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Published in: PharmacoEconomics 5/2006

01-05-2006 | Review Article

Cost Effectiveness of Preventive Interventions in Type 2 Diabetes Mellitus

A Systematic Literature Review

Authors: Sylvia M. C. Vijgen, Mirjam Hoogendoorn, Caroline A. Baan, G. Ardine de Wit, Wien Limburg, Talitha L. Feenstra

Published in: PharmacoEconomics | Issue 5/2006

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Abstract

A systematic review of the literature was conducted to give an overview of economic evaluations of preventive interventions in type 2 diabetes mellitus. The interventions were sorted by type of preventive intervention (primary, secondary or tertiary) and by category (e.g. education, medication for hypertension). Several databases were searched for studies published between January 1990 and May 2004 on the three types of preventive intervention. For each study selected, inclusion of specific components from a standardised list of items, including quality, was recorded in a database. Summary tables were generated based on the database.
A number of conclusions were drawn from this review. The most important was that strict blood pressure control was a more cost-effective intervention than less strict control, as shown by six studies reporting cost savings to very low costs per life-year gained. Primary and secondary prevention of type 2 diabetes were also highly cost effective, but these results were based on very few studies. Medications to reduce weight and hyperglycaemia together were cost effective compared with conventional interventions. Finally, the separate results regarding medications to reduce weight, hyperglycaemia and hypercholesterolaemia varied enormously, thus no conclusion could be drawn and further economic analysis is required.
Literature
1.
go back to reference Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27 (5): 1047–1053PubMedCrossRef Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27 (5): 1047–1053PubMedCrossRef
2.
go back to reference Harris MI, Aegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults: the Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 1998 Apr; 21 (4): 518–524PubMedCrossRef Harris MI, Aegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults: the Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 1998 Apr; 21 (4): 518–524PubMedCrossRef
3.
go back to reference Borch-Johnsen K, Lauritzen T, Glumer C, et al. Screening for type 2 diabetes: should it be now? Diabet Med 2003; 20 (3): 175–181PubMedCrossRef Borch-Johnsen K, Lauritzen T, Glumer C, et al. Screening for type 2 diabetes: should it be now? Diabet Med 2003; 20 (3): 175–181PubMedCrossRef
4.
go back to reference American Diabetes Association. Screening for type 2 diabetes. Diabetes Care 2004; 27 Suppl. 1: S11–S14CrossRef American Diabetes Association. Screening for type 2 diabetes. Diabetes Care 2004; 27 Suppl. 1: S11–S14CrossRef
5.
go back to reference van Os N, Niessen LW, Koopmanschap MA, et al. Detailed analysis of the societal costs of diabetes mellitus [in Dutch]. Ned Tijdschr Geneeskd 2000; 144 (18): 842–846PubMed van Os N, Niessen LW, Koopmanschap MA, et al. Detailed analysis of the societal costs of diabetes mellitus [in Dutch]. Ned Tijdschr Geneeskd 2000; 144 (18): 842–846PubMed
6.
go back to reference Raikou M, McGuire A. The economics of screening and treatment in type 2 diabetes mellitus. Pharmacoeconomics 2003; 21 (8), 543–564PubMedCrossRef Raikou M, McGuire A. The economics of screening and treatment in type 2 diabetes mellitus. Pharmacoeconomics 2003; 21 (8), 543–564PubMedCrossRef
7.
go back to reference Klonoff DC, Schwartz DM. An economic analysis of interventions for diabetes. Diabetes Care 2000; 23 (3): 390–404PubMedCrossRef Klonoff DC, Schwartz DM. An economic analysis of interventions for diabetes. Diabetes Care 2000; 23 (3): 390–404PubMedCrossRef
8.
go back to reference Zhang P, Engelgau M, Norris SL. Application of economic analysis to diabetes and diabetes care. Ann Intern Med 2004; 140 (11): 972–977PubMed Zhang P, Engelgau M, Norris SL. Application of economic analysis to diabetes and diabetes care. Ann Intern Med 2004; 140 (11): 972–977PubMed
9.
go back to reference Clarke P, Gray A, Adler A, et al. Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51). Diabetologia 2001; 44 (3): 298–304PubMedCrossRef Clarke P, Gray A, Adler A, et al. Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51). Diabetologia 2001; 44 (3): 298–304PubMedCrossRef
10.
go back to reference Gray A, Clarke P, Raikou M, et al. An economic evaluation of atenolol vs captopril in patients with type 2 diabetes (UKPDS 54). Diabet Med 2001; 18 (6): 438–444PubMedCrossRef Gray A, Clarke P, Raikou M, et al. An economic evaluation of atenolol vs captopril in patients with type 2 diabetes (UKPDS 54). Diabet Med 2001; 18 (6): 438–444PubMedCrossRef
11.
go back to reference UK Prospective Diabetes Study Group. Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40. BMJ 1998 Sep 12; 317 (7160): 720–726CrossRef UK Prospective Diabetes Study Group. Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40. BMJ 1998 Sep 12; 317 (7160): 720–726CrossRef
12.
