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01-02-2004 | Adis Drug Profile

Daptomycin

Authors: Caroline Fenton, Caroline Fenton, Gillian M. Keating, Monique P. Curran

Published in: Drugs | Issue 4/2004

Abstract

▴ Daptomycin is a lipopeptide antibacterial with rapid in vitro activity against Gram-positive cocci. It is approved for use in patients with complicated skin and skin structure infections (cSSSIs) caused by specified Gram-positive cocci.
▴ In vitro, daptomycin was active against Staphylococcus aureus (including meticillin-resistantstrains), Streptococcus pyogenes, S. agalactiae, group C and G β-haemolytic streptococci and vancomycin-susceptible Enterococcus faecalis. Bactericidal activity in vitro was rapid and concentration dependent.
▴ In two randomised, investigator-blinded, multicentre trials in patients with cSSSIs, intravenous daptomycin 4 mg/kg once daily was as effective as standard therapy (intravenous semi-synthetic penicillin 4–12 g/day or vancomycin 1g 12-hourly). Clinical success rates assessed 6–20 days after treatment end were 82.1% in daptomycin recipients and 82.9% in recipients of standard therapy (pooled data).
▴ In patients with cSSSIs, the adverse event profiles of daptomycin and vancomycin were similar. Creatine phosphokinase (CPK) levels increased in 2.8% of daptomycin recipients and 1.8% of patients who received standard therapy; only one daptomycin recipient (0.2%) experienced increased CPK levels and muscle symptoms that were not associated with any comorbid factors.

Use of tradenames is for product identification purposes only and does not imply endorsement.

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Title: Daptomycin
Authors: Caroline Fenton
Caroline Fenton
Gillian M. Keating
Monique P. Curran
Publication date: 01-02-2004
Publisher: Springer International Publishing
Published in: Drugs / Issue 4/2004
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.2165/00003495-200464040-00009

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Daptomycin

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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