Nerv Ment Dis 1982; 170(7): 429–31PubMedCrossRef Wittig RM, Zorick FJ, Blumer D, et al. Disturbed sleep in patients complaining of chronic pain. J Nerv Ment Dis 1982; 170(7): 429–31PubMedCrossRef
26.
go back to reference Nicassio PM, Wallston KA. Longitudinal relationships among pain, sleep problems, and depression in rheumatoid arthritis. J Abnorm Psychol 1992; 101(3): 514–20PubMedCrossRef Nicassio PM, Wallston KA. Longitudinal relationships among pain, sleep problems, and depression in rheumatoid arthritis. J Abnorm Psychol 1992; 101(3): 514–20PubMedCrossRef
27.
go back to reference Savar K, Arikan M, Yontem T. Sleep quality in chronic pain patients. Can J Psychiatry 2002; 47(9): 844–8 Savar K, Arikan M, Yontem T. Sleep quality in chronic pain patients. Can J Psychiatry 2002; 47(9): 844–8
28.
go back to reference McCracken LM, Iverson GL. Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Res Manag 2002; 7(2): 75–9PubMed McCracken LM, Iverson GL. Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Res Manag 2002; 7(2): 75–9PubMed
29.
go back to reference Simms RW. Field guide to soft tissue pain: diagnosis and management. Philadelphia: Lippincott Williams & Wilkins, 2001 Simms RW. Field guide to soft tissue pain: diagnosis and management. Philadelphia: Lippincott Williams & Wilkins, 2001
31.
go back to reference Moldofsky H. Fibromyalgia, sleep disorder and chronic fatigue syndrome. Ciba Found Symp 1993; 173: 262–71PubMed Moldofsky H. Fibromyalgia, sleep disorder and chronic fatigue syndrome. Ciba Found Symp 1993; 173: 262–71PubMed
32.
go back to reference Parker AJ, Wessely S, Cleare AJ. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med 2001; 31(8): 1331–45PubMedCrossRef Parker AJ, Wessely S, Cleare AJ. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med 2001; 31(8): 1331–45PubMedCrossRef
33.
go back to reference Pollmacher T, Mullington J, Korth C, et al. Influence of host defense activation on sleep in humans. Adv Neuroimmunol 1995; 5(2): 155–69PubMedCrossRef Pollmacher T, Mullington J, Korth C, et al. Influence of host defense activation on sleep in humans. Adv Neuroimmunol 1995; 5(2): 155–69PubMedCrossRef
34.
go back to reference Smith GR. The epidemiology and treatment of depression when it coexists with somatoform disorders, somatization, or pain. Gen Hosp Psychiatry 1992; 14(4): 265–72PubMedCrossRef Smith GR. The epidemiology and treatment of depression when it coexists with somatoform disorders, somatization, or pain. Gen Hosp Psychiatry 1992; 14(4): 265–72PubMedCrossRef
35.
go back to reference Haythornthwaite JA, Sieber WJ, Kerns RD. Depression and the chronic pain experience. Pain 1991; 46(2): 177–84PubMedCrossRef Haythornthwaite JA, Sieber WJ, Kerns RD. Depression and the chronic pain experience. Pain 1991; 46(2): 177–84PubMedCrossRef
36.
go back to reference Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain 1998; 14(4): 311–4PubMedCrossRef Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain 1998; 14(4): 311–4PubMedCrossRef
37.
go back to reference Gamsa A. Is emotional disturbance a precipitator or a consequence of chronic pain? Pain 1990; 42(2): 183–95PubMedCrossRef Gamsa A. Is emotional disturbance a precipitator or a consequence of chronic pain? Pain 1990; 42(2): 183–95PubMedCrossRef
38.
go back to reference Wilson KG, Watson ST, Currie SR. Daily diary and ambulatory activity monitoring of sleep in patients with insomnia associated with chronic musculoskeletal pain. Pain 1998; 75(1): 75–84PubMedCrossRef Wilson KG, Watson ST, Currie SR. Daily diary and ambulatory activity monitoring of sleep in patients with insomnia associated with chronic musculoskeletal pain. Pain 1998; 75(1): 75–84PubMedCrossRef
39.
go back to reference Cochinov HM, Breitbart W, editors. Handbook of psychiatry in palliative medecine. New York: Oxford University Press, 2000 Cochinov HM, Breitbart W, editors. Handbook of psychiatry in palliative medecine. New York: Oxford University Press, 2000
40.