go back to reference Drummond MF, Jefferson TO. Guidelines for authors and peer reviewers of economic submissions to the BMJ. BMJ 1996 Aug; 313: 275–283PubMedCrossRef Drummond MF, Jefferson TO. Guidelines for authors and peer reviewers of economic submissions to the BMJ. BMJ 1996 Aug; 313: 275–283PubMedCrossRef
13.
go back to reference O’Connor PJ, Rush W A, Cherney LM, et al. Screening for diabetes mellitus in high-risk patients: cost, yield, and acceptability. Eff Clin Pract 2001; 4 (6): 271–277PubMed O’Connor PJ, Rush W A, Cherney LM, et al. Screening for diabetes mellitus in high-risk patients: cost, yield, and acceptability. Eff Clin Pract 2001; 4 (6): 271–277PubMed
14.
go back to reference Law AV, Pathak DS, Segraves AM, et al. Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic. Clin Ther 1995; 17 (5), 977–987PubMedCrossRef Law AV, Pathak DS, Segraves AM, et al. Cost-effectiveness analyses of the conversion of patients with non-insulin-dependent diabetes mellitus from glipizide to glyburide and of the accompanying pharmacy follow-up clinic. Clin Ther 1995; 17 (5), 977–987PubMedCrossRef
15.
go back to reference Trento M, Passera P, Bajardi M, et al. Lifestyle intervention by group care prevents deterioration of type II diabetes: a 4-year randomized controlled clinical trial. Diabetologia 2002; 45 (9): 1231–1239PubMedCrossRef Trento M, Passera P, Bajardi M, et al. Lifestyle intervention by group care prevents deterioration of type II diabetes: a 4-year randomized controlled clinical trial. Diabetologia 2002; 45 (9): 1231–1239PubMedCrossRef
16.
go back to reference Glasgow RE, Chance PAL, Toobert DJ, et al. Long-term effects and costs of brief behavioural dietary intervention for patients with diabetes delivered from the medical office. Patient Educ Couns 1997; 32 (3): 175–184PubMedCrossRef Glasgow RE, Chance PAL, Toobert DJ, et al. Long-term effects and costs of brief behavioural dietary intervention for patients with diabetes delivered from the medical office. Patient Educ Couns 1997; 32 (3): 175–184PubMedCrossRef
17.
go back to reference The Diabetes Prevention Program Research Group. Within-trial cost-effectiveness of lifestyle intervention or metformin for the primary prevention of type 2 diabetes. Diabetes Care 2003; 26 (9), 2518–2523CrossRef The Diabetes Prevention Program Research Group. Within-trial cost-effectiveness of lifestyle intervention or metformin for the primary prevention of type 2 diabetes. Diabetes Care 2003; 26 (9), 2518–2523CrossRef
18.
go back to reference Gray A, Raikou M, McGuire A, et al. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomized controlled trial (UKPDS 41). The United Kingdom Prospective Diabetes Study (UKPDS) Group. BMJ 2000; 320: 1373–1378PubMedCrossRef Gray A, Raikou M, McGuire A, et al. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomized controlled trial (UKPDS 41). The United Kingdom Prospective Diabetes Study (UKPDS) Group. BMJ 2000; 320: 1373–1378PubMedCrossRef
19.
go back to reference Jonsson B, Hansson L, Stalhammar NO. Health economics in the Hypertension Optimal Treatment (HOT) study: costs and cost-effectiveness of intensive blood pressure lowering and low-dose aspirin in patients with hypertension. J Intern Med 2003; 253 (4): 472–480PubMedCrossRef Jonsson B, Hansson L, Stalhammar NO. Health economics in the Hypertension Optimal Treatment (HOT) study: costs and cost-effectiveness of intensive blood pressure lowering and low-dose aspirin in patients with hypertension. J Intern Med 2003; 253 (4): 472–480PubMedCrossRef
20.
go back to reference Brown RR. Cost-effectiveness and clinical outcomes of metformin or insulin add-on therapy in adults with type 2 diabetes. Am J Health Syst Phann 1998; 55 (24 Suppl. 4): S24–S27 Brown RR. Cost-effectiveness and clinical outcomes of metformin or insulin add-on therapy in adults with type 2 diabetes. Am J Health Syst Phann 1998; 55 (24 Suppl. 4): S24–S27
21.
go back to reference Souchet T, Durand Zaleski I, Hannedouche T, et al. An economic evaluation of Losartan therapy in type 2 diabetic patients with nephropathy: an analysis of the RENAAL study adapted to France. Diabetes Metab 2003; 29 (1): 29–35PubMedCrossRef Souchet T, Durand Zaleski I, Hannedouche T, et al. An economic evaluation of Losartan therapy in type 2 diabetic patients with nephropathy: an analysis of the RENAAL study adapted to France. Diabetes Metab 2003; 29 (1): 29–35PubMedCrossRef
22.
go back to reference Hoerger TJ, Harris R, Hicks KA, et al. Screening for type 2 diabetes mellitus: a cost-effectiveness analysis. Ann Intern Med 2004; 140 (9): 689–699PubMed Hoerger TJ, Harris R, Hicks KA, et al. Screening for type 2 diabetes mellitus: a cost-effectiveness analysis. Ann Intern Med 2004; 140 (9): 689–699PubMed
23.
