Skip to main content
Top
Published in: PharmacoEconomics 11/2006

01-11-2006 | Conference Paper

Economic Evaluation and Decision Making in the UK

Author: Professor Martin J. Buxton

Published in: PharmacoEconomics | Issue 11/2006

Login to get access

Abstract

This article reviews the development of economic evaluation of health technologies in the UK and its impact on decision making. After a long period of limited impact from studies mainly carried out as academic exercises, the advent of the National Institute for Health and Clinical Excellence (NICE) in 1999 provided a transparent decision-making context where economic evaluation plays a central role. This article reviews some of the key characteristics about the way NICE works, for example, the way NICE has defined the form of analysis that it requires, reflecting its objective of maximising health gain (QALYs) from the predetermined and limited UK NHS budget.
Two broad areas of widespread concern are noted. The first relates to the cost-effectiveness thresholds that NICE uses and the basis for them. The second is the patchy implementation of NICE guidance and the possible reasons for this. But even within the UK, NICE is the exception in making extensive and explicit use of economic evaluation and this article goes on to suggest that if there is to be a more widespread and consistent use of economic evaluation at both central and local levels, then health economists and others need to address three issues.
The first is to be clear about what is the correct conceptual basis for determining the cost-effectiveness threshold and then to ensure that NICE has the empirical evidence to set it appropriately. The second is to recognise that even using the limited view of costs adopted by NICE, economic evaluations imply temporal and cross-service budgetary flexibility that the NHS locally does not in practice enjoy. The third issue is that with academic pressures for ever-increasing sophistication of ‘state of the art’ economic evaluation analysis, the NHS has more and more precise understanding of the cost effectiveness of just a few new technologies and little or no analysis of most. This limits the value of the former by reducing further the scope for appropriately disinvesting from cost-ineffective technologies to meet the additional costs of investing in cost-effective new ones.
Whilst NICE stands out as an example of a context where high-quality economic evaluation plays a major role in decision making, the process is far from perfect and certainly is not representative of the use made of economic evaluation by the NHS as a whole. Health economists need to engage with the public and the health service to better understand their perspectives, rather than focusing on academic concerns relating to details of theory and analytical method.
Footnotes
1
The concern that what may centrally be deemed to be cost effective in terms of a nationally determined ICER may not be cost effective when operationalised locally is one of the issues at the heart of Birch and Gafni’s critique of the (unthinking)use of ICERs included in this issue.[29]
 