41.
go back to reference Meagher DJ, O’Hanlon D, O’Mahony E, et al. Relationship between symptoms and motoric subtype of delirium. J Neuropsychiatry Clin Neurosci 2000; 12(1): 51–6PubMed Meagher DJ, O’Hanlon D, O’Mahony E, et al. Relationship between symptoms and motoric subtype of delirium. J Neuropsychiatry Clin Neurosci 2000; 12(1): 51–6PubMed
42.
go back to reference Landis CA, Robinson CR, Helms C, et al. Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. Brain Res 1989; 488(1–2): 195–201PubMedCrossRef Landis CA, Robinson CR, Helms C, et al. Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model. Brain Res 1989; 488(1–2): 195–201PubMedCrossRef
43.
go back to reference Stiefel FC, Breitbart WS, Holland JC. Corticosteroids in cancer: neuropsychiatric complications. Cancer Invest 1989; 7(5): 479–91PubMedCrossRef Stiefel FC, Breitbart WS, Holland JC. Corticosteroids in cancer: neuropsychiatric complications. Cancer Invest 1989; 7(5): 479–91PubMedCrossRef
44.
go back to reference Reite M, Buysse D, Reynolds C, et al. The use of polysomnography in the evaluation of insomnia. Sleep 1995; 18(1): 58–70PubMed Reite M, Buysse D, Reynolds C, et al. The use of polysomnography in the evaluation of insomnia. Sleep 1995; 18(1): 58–70PubMed
45.
go back to reference Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis ofbenzodiazepine use in the treatment of insomnia. CMAJ 2000; 162(2): 225–38PubMed Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis ofbenzodiazepine use in the treatment of insomnia. CMAJ 2000; 162(2): 225–38PubMed
46.
go back to reference Zammit GK, Weiner G, Damato N, et al. Quality of life in people with insomnia. Sleep 1999; 22Suppl. 2: s379–85PubMed Zammit GK, Weiner G, Damato N, et al. Quality of life in people with insomnia. Sleep 1999; 22Suppl. 2: s379–85PubMed
47.
go back to reference Schramm E, Hohagen F, Grasshoff U, et al. Test-retest reliabilityand validity of the structured interview for sleep disorders according to DSM-III-R. Am J Psychiatry 1993; 150(6): 867–72PubMed Schramm E, Hohagen F, Grasshoff U, et al. Test-retest reliabilityand validity of the structured interview for sleep disorders according to DSM-III-R. Am J Psychiatry 1993; 150(6): 867–72PubMed
48.
go back to reference Buysse DJ, Reynolds III CF, Houck PR, et al. Age of illness onset and sleep EEG variables in elderly depressives. Biol Psychiatry 1988; 24(3): 355–9PubMedCrossRef Buysse DJ, Reynolds III CF, Houck PR, et al. Age of illness onset and sleep EEG variables in elderly depressives. Biol Psychiatry 1988; 24(3): 355–9PubMedCrossRef
49.
go back to reference Buysse DJ, Reynolds III CF, Monk TH, et al. Quantification ofsubjective sleep quality in healthy elderly men and womenusing the Pittsburgh Sleep Quality Index (PSQI). Sleep 1991; 14(4): 331–8PubMed Buysse DJ, Reynolds III CF, Monk TH, et al. Quantification ofsubjective sleep quality in healthy elderly men and womenusing the Pittsburgh Sleep Quality Index (PSQI). Sleep 1991; 14(4): 331–8PubMed
50.
go back to reference Douglass A, Carskadon M, Houser R. Historical database, questionnaires,sleep and life cycle diaries. In: Miles L, Broughton R, editors. Medical monitoring in the home and work environment. New York: The Raven Press, 1990 Douglass A, Carskadon M, Houser R. Historical database, questionnaires,sleep and life cycle diaries. In: Miles L, Broughton R, editors. Medical monitoring in the home and work environment. New York: The Raven Press, 1990
51.
go back to reference Morin CM. Psychological assessment and management. In:Morin CM, editor. Insomnia. New York: The Guilford Press,1993 Morin CM. Psychological assessment and management. In:Morin CM, editor. Insomnia. New York: The Guilford Press,1993
52.
