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PharmacoEconomics
Published in: PharmacoEconomics 7/2001

01-07-2001 | Review Article

A Clinical and Economic Review of Disease-Modifying Antirheumatic Drugs

Authors: Dr Sherine E. Gabriel, Douglas Coyle, Larry W. Moreland

Published in: PharmacoEconomics | Issue 7/2001

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Abstract

Rheumatoid arthritis is one of the most common chronic systemic inflammatory diseases, affecting approximately 1% of the adult population. Disease-modifying antirheumatic drugs (DMARDs) have been the mainstay of treatment for rheumatoid arthritis when combinedwith physical therapy and aspirin (acetylsalicylic acid) or nonsteroidal anti-inflammatory drugs. Recently, a number of new biological therapies have been introduced for the treatment of this condition and will have a major impact on the future management of this disabling disease. In this review, we summarise data on the efficacy and tolerability of the currently available DMARDs, including gold compounds, antimalarials, penicillamine, cytotoxic drugs (azathioprine and cyclophosphamide), sulfasalazine, methotrexate, leflunomide, cyclosporin, anti-tumour necrosis factor agents, combination therapy and apheresis. A literature review and quality assessment of economic evaluations of DMARDs is presented, illustrating that there has been a paucity of economic evaluations on these agents and showing the variable quality of those studies that are available. The manuscript also addresses the pharmacoeconomic implications of the new agents for rheumatoid arthritis; the need for formal long term economic evaluations in order to determine the cost effectiveness of these costly, but highly effective, new treatments is emphasised.
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Metadata
Title
A Clinical and Economic Review of Disease-Modifying Antirheumatic Drugs
Authors
Dr Sherine E. Gabriel
Douglas Coyle
Larry W. Moreland
Publication date
01-07-2001
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 7/2001
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200119070-00002

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