Literature
1.
go back to reference Pole JD. Economic aspects of screening for disease. In: McKeown T, editor. Screening in medical care. London: CUP and Nuffield PHT, 1969 Pole JD. Economic aspects of screening for disease. In: McKeown T, editor. Screening in medical care. London: CUP and Nuffield PHT, 1969
2.
go back to reference Pole JD. The economic of mass radiography. In: Hauser MM, editor. The economics of medical care. London: George Allen and Unwin Ltd, 1972 Pole JD. The economic of mass radiography. In: Hauser MM, editor. The economics of medical care. London: George Allen and Unwin Ltd, 1972
3.
go back to reference Brassard P, Steensma C, Cadieux L, et al. Evaluation of a school-based tuberculosis-screening program and associate investigation targeting recently immigrated children in a low-burden country. Pediatrics 2006 Feb; 117: e148–e156PubMedCrossRef Brassard P, Steensma C, Cadieux L, et al. Evaluation of a school-based tuberculosis-screening program and associate investigation targeting recently immigrated children in a low-burden country. Pediatrics 2006 Feb; 117: e148–e156PubMedCrossRef
4.
go back to reference Drummond MF. Principles of economic evaluation in health care. Oxford: Oxford University Press, 1980 Drummond MF. Principles of economic evaluation in health care. Oxford: Oxford University Press, 1980
5.
go back to reference Buxton M, Acheson R, Caine N, et al. Costs and benefits of the heart transplant programmes at Harefield and Papworth Hospitals. London: HMSO, 1985 Buxton M, Acheson R, Caine N, et al. Costs and benefits of the heart transplant programmes at Harefield and Papworth Hospitals. London: HMSO, 1985
6.
go back to reference Drummond M, Cooke J, Walley T. Economic evaluation under managed competition: evidence from the UK. Soc Sci Med 1997; 45 (4): 583–595PubMedCrossRef Drummond M, Cooke J, Walley T. Economic evaluation under managed competition: evidence from the UK. Soc Sci Med 1997; 45 (4): 583–595PubMedCrossRef
7.
go back to reference Buxton M. Heart transplantation in the UK: the decision-making context of an economic evaluation. In: Stocking B, editor. Expensive health technologies: regulatory and administrative mechanisms in Europe. Commission of the European Communities, Health Services Research Series, no. 5. Oxford: Oxford University Press, 1988 Buxton M. Heart transplantation in the UK: the decision-making context of an economic evaluation. In: Stocking B, editor. Expensive health technologies: regulatory and administrative mechanisms in Europe. Commission of the European Communities, Health Services Research Series, no. 5. Oxford: Oxford University Press, 1988
8.
go back to reference Stowe K, editor. On caring for the national health. London: The Nuffield Provincial Hospitals Trust, 1988 Stowe K, editor. On caring for the national health. London: The Nuffield Provincial Hospitals Trust, 1988
9.
go back to reference Hanney SR, Gonzalez-Block MA, Buxton MJ, et al. The utilisation of health research in policy-making: concepts, examples and methods of assessment. Health Res Policy Syst 2003 Jan; 1: 2PubMedCrossRef Hanney SR, Gonzalez-Block MA, Buxton MJ, et al. The utilisation of health research in policy-making: concepts, examples and methods of assessment. Health Res Policy Syst 2003 Jan; 1: 2PubMedCrossRef
10.
go back to reference Hurst J. The impact of health economics on health policy in England, and the impact of health policy on health economics. Health Econ 1998; 7: S47–S62PubMedCrossRef Hurst J. The impact of health economics on health policy in England, and the impact of health policy on health economics. Health Econ 1998; 7: S47–S62PubMedCrossRef
11.
go back to reference Duthie T, Trueman P, Chancellor J, et al. Research into the use of health economics in decision making in the United Kingdom: phase II: Is health economics ‘for good or evil’? Health Policy 1999; 46: 143–157PubMedCrossRef Duthie T, Trueman P, Chancellor J, et al. Research into the use of health economics in decision making in the United Kingdom: phase II: Is health economics ‘for good or evil’? Health Policy 1999; 46: 143–157PubMedCrossRef
12.
go back to reference Hoffmann C, Graf von der Schulenburg J-MG, on behalf of the EUROMET group. The influence of economic evaluation studies on decision making: a European survey. Health Policy 2000; 52: 179–192PubMedCrossRef Hoffmann C, Graf von der Schulenburg J-MG, on behalf of the EUROMET group. The influence of economic evaluation studies on decision making: a European survey. Health Policy 2000; 52: 179–192PubMedCrossRef
13.