go back to reference Segal L, Dalton AC, Richardson J. Cost-effectiveness of the primary prevention of non-insulin dependent diabetes mellitus. Health Promot Int 1998; 13 (3): 197–209CrossRef Segal L, Dalton AC, Richardson J. Cost-effectiveness of the primary prevention of non-insulin dependent diabetes mellitus. Health Promot Int 1998; 13 (3): 197–209CrossRef
24.
go back to reference Elliott WJ, Weir DR, Black HR. Cost-effectiveness of the lower treatment goal (of JNC VI) for diabetic hypertensive patients: Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 2000; 160 (9): 1277–1283PubMedCrossRef Elliott WJ, Weir DR, Black HR. Cost-effectiveness of the lower treatment goal (of JNC VI) for diabetic hypertensive patients: Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 2000; 160 (9): 1277–1283PubMedCrossRef
25.
go back to reference Gozzoli V, Palmer AJ, Brandt A, et al. Economic and clinical impact of alternative disease management strategies for secondary prevention in type 2 diabetes in the Swiss setting. Schweiz Med Wochenschr 2001; 131 (21–22): 303–310 Gozzoli V, Palmer AJ, Brandt A, et al. Economic and clinical impact of alternative disease management strategies for secondary prevention in type 2 diabetes in the Swiss setting. Schweiz Med Wochenschr 2001; 131 (21–22): 303–310
26.
go back to reference Palmer AJ, Roze S, Valentine WJ, et al. Intensive lifestyle changes or metformin in patients with impaired glucose tolerance: modeling the long-term health economic implications of the diabetes prevention program in Australia, France, Germany, Switzerland, and the United Kingdom. Clin Ther 2004; 26: 304–321PubMedCrossRef Palmer AJ, Roze S, Valentine WJ, et al. Intensive lifestyle changes or metformin in patients with impaired glucose tolerance: modeling the long-term health economic implications of the diabetes prevention program in Australia, France, Germany, Switzerland, and the United Kingdom. Clin Ther 2004; 26: 304–321PubMedCrossRef
27.
go back to reference The CDC Diabetes Cost-Effectiveness Group. Cost-effectiveness of intensive glycemic control, intensified hypertension control, and serum cholesterol level reduction for type 2 diabetes. JAMA 2002; 287 (19): 2542–2551CrossRef The CDC Diabetes Cost-Effectiveness Group. Cost-effectiveness of intensive glycemic control, intensified hypertension control, and serum cholesterol level reduction for type 2 diabetes. JAMA 2002; 287 (19): 2542–2551CrossRef
28.
go back to reference Jonsson B, Cook JR, Pedersen TR. The cost-effectiveness of lipid lowering in patients with diabetes: results from the 4S trial. Diabetologia 1999; 42 (11): 1293–1301PubMedCrossRef Jonsson B, Cook JR, Pedersen TR. The cost-effectiveness of lipid lowering in patients with diabetes: results from the 4S trial. Diabetologia 1999; 42 (11): 1293–1301PubMedCrossRef
29.
go back to reference Lamotte M, Annemans L, Lefever A, et al. A health economic model to assess the long-term effects and cost-effectiveness of orlistat in obese type 2 diabetic patients. Diabetes Care 2002; 25 (2), 303–308PubMedCrossRef Lamotte M, Annemans L, Lefever A, et al. A health economic model to assess the long-term effects and cost-effectiveness of orlistat in obese type 2 diabetic patients. Diabetes Care 2002; 25 (2), 303–308PubMedCrossRef
30.
go back to reference Coyle D, Palmer AJ, Tam R. Economic evaluation of pioglitazone hydrochloride in the management of type 2 diabetes mellitus in Canada. Pharmacoeconomics 2002; 20 Suppl. 1: 31–42PubMedCrossRef Coyle D, Palmer AJ, Tam R. Economic evaluation of pioglitazone hydrochloride in the management of type 2 diabetes mellitus in Canada. Pharmacoeconomics 2002; 20 Suppl. 1: 31–42PubMedCrossRef
31.
go back to reference Eastman RC, Javitt JC, Herman WH, et al. Model of complications of NIDDM: II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of nonnoglycemia. Diabetes Care 1997; 20 (5): 735–744PubMedCrossRef Eastman RC, Javitt JC, Herman WH, et al. Model of complications of NIDDM: II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of nonnoglycemia. Diabetes Care 1997; 20 (5): 735–744PubMedCrossRef
32.
go back to reference Maetzel A, Ruof J, Covington M, et al. Economic evaluation of orlistat in overweight and obese patients with type 2 diabetes mellitus. Pharmacoeconomics 2003; 21 (7): 501–512PubMedCrossRef Maetzel A, Ruof J, Covington M, et al. Economic evaluation of orlistat in overweight and obese patients with type 2 diabetes mellitus. Pharmacoeconomics 2003; 21 (7): 501–512PubMedCrossRef
33.
