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01-12-2007 | Adis Drug Profile

Trastuzumab

In HER2 and Hormone Receptor Co-Positive Metastatic Breast Cancer

Authors: Jennifer S. Orman, Caroline M. Perry

Published in: Drugs | Issue 18/2007

Abstract

▲ Trastuzumab is a humanised IgG₁ monoclonal antibody, which selectively binds to the human epidermal growth factor receptor 2 (HER2), inhibiting cell proliferation and survival in HER2-dependent tumours.
▲ In a randomised phase III trial in postmenopausal women with HER2 and hormone receptor (HR) copositive metastatic breast cancer, median progression-free survival (primary endpoint) was significantly longer in patients receiving intravenous trastuzumab plus oral anastrozole than in those receiving anastrozole alone.
▲ Overall response rate and clinical benefit rate were also significantly higher, and median time to disease progression was significantly longer with trastuzumab plus anastrozole versus anastrozole alone.
▲ There were no reports of new or unexpected adverse events with trastuzumab plus anastrozole combination therapy in the randomised phase III trial.
▲ In a noncomparative phase II study of trastuzumab plus letrozole in postmenopausal women with HER2 and HR co-positive metastatic breast cancer, the majority of adverse events were mild or moderate in severity.

The use of trade names is for product identification purposes only and does not imply endorsement.

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Title: Trastuzumab
In HER2 and Hormone Receptor Co-Positive Metastatic Breast Cancer
Authors: Jennifer S. Orman
Caroline M. Perry
Publication date: 01-12-2007
Publisher: Springer International Publishing
Published in: Drugs / Issue 18/2007
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.2165/00003495-200767180-00009

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Trastuzumab

In HER2 and Hormone Receptor Co-Positive Metastatic Breast Cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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