go back to reference Birkett DJ, Mitchell AS, McManus P. A cost-effectiveness approach to drug subsidy and pricing in Australia. Health Aff 2001; 20 (3): 104–114CrossRef Birkett DJ, Mitchell AS, McManus P. A cost-effectiveness approach to drug subsidy and pricing in Australia. Health Aff 2001; 20 (3): 104–114CrossRef
14.
go back to reference PausJenssen AM, Singer PA, Detsky AS. Ontario’s formulary committee: how recommendations are made. Pharmacoeconomics 2003; 21 (4): 285–294PubMedCrossRef PausJenssen AM, Singer PA, Detsky AS. Ontario’s formulary committee: how recommendations are made. Pharmacoeconomics 2003; 21 (4): 285–294PubMedCrossRef
15.
go back to reference National Institute for Clinical Excellence [online]. Available from URL: http://www.nice.org.uk [Accessed 2006 Aug 14] National Institute for Clinical Excellence [online]. Available from URL: http://​www.​nice.​org.​uk [Accessed 2006 Aug 14]
16.
go back to reference Appleby J, Devlin N. British health economists: is what they do what they should be doing? CES/HESG Workshop; 2004 Jan 14–16; Paris Appleby J, Devlin N. British health economists: is what they do what they should be doing? CES/HESG Workshop; 2004 Jan 14–16; Paris
17.
go back to reference Raftery J. NICE: faster access to modern treatments? Analysis of guidance on health technologies. BMJ 2001 Dec; 323: 1300–1303PubMedCrossRef Raftery J. NICE: faster access to modern treatments? Analysis of guidance on health technologies. BMJ 2001 Dec; 323: 1300–1303PubMedCrossRef
18.
19.
go back to reference Hill S, Garattini S, van Loenhout, et al. Technology appraisal programme of the National Institute for Clinical Excellence: a review by WHO. World Health Organization, 2003 [online]. Available from URL: http://www.nice.org.uk/ page.aspx?o=85797 [Accessed 2006 Aug 25] Hill S, Garattini S, van Loenhout, et al. Technology appraisal programme of the National Institute for Clinical Excellence: a review by WHO. World Health Organization, 2003 [online]. Available from URL: http://​www.​nice.​org.​uk/​ page.aspx?o=85797 [Accessed 2006 Aug 25]
20.
go back to reference Bryan S, Williams I, McIver S. Seeing the NICE side of cost-effectiveness analysis: a qualitative investigation of the use of CEA in NICE technology appraisals. Health Econ. Epub 2006 Sep 7 Bryan S, Williams I, McIver S. Seeing the NICE side of cost-effectiveness analysis: a qualitative investigation of the use of CEA in NICE technology appraisals. Health Econ. Epub 2006 Sep 7
21.
go back to reference National Institute for Health and Clinical Excellence. Guides to the methods of technology appraisal (reference N0515). London: NICE, 2004 National Institute for Health and Clinical Excellence. Guides to the methods of technology appraisal (reference N0515). London: NICE, 2004
22.
go back to reference Rawlins MD, Culyer AJ. National Institute for Clinical Excellence and its value judgments. BMJ 2004 Jul; 329: 224–227PubMedCrossRef Rawlins MD, Culyer AJ. National Institute for Clinical Excellence and its value judgments. BMJ 2004 Jul; 329: 224–227PubMedCrossRef
23.
go back to reference Devlin N, Parkin D. Does NICE have a cost-effectiveness threshold and what other factors influence its decisions? A binary choice analysis. Health Econ 2004; 13: 437–452PubMedCrossRef Devlin N, Parkin D. Does NICE have a cost-effectiveness threshold and what other factors influence its decisions? A binary choice analysis. Health Econ 2004; 13: 437–452PubMedCrossRef
24.
go back to reference Dakin HA, Devlin NJ, Odeyemi IAO. “Yes”, “no” or “yes, but”? Multinomial modelling of NICE decision-making. Health Policy 2006; 77: 352–367PubMedCrossRef Dakin HA, Devlin NJ, Odeyemi IAO. “Yes”, “no” or “yes, but”? Multinomial modelling of NICE decision-making. Health Policy 2006; 77: 352–367PubMedCrossRef
25.
go back to reference Sheldon TA, Cullum N, Dawson D, et al. What’s the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients’ notes, and interviews. BMJ 2004 Oct; 329: 999–1003PubMedCrossRef Sheldon TA, Cullum N, Dawson D, et al. What’s the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients’ notes, and interviews. BMJ 2004 Oct; 329: 999–1003PubMedCrossRef
26.
go back to reference National Institute for Health and Clinical Excellence. Minister of State’s letter on implementation of NICE guidance. London: NICE, 2004 National Institute for Health and Clinical Excellence. Minister of State’s letter on implementation of NICE guidance. London: NICE, 2004
27.