go back to reference Henriksson F. Applications of economic models in healthcare: the introduction of pioglitazone in Sweden. Phannacoeconomics 2002; 20 Suppl. 1: 43–53CrossRef Henriksson F. Applications of economic models in healthcare: the introduction of pioglitazone in Sweden. Phannacoeconomics 2002; 20 Suppl. 1: 43–53CrossRef
34.
go back to reference Palmer AJ, Sendi PP, Spinas GA. Applying some UK Prospective Diabetes Study results to Switzerland: the cost-effectiveness of intensive glycaemic control with metformin versus conventional control in overweight patients with type-2 diabetes. Schweiz Med Wochenschr 2000; 130 (27–28): 1034–1040PubMed Palmer AJ, Sendi PP, Spinas GA. Applying some UK Prospective Diabetes Study results to Switzerland: the cost-effectiveness of intensive glycaemic control with metformin versus conventional control in overweight patients with type-2 diabetes. Schweiz Med Wochenschr 2000; 130 (27–28): 1034–1040PubMed
35.
go back to reference Salas M, Ward A, Caro J. Health and economic effects of adding nateglinide to metformin to achieve dual control of glycosylated hemoglobin and postprandial glucose levels in a model of type 2 diabetes mellitus. Clin Ther 2002; 24 (10): 1690–1705PubMedCrossRef Salas M, Ward A, Caro J. Health and economic effects of adding nateglinide to metformin to achieve dual control of glycosylated hemoglobin and postprandial glucose levels in a model of type 2 diabetes mellitus. Clin Ther 2002; 24 (10): 1690–1705PubMedCrossRef
36.
go back to reference Caro JJ, Klittich WS, Raggio G, et al. Economic assessment of troglitazone as an adjunct to sulfonylurea therapy in the treatment of type 2 diabetes. Clin Ther 2000; 22 (1): 116–127PubMedCrossRef Caro JJ, Klittich WS, Raggio G, et al. Economic assessment of troglitazone as an adjunct to sulfonylurea therapy in the treatment of type 2 diabetes. Clin Ther 2000; 22 (1): 116–127PubMedCrossRef
37.
go back to reference Alrmrand B, Johannesson M, Sjostrand B, et al. Cost-effectiveness of intense insulin treatment after acute myocardial infarction in patients with diabetes mellitus: results from the DIGAMI study. Eur Heart J 2000; 21 (9): 733–739CrossRef Alrmrand B, Johannesson M, Sjostrand B, et al. Cost-effectiveness of intense insulin treatment after acute myocardial infarction in patients with diabetes mellitus: results from the DIGAMI study. Eur Heart J 2000; 21 (9): 733–739CrossRef
38.
go back to reference Neeser K, Lubben G, Siebert U, et al. Cost effectiveness of combination therapy with pioglitazone for type 2 diabetes mellitus from a German statutory healthcare perspective. Pharmacoeconomics 2004; 22 (5): 321–341PubMedCrossRef Neeser K, Lubben G, Siebert U, et al. Cost effectiveness of combination therapy with pioglitazone for type 2 diabetes mellitus from a German statutory healthcare perspective. Pharmacoeconomics 2004; 22 (5): 321–341PubMedCrossRef
39.
go back to reference Casciano J, Doyle J, Casciano R, et al. The cost-effectiveness of doxazosin for the treatment of hypertension in type II diabetic patients in the UK and Italy. Int J Clin Pract 2001; 55 (2): 84–92PubMed Casciano J, Doyle J, Casciano R, et al. The cost-effectiveness of doxazosin for the treatment of hypertension in type II diabetic patients in the UK and Italy. Int J Clin Pract 2001; 55 (2): 84–92PubMed
40.
go back to reference Rodby RA, Chiou CF, Borenstein J, et al. The cost-effectiveness of irbesartan in the treatment of hypertensive patients with type 2 diabetic nephropathy. Clin Ther 2003; 25 (7): 2102–2119PubMedCrossRef Rodby RA, Chiou CF, Borenstein J, et al. The cost-effectiveness of irbesartan in the treatment of hypertensive patients with type 2 diabetic nephropathy. Clin Ther 2003; 25 (7): 2102–2119PubMedCrossRef
41.
go back to reference Grover SA, Coupal L, Zowall H, et al. How cost-effective is the treatment of dyslipidemia in patients with diabetes but without cardiovascular disease? Diabetes Care 2001; 24 (1): 45–50PubMedCrossRef Grover SA, Coupal L, Zowall H, et al. How cost-effective is the treatment of dyslipidemia in patients with diabetes but without cardiovascular disease? Diabetes Care 2001; 24 (1): 45–50PubMedCrossRef
42.
go back to reference Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group [published erratum appears in BMJ 1999 Jan 2; 318 (7175): 29]. BMJ 1998 Sep 12; 317 (7160): 703–13 Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group [published erratum appears in BMJ 1999 Jan 2; 318 (7175): 29]. BMJ 1998 Sep 12; 317 (7160): 703–13
43.
go back to reference Grimm RH, Flack JM, Grandits GA, et al. Long-term effects on plasma lipids of diet and drugs to treat hypertension. JAMA 1996; 275: 1549–1556PubMedCrossRef Grimm RH, Flack JM, Grandits GA, et al. Long-term effects on plasma lipids of diet and drugs to treat hypertension. JAMA 1996; 275: 1549–1556PubMedCrossRef
44.