go back to reference Hauri P, Fisher J. Persistent psychophysiologic (learned) insomnia. Sleep 1986; 9(1): 38–53PubMed Hauri P, Fisher J. Persistent psychophysiologic (learned) insomnia. Sleep 1986; 9(1): 38–53PubMed
53.
go back to reference Knab B, Engel RR. Perception of waking and sleeping: possibleimplications for the evaluation of insomnia. Sleep 1988; 11(3): 265–72PubMed Knab B, Engel RR. Perception of waking and sleeping: possibleimplications for the evaluation of insomnia. Sleep 1988; 11(3): 265–72PubMed
54.
go back to reference Pollak CP, Perlick D, Linsner JP. Daily sleep reports andcircadian rest-activity cycles of elderly community residents with insomnia. Biol Psychiatry 1992; 32(11): 1019–27PubMedCrossRef Pollak CP, Perlick D, Linsner JP. Daily sleep reports andcircadian rest-activity cycles of elderly community residents with insomnia. Biol Psychiatry 1992; 32(11): 1019–27PubMedCrossRef
55.
go back to reference Chambers MJ, Kim JY. The role of state-trait anxiety in insomniaand daytime restedness. Behav Med 1993; 19(1): 42–6PubMedCrossRef Chambers MJ, Kim JY. The role of state-trait anxiety in insomniaand daytime restedness. Behav Med 1993; 19(1): 42–6PubMedCrossRef
56.
go back to reference Brooks III JO, Friedman L, Bliwise DL, et al. Use of the wristactigraph to study insomnia in older adults. Sleep 1993; 16(2):151–5PubMed Brooks III JO, Friedman L, Bliwise DL, et al. Use of the wristactigraph to study insomnia in older adults. Sleep 1993; 16(2):151–5PubMed
57.
go back to reference Friedman L, Benson K, Noda A, et al. An actigraphic comparisonof sleep restriction and sleep hygiene treatments for insomniain older adults. J Geriatr Psychiatry Neurol 2000; 13(1):17–27PubMedCrossRef Friedman L, Benson K, Noda A, et al. An actigraphic comparisonof sleep restriction and sleep hygiene treatments for insomniain older adults. J Geriatr Psychiatry Neurol 2000; 13(1):17–27PubMedCrossRef
58.
go back to reference Krahn LE, Lin SC, Wisbey J, et al. Assessing sleep in psychiatricinpatients: nurse and patient reports versus wrist actigraphy. Ann Clin Psychiatry 1997; 9(4): 203–10PubMed Krahn LE, Lin SC, Wisbey J, et al. Assessing sleep in psychiatricinpatients: nurse and patient reports versus wrist actigraphy. Ann Clin Psychiatry 1997; 9(4): 203–10PubMed
59.
go back to reference Backhaus J, Junghanns K, Broocks A, et al. Test-retest reliabilityand validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res 2002; 53(3): 737–40PubMedCrossRef Backhaus J, Junghanns K, Broocks A, et al. Test-retest reliabilityand validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res 2002; 53(3): 737–40PubMedCrossRef
60.
go back to reference Chesson AL Jr, Murphy PW, Arnold CL, et al. Presentation andreading level of sleep brochures: are they appropriate for sleepdisorders patients? Sleep 1998; 21(4): 406–12PubMed Chesson AL Jr, Murphy PW, Arnold CL, et al. Presentation andreading level of sleep brochures: are they appropriate for sleepdisorders patients? Sleep 1998; 21(4): 406–12PubMed
61.
go back to reference Morin CM, Kowatch RA, Wade JB. Behavioral management of sleep disturbances secondary to chronic pain. J Behav Ther Exp Psychiatry 1989; 20(4): 295–302PubMedCrossRef Morin CM, Kowatch RA, Wade JB. Behavioral management of sleep disturbances secondary to chronic pain. J Behav Ther Exp Psychiatry 1989; 20(4): 295–302PubMedCrossRef
62.
go back to reference Perlis ML, Sharpe M, Smith MS, et al. Behavioral treatment ofinsomnia: treatment outcome and the relevance of medical andpsychiatric morbidity. J Behav Med 2001; 24(3): 281–96PubMedCrossRef Perlis ML, Sharpe M, Smith MS, et al. Behavioral treatment ofinsomnia: treatment outcome and the relevance of medical andpsychiatric morbidity. J Behav Med 2001; 24(3): 281–96PubMedCrossRef
63.