go back to reference Buxton MJ. How much are health-care systems prepared to pay to produce a QALY? Eur J Health Econ 2005; 4: 285–287CrossRef Buxton MJ. How much are health-care systems prepared to pay to produce a QALY? Eur J Health Econ 2005; 4: 285–287CrossRef
28.
go back to reference Culyer AJ, McCabe C, Briggs AH, et al. Searching for a threshold, not setting one: the role of the National Institute of Health and Clinical Excellence. J Health Serv Res Policy. In press Culyer AJ, McCabe C, Briggs AH, et al. Searching for a threshold, not setting one: the role of the National Institute of Health and Clinical Excellence. J Health Serv Res Policy. In press
29.
go back to reference Birch S, Gafni A. Information created to evade reality (ICER): things we should not look to for answers. Pharmacoeconomics 2006; 24 (11): 1121–1131PubMedCrossRef Birch S, Gafni A. Information created to evade reality (ICER): things we should not look to for answers. Pharmacoeconomics 2006; 24 (11): 1121–1131PubMedCrossRef
30.
go back to reference Maynard A, Street A. Seven years of feast, seven years of famine: boom to bust in the NHS? BMJ 2006 Apr; 332: 906–908PubMedCrossRef Maynard A, Street A. Seven years of feast, seven years of famine: boom to bust in the NHS? BMJ 2006 Apr; 332: 906–908PubMedCrossRef
31.
go back to reference O’Brien BJ, Gersten K, Willan AR, et al. Is there a kink in consumers’ threshold value for cost-effectiveness in health care? Health Econ 2002; 11: 175–180PubMedCrossRef O’Brien BJ, Gersten K, Willan AR, et al. Is there a kink in consumers’ threshold value for cost-effectiveness in health care? Health Econ 2002; 11: 175–180PubMedCrossRef
32.
go back to reference Severens JL, Brunenberg DEM, Fenwick EAL, et al. Cost-effectiveness acceptability curves and a reluctance to lose. Pharmacoeconomics 2005; 23 (12): 1207–1214PubMedCrossRef Severens JL, Brunenberg DEM, Fenwick EAL, et al. Cost-effectiveness acceptability curves and a reluctance to lose. Pharmacoeconomics 2005; 23 (12): 1207–1214PubMedCrossRef
33.
go back to reference Dowie J. No room for kinkiness in a public healthcare system. Pharmacoeconomics 2005; 23 (12): 1203–1205PubMedCrossRef Dowie J. No room for kinkiness in a public healthcare system. Pharmacoeconomics 2005; 23 (12): 1203–1205PubMedCrossRef
34.
go back to reference Maynard A, Bloor K, Freemantle N. Challenges for the National Institute for Clinical Excellence. BMJ 2004; 329: 227–229PubMedCrossRef Maynard A, Bloor K, Freemantle N. Challenges for the National Institute for Clinical Excellence. BMJ 2004; 329: 227–229PubMedCrossRef
35.
go back to reference Buxton MJ, Akehurst R. How NICE is the UK’s fast-track system? Scrip 2006 Mar: 24–25 Buxton MJ, Akehurst R. How NICE is the UK’s fast-track system? Scrip 2006 Mar: 24–25
36.
go back to reference National Institute for Health and Clinical Excellence. Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer. NICE appraisal guidance 107 [online]. London: NICE, 2006. Available from URL: http://www.nice.org.uk/page.aspx?o=TA107guidance [Accessed 2006 Aug 25] National Institute for Health and Clinical Excellence. Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer. NICE appraisal guidance 107 [online]. London: NICE, 2006. Available from URL: http://​www.​nice.​org.​uk/​page.​aspx?​o=​TA107guidance [Accessed 2006 Aug 25]
37.
go back to reference Claxton K, Sculpher M, McCabe C, et al. Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra. Health Econ 2005; 14: 339–347PubMedCrossRef Claxton K, Sculpher M, McCabe C, et al. Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra. Health Econ 2005; 14: 339–347PubMedCrossRef
38.
go back to reference Cairns J. Providing guidance to the NHS: the Scottish medicines consortium and the National Institute for Clinical Excellence compared. Health Policy 2006; 76: 134–143PubMedCrossRef Cairns J. Providing guidance to the NHS: the Scottish medicines consortium and the National Institute for Clinical Excellence compared. Health Policy 2006; 76: 134–143PubMedCrossRef
39.
go back to reference Cookson R, McDaid D, Maynard A. Wrong SIGN, NICE mess: is national guidance distorting allocation of resources? BMJ 2001; 32: 743–745CrossRef Cookson R, McDaid D, Maynard A. Wrong SIGN, NICE mess: is national guidance distorting allocation of resources? BMJ 2001; 32: 743–745CrossRef
Metadata
Title
Economic Evaluation and Decision Making in the UK
Author
Professor Martin J. Buxton
Publication date
01-11-2006
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 11/2006
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200624110-00009

Other articles of this Issue 11/2006

PharmacoEconomics 11/2006 Go to the issue