go back to reference Anderson KM, Odell PM, Wilson PWF, et al. Cardiovascular disease risk profiles. Am Heart J 1990; 121: 293–298CrossRef Anderson KM, Odell PM, Wilson PWF, et al. Cardiovascular disease risk profiles. Am Heart J 1990; 121: 293–298CrossRef
45.
go back to reference UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published erratum appears in Lancet 1999 Aug 14; 354 (9178): 602]. Lancet 1998 Sep 12; 352 (9131): 837–853CrossRef UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published erratum appears in Lancet 1999 Aug 14; 354 (9178): 602]. Lancet 1998 Sep 12; 352 (9131): 837–853CrossRef
46.
go back to reference The West of Scotland Coronary Prevention Study Group. Baseline risk factors and their association with outcome in the West of Scotland Coronary Prevention Study. Am J Cardiol 1997 Mar 15; 79 (6): 756–762CrossRef The West of Scotland Coronary Prevention Study Group. Baseline risk factors and their association with outcome in the West of Scotland Coronary Prevention Study. Am J Cardiol 1997 Mar 15; 79 (6): 756–762CrossRef
47.
go back to reference Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiologic study of diabetic retinopathy: IX. Four-year incidence and progression of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1989 Feb; 107 (2): 237–243PubMedCrossRef Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiologic study of diabetic retinopathy: IX. Four-year incidence and progression of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1989 Feb; 107 (2): 237–243PubMedCrossRef
48.
go back to reference Ballard DJ, Melton LJ III, Dwyer MS, et al. Risk factors for diabetic retinopathy: a population-based study in Rochester, Minnesota. Diabetes Care 1986 Jul–Aug; 9 (4): 334–342PubMedCrossRef Ballard DJ, Melton LJ III, Dwyer MS, et al. Risk factors for diabetic retinopathy: a population-based study in Rochester, Minnesota. Diabetes Care 1986 Jul–Aug; 9 (4): 334–342PubMedCrossRef
49.
go back to reference The Diabetes Control and complications Trial Research Group. Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial [published erratum appears in JAMA 1997 Jul 2; 278 (1): 25]. JAMA 1996 Nov 6; 276 (17): 1409–1415CrossRef The Diabetes Control and complications Trial Research Group. Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial [published erratum appears in JAMA 1997 Jul 2; 278 (1): 25]. JAMA 1996 Nov 6; 276 (17): 1409–1415CrossRef
50.
go back to reference Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998; 351: 1755–1762PubMedCrossRef Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998; 351: 1755–1762PubMedCrossRef
51.
go back to reference Humphrey LL, Ballard DJ, Frohnert PP, et al. Chronic renal failure in non-insulin-dependent diabetes mellitus: a population-based study in Rochester, Minnesota. Ann Intern Med 1989 Nov 15; 111 (10): 788–796PubMed Humphrey LL, Ballard DJ, Frohnert PP, et al. Chronic renal failure in non-insulin-dependent diabetes mellitus: a population-based study in Rochester, Minnesota. Ann Intern Med 1989 Nov 15; 111 (10): 788–796PubMed
52.
go back to reference Taylor TN, Davis PH, Torner JC, et al. Lifetime cost of stroke in the United States. Stroke 1996 Sep; 27 (9): 1459–1466PubMedCrossRef Taylor TN, Davis PH, Torner JC, et al. Lifetime cost of stroke in the United States. Stroke 1996 Sep; 27 (9): 1459–1466PubMedCrossRef
53.
go back to reference Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease: part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990 Apr 7; 335 (8693): 827–838PubMedCrossRef Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease: part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990 Apr 7; 335 (8693): 827–838PubMedCrossRef
54.
go back to reference Hollander PA, Elbein SC, Hirsch IB, et al. Role of orlistat in the treatment of obese patients with type 2 diabetes: a 1-year randomized double-blind study. Diabetes Care 1998 Aug; 21 (8), 1288–1294PubMedCrossRef Hollander PA, Elbein SC, Hirsch IB, et al. Role of orlistat in the treatment of obese patients with type 2 diabetes: a 1-year randomized double-blind study. Diabetes Care 1998 Aug; 21 (8), 1288–1294PubMedCrossRef
55.
go back to reference Heymsfield SB, Segal KR, Hauptman J, et al. Fffects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med 2000 May 8; 160 (9), 1321–1326PubMedCrossRef Heymsfield SB, Segal KR, Hauptman J, et al. Fffects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med 2000 May 8; 160 (9), 1321–1326PubMedCrossRef
56.
go back to reference UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352 (9131): 854–865CrossRef UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352 (9131): 854–865CrossRef
57.
go back to reference Koskinen P, Manttari M, Manninen V, et al. Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992 Jul; 15 (7): 820–825PubMedCrossRef Koskinen P, Manttari M, Manninen V, et al. Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992 Jul; 15 (7): 820–825PubMedCrossRef
58.
