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01-06-2000 | Leading Article

An ABC of Drug-Related Problems

Authors: Dr Ronald H.B. Meyboom, Marie Lindquist, Antoine C.G. Egberts

Published in: Drug Safety | Issue 6/2000

Abstract

The problems relating to the use of medicines are manifold. They may differ in pharmacological, pathological, epidemiological and legal respects, and may have different consequences, for example, as regards scientific study, regulation or rational use. Pharmacovigilance is concerned with all such problems: adverse effects and interactions as well as problems relating to ineffectiveness, inappropriate use, counterfeiting, dependence or poisoning.

Practically all medicine-related problems can be classified in one basic system, taking into account their characteristics and distinctions. This system distinguishes between appropriate and inappropriate drug use, dose-related and dose-unrelated problems, and types A (‘drug actions’), B (‘patient reactions’) and C (‘statistical’) adverse effects. This classification may serve as an educational tool and may be useful in when choosing a study method and for the design of effective strategies in pharmacovigilance.

Drug Monitoring. The role of the hospital. WHO Technical Report Series 425. World Health Organization, Geneva, Switzerland, 1969

Edwards IR, Biriell C. Harmonisation in pharmacovigilance. Drug Saf 1994; 10: 93–102PubMedCrossRef

Nelson KM, Talbert RL. Drug-related hospital admissions. Pharmacotherapy 1996; 16: 701–7PubMed

Imbs JL. Pouyanne P, Haramburu F, et al. Iatrogenie médicamenteuse: estimation de sa prévalance dans les hôpitaux publics français. Thérapie 1999; 34: 21–7

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients. JAMA 1998; 279: 1200–5PubMedCrossRef

Rawlins MD, Thompson JW. Mechanisms of adverse drug reactions. In: Davies DM, editor. Textbook of adverse drug reactions. IVth ed. Oxford: Oxford University Press, 1991: 18–45

Inman WHW, editor. Monitoring for drug safety. 2nd ed. Lancaster: MTP Press, 1986

Royer RJ. Mechanism of action of adverse drug reactions: an overview. Pharmacoepidemiol Drug Saf 1997; Suppl. 3: S43–S50CrossRef

Meyboom RHB, Egberts ACG, Edwards IR, et al. Principles of signal detection in pharmacovigilance. Drug Saf 1997; 16: 355–65PubMedCrossRef

10.

Dukes MNG, editor. Meyler’s side effects of drugs. 13th ed. Amsterdam: Elsevier Science Publishers, 1996

11.

Meyboom RHB, Gribnau FWJ, Hekster YA, et al. Characteristics of topics in pharmacovigilance in the Netherlands. Clin Drug Invest 1996; 4: 207–19

12.

Strom BL, editor. Pharmacoepidemiology. 2nd ed. Chichester: John Wiley & Sons, 1994

13.

The committee for the assessment of the biometric aspects of controlled trials of hypoglycaemic agents. Special Report. JAMA 1975; 213: 583

14.

Committee of Principle Investigators. Acooperative trial in the primary prevention of ischaemic heart disease using clofibrate. Br Heart J 1978; 40: 1069

15.

Kimura K. WHO Data Base on Counterfeit Pharmaceuticals. World Health Organization, Geneva, 1998

16.

Counterfeit Drugs. Guidelines for the development of measures to combat counterfeit drugs. Department of Essential Drugs and Other Medicines. World Health Organization, Geneva, Switzerland, 1999

17.

Conroy S, Choonara I, Impicciatore P, et al. Survey of unlicensed and off label drug use in paediatric wards in European countries. BMJ 2000; 320: 79–82PubMedCrossRef

18.

Phillips DP, Christenfeld N, Glynn LM. Increase in US medication-error deaths between 1983-1993. Lancet 1997; 351: 643–4CrossRef

19.

Kohn LT, Corrigan JM, Donaldson MS, editors. To err is human. Building a safer health system. Committee on Quality of Health Care in America. National Academy Press, Washington DC, 1999

20.

Medawar C. The antidepressant web. Int J Risk Saf Med 1997; 10: 75–127

21.

De Broe ME, Elseviers MM. Analgesic nephropathy. N Engl J Med 1998; 338: 446–52PubMedCrossRef

Title: An ABC of Drug-Related Problems
Authors: Dr Ronald H.B. Meyboom
Marie Lindquist
Antoine C.G. Egberts
Publication date: 01-06-2000
Publisher: Springer International Publishing
Published in: Drug Safety / Issue 6/2000
Print ISSN: 0114-5916
Electronic ISSN: 1179-1942
DOI: https://doi.org/10.2165/00002018-200022060-00001

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An ABC of Drug-Related Problems

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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