go back to reference Chesson AL Jr, Anderson WM, Littner M, et al. Practiceparameters for the nonpharmacologic treatment of chronicinsomnia: an American Academy of Sleep Medicine report: Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep 1999; 22(8): 1128–33PubMed Chesson AL Jr, Anderson WM, Littner M, et al. Practiceparameters for the nonpharmacologic treatment of chronicinsomnia: an American Academy of Sleep Medicine report: Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep 1999; 22(8): 1128–33PubMed
64.
go back to reference Morin CM, Hauri PJ, Espie CA, et al. Nonpharmacologictreatment of chronic insomnia: an American Academy of Sleep Medicine Review. Sleep 1999; 22(8): 1134–56PubMed Morin CM, Hauri PJ, Espie CA, et al. Nonpharmacologictreatment of chronic insomnia: an American Academy of Sleep Medicine Review. Sleep 1999; 22(8): 1134–56PubMed
65.
go back to reference Holbrook AM, Crowther R, Lotter A, et al. The diagnosis andmanagement of insomnia in clinical practice: a practical evidence-basedapproach. CMAJ 2000; 162(2): 216–20PubMed Holbrook AM, Crowther R, Lotter A, et al. The diagnosis andmanagement of insomnia in clinical practice: a practical evidence-basedapproach. CMAJ 2000; 162(2): 216–20PubMed
66.
go back to reference Smith MT, Perlis ML, Park A, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002; 159(1): 5–11PubMedCrossRef Smith MT, Perlis ML, Park A, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002; 159(1): 5–11PubMedCrossRef
67.
go back to reference National Commission on Sleep Disorder Research. Wake upAmerica: a national sleep alert: report of the National Commissionon Sleep Disorders Research. Palo Alto (CA): Departmentof Health and Human Services (DHHS), 1993 National Commission on Sleep Disorder Research. Wake upAmerica: a national sleep alert: report of the National Commissionon Sleep Disorders Research. Palo Alto (CA): Departmentof Health and Human Services (DHHS), 1993
68.
go back to reference Sackett DL. Rules of evidence and clinical recommendations for the management of patients. Can J Cardiol 1993; 9(6): 487–9PubMed Sackett DL. Rules of evidence and clinical recommendations for the management of patients. Can J Cardiol 1993; 9(6): 487–9PubMed
69.
go back to reference Hohagen F, Rink K, Kappler C, et al. Prevalence and treatment of insomnia in general practice: a longitudinal study. Eur Arch Psychiatry Clin Neurosci 1993; 242(6): 329–36PubMedCrossRef Hohagen F, Rink K, Kappler C, et al. Prevalence and treatment of insomnia in general practice: a longitudinal study. Eur Arch Psychiatry Clin Neurosci 1993; 242(6): 329–36PubMedCrossRef
70.
go back to reference Stiefel F, Berney A, Mazzocato C. Psychopharmacology insupportive care in cancer: a review for the clinician: I. Benzodiazepines.Support Care Cancer 1999; 7(6): 379–85CrossRef Stiefel F, Berney A, Mazzocato C. Psychopharmacology insupportive care in cancer: a review for the clinician: I. Benzodiazepines.Support Care Cancer 1999; 7(6): 379–85CrossRef
71.
go back to reference Greenblatt DJ, Shader RI. Dependence, tolerance, and addictionto benzodiazepines: clinical and pharmakinetic considerations. Drug Metab Rev 1978; 8(1): 13–28PubMedCrossRef Greenblatt DJ, Shader RI. Dependence, tolerance, and addictionto benzodiazepines: clinical and pharmakinetic considerations. Drug Metab Rev 1978; 8(1): 13–28PubMedCrossRef
72.
go back to reference Berney A, Stiefel F, Mazzocato C, et al. Psychopharmacologyin supportive care of cancer: a review for the clinician: III.Antidepressants. Support Care Cancer 2000; 8: 278–86PubMed Berney A, Stiefel F, Mazzocato C, et al. Psychopharmacologyin supportive care of cancer: a review for the clinician: III.Antidepressants. Support Care Cancer 2000; 8: 278–86PubMed
73.
go back to reference McCracken LM, Iverson GL. Predicting complaints of impairedcognitive functionning in patients with chronic pain. J Pain Symptom Manage 2001; 21(5): 392–6PubMedCrossRef McCracken LM, Iverson GL. Predicting complaints of impairedcognitive functionning in patients with chronic pain. J Pain Symptom Manage 2001; 21(5): 392–6PubMedCrossRef
74.