go back to reference Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascularcomplications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000 Aug 12; 321 (7258): 405–412PubMedCrossRef Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascularcomplications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000 Aug 12; 321 (7258): 405–412PubMedCrossRef
59.
go back to reference Lindgarde F. The effect of orlistat on body weight and coronary heart disease risk profile in obese patients: the Swedish Multimorbidity Study. J Intern Med 2000 Sep; 248 (3): 245–254PubMedCrossRef Lindgarde F. The effect of orlistat on body weight and coronary heart disease risk profile in obese patients: the Swedish Multimorbidity Study. J Intern Med 2000 Sep; 248 (3): 245–254PubMedCrossRef
60.
go back to reference Hanefeld M, Sachse G. The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial. Diabetes Obes Metab 2002 Nov; 4 (6): 415–423PubMedCrossRef Hanefeld M, Sachse G. The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial. Diabetes Obes Metab 2002 Nov; 4 (6): 415–423PubMedCrossRef
61.
go back to reference Kelley DE, Bray GA, Pi-Sunyer FX, et al. Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: a 1-year randomized controlled trial. Diabetes Care 2002 Jun; 25 (6): 1033–1041PubMedCrossRef Kelley DE, Bray GA, Pi-Sunyer FX, et al. Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: a 1-year randomized controlled trial. Diabetes Care 2002 Jun; 25 (6): 1033–1041PubMedCrossRef
62.
go back to reference Miles JM, Leiter L, Hollander P, et al. Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metfornin. Diabetes Care 2002 Jul; 25 (7): 1123–1128PubMedCrossRef Miles JM, Leiter L, Hollander P, et al. Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metfornin. Diabetes Care 2002 Jul; 25 (7): 1123–1128PubMedCrossRef
63.
go back to reference Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin: Diabetes Prevention Program Research Group. N Engl J Med 2002 Feb 7; 346 (6): 393–403PubMedCrossRef Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin: Diabetes Prevention Program Research Group. N Engl J Med 2002 Feb 7; 346 (6): 393–403PubMedCrossRef
64.
go back to reference Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes: Collaborative Study Group. N Engl J Med 2001 Sep 20; 345 (12): 851–860PubMedCrossRef Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes: Collaborative Study Group. N Engl J Med 2001 Sep 20; 345 (12): 851–860PubMedCrossRef
65.
go back to reference Rodby RA, Rohde RD, Clarke WR, et al. The Irbesartan type II diabetic nephropathy trial: study design and baseline patient characteristics. For the Collaborative Study Group. Nephrol Dial Transplant 2000 Apr; 15 (4): 487–497PubMedCrossRef Rodby RA, Rohde RD, Clarke WR, et al. The Irbesartan type II diabetic nephropathy trial: study design and baseline patient characteristics. For the Collaborative Study Group. Nephrol Dial Transplant 2000 Apr; 15 (4): 487–497PubMedCrossRef
66.
go back to reference Balkau B, Eschwege E, Papoz L, et al. Risk factors for early death in non-insulin dependent diabetes and men with known glucose tolerance status. BMJ 1993; 307 (6899): 295–299PubMedCrossRef Balkau B, Eschwege E, Papoz L, et al. Risk factors for early death in non-insulin dependent diabetes and men with known glucose tolerance status. BMJ 1993; 307 (6899): 295–299PubMedCrossRef
67.
go back to reference Panzram G. Mortality and survival in type 2 (non-insulin-dependent) diabetes mellitus [published erratum appears in Diabetologia 1987; 30 (5): 364]. Diabetologia 1987; 30 (3): 123–131PubMedCrossRef Panzram G. Mortality and survival in type 2 (non-insulin-dependent) diabetes mellitus [published erratum appears in Diabetologia 1987; 30 (5): 364]. Diabetologia 1987; 30 (3): 123–131PubMedCrossRef
68.
go back to reference Simons LA, McCallum J, Freidlander Y, et al. Diabetes, mortality and coronary heart disease in the prospective Dubbo study of Australian elderly. Aust N Z J Med 1996; 26 (1): 66–74PubMedCrossRef Simons LA, McCallum J, Freidlander Y, et al. Diabetes, mortality and coronary heart disease in the prospective Dubbo study of Australian elderly. Aust N Z J Med 1996; 26 (1): 66–74PubMedCrossRef
69.
go back to reference Drenick EJ, Bale GS, Seltzer F, et al. Excessive mortality and causes of death in morbidly obese men. JAMA 1980; 243 (5): 443–445PubMedCrossRef Drenick EJ, Bale GS, Seltzer F, et al. Excessive mortality and causes of death in morbidly obese men. JAMA 1980; 243 (5): 443–445PubMedCrossRef
70.
go back to reference Manson JE, Stampfer MJ, Hennekens CH, et al. Body weight and longevity: a reassessment. JAMA 1987; 257 (3): 353–358PubMedCrossRef Manson JE, Stampfer MJ, Hennekens CH, et al. Body weight and longevity: a reassessment. JAMA 1987; 257 (3): 353–358PubMedCrossRef
71.