go back to reference Wysowski DK, Schober SE, Wise RP, et al. Mortality attributedto misuse of psychoactive drugs, 1979–88. Public Health Rep 1993; 108(5): 565–70PubMed Wysowski DK, Schober SE, Wise RP, et al. Mortality attributedto misuse of psychoactive drugs, 1979–88. Public Health Rep 1993; 108(5): 565–70PubMed
75.
go back to reference Wysowski DK, Barash D. Adverse behavioral reactions attributedto triazolam in the Food and Drug Administration’s Spontaneous Reporting System. Arch Intern Med 1991; 151(10):2003–8PubMedCrossRef Wysowski DK, Barash D. Adverse behavioral reactions attributedto triazolam in the Food and Drug Administration’s Spontaneous Reporting System. Arch Intern Med 1991; 151(10):2003–8PubMedCrossRef
76.
go back to reference Wysowski DK, Baum C. Outpatient use of prescription sedative-hypnotic drugs in the United States, 1970 through 1989. Arch Intern Med 1991; 151(9): 1779–83PubMedCrossRef Wysowski DK, Baum C. Outpatient use of prescription sedative-hypnotic drugs in the United States, 1970 through 1989. Arch Intern Med 1991; 151(9): 1779–83PubMedCrossRef
77.
go back to reference Hättenschwiler J, Hatzinger M. Diagnostic des troubles du sommeil. Schweiz Med Forum 2001; 1(11): 265–76 Hättenschwiler J, Hatzinger M. Diagnostic des troubles du sommeil. Schweiz Med Forum 2001; 1(11): 265–76
78.
go back to reference Portenoy R. Adjuvant analgesics in pain management. In: MacDonal dL, editor. Oxford textbook of palliative medicine. 2nd ed. Oxford: Oxford University Press, 1998: 361–90 Portenoy R. Adjuvant analgesics in pain management. In: MacDonal dL, editor. Oxford textbook of palliative medicine. 2nd ed. Oxford: Oxford University Press, 1998: 361–90
79.
go back to reference Magni G. The use of antidepressants in the treatment of chronic pain: a review of the current evidence. Drugs 1991; 42(5): 730–48PubMedCrossRef Magni G. The use of antidepressants in the treatment of chronic pain: a review of the current evidence. Drugs 1991; 42(5): 730–48PubMedCrossRef
80.
go back to reference Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 1992; 49(2): 205–19PubMedCrossRef Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 1992; 49(2): 205–19PubMedCrossRef
81.
go back to reference Max MB, Culnane M, Schafer SC, et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37(4): 589–96PubMedCrossRef Max MB, Culnane M, Schafer SC, et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37(4): 589–96PubMedCrossRef
82.
go back to reference Breitbart W. Psychotropic adjuvant analgesics for pain in cancer and AIDS. Psychooncology 1998; 7(4): 333–45PubMedCrossRef Breitbart W. Psychotropic adjuvant analgesics for pain in cancer and AIDS. Psychooncology 1998; 7(4): 333–45PubMedCrossRef
83.
go back to reference Mazzocato C, Stiefel F, Buclin T, et al. Psychopharmacology insupportive care of cancer: a review for the clinician: II. Neuroleptics. J Support Care Cancer 2000; 8: 89–97CrossRef Mazzocato C, Stiefel F, Buclin T, et al. Psychopharmacology insupportive care of cancer: a review for the clinician: II. Neuroleptics. J Support Care Cancer 2000; 8: 89–97CrossRef
84.
go back to reference Bloomfield S, Simard-Savoy S, Bernier J, et al. Comparative analgesic activity of levopromazine and morphine in patients with chronic pain. Can Med Assoc J 1964; (90): 1156-9 Bloomfield S, Simard-Savoy S, Bernier J, et al. Comparative analgesic activity of levopromazine and morphine in patients with chronic pain. Can Med Assoc J 1964; (90): 1156-9
85.
go back to reference Beaver WT, Wallenstein SL, Houde RW, et al. A comparison of the analgesic effects of methotrimeprazine and morphine in patients with cancer. Clin Pharmacol Ther 1966; 7(4): 436–46PubMed Beaver WT, Wallenstein SL, Houde RW, et al. A comparison of the analgesic effects of methotrimeprazine and morphine in patients with cancer. Clin Pharmacol Ther 1966; 7(4): 436–46PubMed
86.