go back to reference Rissanen A, Heliovaara M, P Knekt, et al. Risk of disability and mortality due to overweight in a Finnish population. BMJ 1990; 301 (6756): 835–837PubMedCrossRef Rissanen A, Heliovaara M, P Knekt, et al. Risk of disability and mortality due to overweight in a Finnish population. BMJ 1990; 301 (6756): 835–837PubMedCrossRef
72.
go back to reference Body weight and mortality: a 27-year follow-up of middle aged men. JAMA 1993; 270 (23): 2823–8 Body weight and mortality: a 27-year follow-up of middle aged men. JAMA 1993; 270 (23): 2823–8
73.
go back to reference Eriksson KF, Lindgarde F. Prevention of type 2 (non-insulindependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study. Diabetologia 1991 Dec; 34 (12), 891–898PubMedCrossRef Eriksson KF, Lindgarde F. Prevention of type 2 (non-insulindependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study. Diabetologia 1991 Dec; 34 (12), 891–898PubMedCrossRef
74.
go back to reference Australian Bureau of Statistics (1995). Deaths, Australia (1994). Catalogue No. 3302.0. Australian Government Publishing Service, Canberra Australian Bureau of Statistics (1995). Deaths, Australia (1994). Catalogue No. 3302.0. Australian Government Publishing Service, Canberra
75.
go back to reference Haffner SM, Alexander CM, Cook TJ, et al. Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study. Arch Intern Med 1999 Dec 13–27; 159 (22): 2661–2667PubMedCrossRef Haffner SM, Alexander CM, Cook TJ, et al. Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study. Arch Intern Med 1999 Dec 13–27; 159 (22): 2661–2667PubMedCrossRef
76.
go back to reference Grover SA, Coupal L, Paquet S, et al. Cost-effectiveness of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the secondary prevention of cardiovascular disease: forecasting the incremental benefits of preventing coronary and cerebrovascular events. Arch Intern Med 1999 Mar 22; 159 (6): 593–600PubMedCrossRef Grover SA, Coupal L, Paquet S, et al. Cost-effectiveness of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the secondary prevention of cardiovascular disease: forecasting the incremental benefits of preventing coronary and cerebrovascular events. Arch Intern Med 1999 Mar 22; 159 (6): 593–600PubMedCrossRef
77.
go back to reference Grover SA, Paquet S, Levinton C, et al. Estimating the benefits of modifying risk factors of cardiovascular disease: a comparison of primary vs secondary prevention. Arch Intern Med 1998 Mar 23; 158 (6): 655–662PubMedCrossRef Grover SA, Paquet S, Levinton C, et al. Estimating the benefits of modifying risk factors of cardiovascular disease: a comparison of primary vs secondary prevention. Arch Intern Med 1998 Mar 23; 158 (6): 655–662PubMedCrossRef
78.
go back to reference Grover SA, Palmer CS, Coupal L. Serum lipid screening to identify high-risk individuals for coronary death: the results of the Lipid Research Clinics prevalence cohort. Arch Intern Med 1994 Mar 28; 154 (6): 679–684PubMedCrossRef Grover SA, Palmer CS, Coupal L. Serum lipid screening to identify high-risk individuals for coronary death: the results of the Lipid Research Clinics prevalence cohort. Arch Intern Med 1994 Mar 28; 154 (6): 679–684PubMedCrossRef
79.
go back to reference Horton ES, Clinkingbeard C, Gatlin M, et al. Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes. Diabetes Care 2000 Nov; 23 (11): 1660–1665PubMedCrossRef Horton ES, Clinkingbeard C, Gatlin M, et al. Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes. Diabetes Care 2000 Nov; 23 (11): 1660–1665PubMedCrossRef
80.
go back to reference The Diabetes Control and complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N Engl J Med 1993 Sep 30; 329 (14), 977–986CrossRef The Diabetes Control and complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N Engl J Med 1993 Sep 30; 329 (14), 977–986CrossRef
81.
go back to reference Horton ES, Whitehouse F, Ghazzi MN, et al. Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes: the Troglitazone Study Group. Diabetes Care 1998 Sep; 21 (9): 1462–1469PubMedCrossRef Horton ES, Whitehouse F, Ghazzi MN, et al. Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes: the Troglitazone Study Group. Diabetes Care 1998 Sep; 21 (9): 1462–1469PubMedCrossRef
82.
go back to reference Palmer AJ, Weiss C, Sendi PP, et al. The cost-effectiveness of different management strategies for type I diabetes: a Swiss perspective. Diabetologia 2000 Jan; 43 (1): 13–26PubMedCrossRef Palmer AJ, Weiss C, Sendi PP, et al. The cost-effectiveness of different management strategies for type I diabetes: a Swiss perspective. Diabetologia 2000 Jan; 43 (1): 13–26PubMedCrossRef
83.
go back to reference Aronoff S, Rosenblatt S, Braithwaite S, et al. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group. Diabetes Care 2000 Nov; 23 (11): 1605–1611PubMedCrossRef Aronoff S, Rosenblatt S, Braithwaite S, et al. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group. Diabetes Care 2000 Nov; 23 (11): 1605–1611PubMedCrossRef
84.