go back to reference Davidsen O, Lindeneg O, Walsh M. Analgesic treatment with levomepromazine in acute myocardial infarction. A randomized clinical trial. Acta Med Scand 1979; 205(3): 191–4 Davidsen O, Lindeneg O, Walsh M. Analgesic treatment with levomepromazine in acute myocardial infarction. A randomized clinical trial. Acta Med Scand 1979; 205(3): 191–4
87.
go back to reference Lasagna L, DeKornfeld T. Methotrimeprazine, a new phenothiazine derivative with analgesic properties. JAMA 1961; (178): 887-90 Lasagna L, DeKornfeld T. Methotrimeprazine, a new phenothiazine derivative with analgesic properties. JAMA 1961; (178): 887-90
88.
go back to reference Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol Alcohol 1995; 30(6): 771–4PubMed Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol Alcohol 1995; 30(6): 771–4PubMed
89.
go back to reference Ather SA, Shaw SH, Stoker MJ. A comparison of chlormethiazole and thioridazine in agitated confusional states of the elderly. Acta Psychiatr Scand Suppl 1986; 329: 81–91PubMedCrossRef Ather SA, Shaw SH, Stoker MJ. A comparison of chlormethiazole and thioridazine in agitated confusional states of the elderly. Acta Psychiatr Scand Suppl 1986; 329: 81–91PubMedCrossRef
90.
go back to reference Dehlin O. Hypnotic effect of chlormethiazole in geriatric patients during long-term treatment. Acta Psychiatr Scand Suppl 1986; 329: 112–5PubMedCrossRef Dehlin O. Hypnotic effect of chlormethiazole in geriatric patients during long-term treatment. Acta Psychiatr Scand Suppl 1986; 329: 112–5PubMedCrossRef
91.
go back to reference Gray PA, Park GR. Chlormethiazole sedation for critically ill patients in renal failure. Anaesthesia 1989; 44(11): 913–5PubMedCrossRef Gray PA, Park GR. Chlormethiazole sedation for critically ill patients in renal failure. Anaesthesia 1989; 44(11): 913–5PubMedCrossRef
92.
go back to reference Overstall PW, Oldman PN. A comparative study of lormetazepam and chlormethiazole in elderly in-patients. Age Ageing 1987; 16(1): 45–51PubMedCrossRef Overstall PW, Oldman PN. A comparative study of lormetazepam and chlormethiazole in elderly in-patients. Age Ageing 1987; 16(1): 45–51PubMedCrossRef
93.
go back to reference Buclin T, Mazzocato C, Berney A, et al. Psychopharmacology in supportive care of cancer: a review for the clinician: IV Other psychotropic agents. Support Care Cancer 2001; 99: 213–22 Buclin T, Mazzocato C, Berney A, et al. Psychopharmacology in supportive care of cancer: a review for the clinician: IV Other psychotropic agents. Support Care Cancer 2001; 99: 213–22
94.
go back to reference Zhdanova IV, Lynch HJ, Wurtman RJ. Melatonin: a sleep-promoting hormone. Sleep 1997; 20(10): 899–907PubMed Zhdanova IV, Lynch HJ, Wurtman RJ. Melatonin: a sleep-promoting hormone. Sleep 1997; 20(10): 899–907PubMed
95.
go back to reference Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995; 57(5): 552–8PubMedCrossRef Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995; 57(5): 552–8PubMedCrossRef
96.
go back to reference Lissoni P, Paolorossi F, Tancini G, et al. Is there a role for melatonin in the treatment of neoplastic cachexia? Eur J Cancer 1996; 32A(8): 1340–3PubMedCrossRef Lissoni P, Paolorossi F, Tancini G, et al. Is there a role for melatonin in the treatment of neoplastic cachexia? Eur J Cancer 1996; 32A(8): 1340–3PubMedCrossRef
Metadata
Title
Management of Insomnia in Patients with Chronic Pain Conditions
Authors
Prof. Frederic Stiefel
Daniele Stagno
Publication date
01-04-2004
Publisher
Springer International Publishing
Published in
CNS Drugs / Issue 5/2004
Print ISSN: 1172-7047
Electronic ISSN: 1179-1934
DOI
https://doi.org/10.2165/00023210-200418050-00002