go back to reference Johansen K. Efficacy of metformin in the treatment of NIDDM: meta-analysis. Diabetes Care 1999 Jan; 22 (1): 33–37PubMedCrossRef Johansen K. Efficacy of metformin in the treatment of NIDDM: meta-analysis. Diabetes Care 1999 Jan; 22 (1): 33–37PubMedCrossRef
85.
go back to reference Hermann LS, Schersten B, Bitzen PO, et al. Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations: a double-blind controlled study. Diabetes Care 1994 Oct; 17 (10): 1100–1109PubMedCrossRef Hermann LS, Schersten B, Bitzen PO, et al. Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations: a double-blind controlled study. Diabetes Care 1994 Oct; 17 (10): 1100–1109PubMedCrossRef
86.
go back to reference Matthews DR, Cull CA, Stratton IM, et al. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) group. Diabet Med 1998 Apr; 15 (4): 297–303PubMedCrossRef Matthews DR, Cull CA, Stratton IM, et al. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) group. Diabet Med 1998 Apr; 15 (4): 297–303PubMedCrossRef
87.
go back to reference Henriksson F, Agardh CD, Berne C, et al. Direct medical costs for patients with type 2 diabetes in Sweden. J Intern Med 2000 Nov; 248 (5): 387–396PubMedCrossRef Henriksson F, Agardh CD, Berne C, et al. Direct medical costs for patients with type 2 diabetes in Sweden. J Intern Med 2000 Nov; 248 (5): 387–396PubMedCrossRef
88.
go back to reference UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998 Sep 12; 317 (7160): 713–720CrossRef UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998 Sep 12; 317 (7160): 713–720CrossRef
89.
go back to reference Bundesamt fur Statistik. Stebetafeln fur die Schweiz 1988/1993. Bern: 1996 Bundesamt fur Statistik. Stebetafeln fur die Schweiz 1988/1993. Bern: 1996
90.
go back to reference Arbeitsgruppe der Schweizerischen Diabetes-Stiftung. Die St. Vincent-Deklaration: eine Umfrage zur Diabetiker-Betreuung in der Schweiz. Schweizerische Aerztezeitung 1996; 77: 668–675 Arbeitsgruppe der Schweizerischen Diabetes-Stiftung. Die St. Vincent-Deklaration: eine Umfrage zur Diabetiker-Betreuung in der Schweiz. Schweizerische Aerztezeitung 1996; 77: 668–675
91.
go back to reference Kipnes MS, Krosnick A, Rendell MS, et al. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. Am J Med 2001 Jul; 111 (1): 10–17PubMedCrossRef Kipnes MS, Krosnick A, Rendell MS, et al. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. Am J Med 2001 Jul; 111 (1): 10–17PubMedCrossRef
92.
go back to reference Einhorn D, Rendell M, Rosenzweig J, et al. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group. Clin Ther 2000 Dec; 22 (12): 1395–1409PubMedCrossRef Einhorn D, Rendell M, Rosenzweig J, et al. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group. Clin Ther 2000 Dec; 22 (12): 1395–1409PubMedCrossRef
93.
go back to reference Piehlmeier W, Renner R, Schramm W, et al. Screening of diabetic patients for microalbuminuria in primary care: the PROSIT-Project. Proteinuria Screening and Intervention. Exp Clin Endocrinol Diabetes 1999; 107 (4): 244–251PubMedCrossRef Piehlmeier W, Renner R, Schramm W, et al. Screening of diabetic patients for microalbuminuria in primary care: the PROSIT-Project. Proteinuria Screening and Intervention. Exp Clin Endocrinol Diabetes 1999; 107 (4): 244–251PubMedCrossRef
94.
go back to reference Malrrberg K, Ryden L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995 Jul; 26 (1): 57–65CrossRef Malrrberg K, Ryden L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995 Jul; 26 (1): 57–65CrossRef
95.
go back to reference Malrrberg K. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) study group. BMJ 1997 May 24; 314 (7093): 1512–1515CrossRef Malrrberg K. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) study group. BMJ 1997 May 24; 314 (7093): 1512–1515CrossRef
96.
go back to reference CDC Diabetes Cost-Effectiveness Study Group. The cost-effectiveness of screening for type 2 diabetes. JAMA 1998; 280 (20): 1757–1763CrossRef CDC Diabetes Cost-Effectiveness Study Group. The cost-effectiveness of screening for type 2 diabetes. JAMA 1998; 280 (20): 1757–1763CrossRef
97.
go back to reference Welte R, Feenstra T, Jager H, et al. A decision chart for assessing and improving the transferability of economic results between countries. Pharmacoeconomics 2004; 22 (13): 857–876PubMedCrossRef Welte R, Feenstra T, Jager H, et al. A decision chart for assessing and improving the transferability of economic results between countries. Pharmacoeconomics 2004; 22 (13): 857–876PubMedCrossRef
Metadata
Title
Cost Effectiveness of Preventive Interventions in Type 2 Diabetes Mellitus
A Systematic Literature Review
Authors
Sylvia M. C. Vijgen
Mirjam Hoogendoorn
Caroline A. Baan
G. Ardine de Wit
Wien Limburg
Talitha L. Feenstra
Publication date
01-05-2006
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 5/2006
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200624050-00002

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