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Published in: Annals of Surgical Oncology 5/2023

06-02-2023 | Cytostatic Therapy | Peritoneal Surface Malignancy

Evaluating End Points of the Efficacy of Intraperitoneal Chemotherapy Techniques Including PIPAC

Authors: Kevin M. Sullivan, MD, Mustafa Raoof, MD

Published in: Annals of Surgical Oncology | Issue 5/2023

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Excerpt

Peritoneal metastases (PM) are challenging to treat, with progressive disease resulting in significant detriments to both quality of life and survival for patients. Currently, two accepted treatment methods for PM are available: systemic chemotherapy and cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC). For patients who are not candidates to receive CRS with or without HIPEC, pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel method for delivering repeatable intraperitoneal (IP) chemotherapy as a minimally invasive laparoscopic procedure. …
Literature
2.
go back to reference Tempfer CB, Winnekendonk G, Solass W, Horvat R, Giger-Pabst U, Zieren J, et al. Pressurized intraperitoneal aerosol chemotherapy in women with recurrent ovarian cancer: a phase 2 study. Gynecol Oncol. 2015;137:223–8.CrossRefPubMed Tempfer CB, Winnekendonk G, Solass W, Horvat R, Giger-Pabst U, Zieren J, et al. Pressurized intraperitoneal aerosol chemotherapy in women with recurrent ovarian cancer: a phase 2 study. Gynecol Oncol. 2015;137:223–8.CrossRefPubMed
3.
go back to reference Struller F, Horvath P, Solass W, Weinreich FJ, Strumberg D, Kokkalis MK, et al. Pressurized intraperitoneal aerosol chemotherapy with low-dose cisplatin and doxorubicin (PIPAC C/D) in patients with gastric cancer and peritoneal metastasis: a phase II study. Ther Adv Med Oncol. 2019;11:1758835919846402.CrossRefPubMedPubMedCentral Struller F, Horvath P, Solass W, Weinreich FJ, Strumberg D, Kokkalis MK, et al. Pressurized intraperitoneal aerosol chemotherapy with low-dose cisplatin and doxorubicin (PIPAC C/D) in patients with gastric cancer and peritoneal metastasis: a phase II study. Ther Adv Med Oncol. 2019;11:1758835919846402.CrossRefPubMedPubMedCentral
4.
go back to reference Khomyakov V, Ryabov A, Ivanov A, Bolotina L, Utkina A, Volchenko N, et al. Bidirectional chemotherapy in gastric cancer with peritoneal metastasis combining intravenous XELOX with intraperitoneal chemotherapy with low-dose cisplatin and doxorubicin administered as a pressurized aerosol: an open-label, phase-2 study (PIPAC-GA2). Pleura Peritoneum. 2016;1:159–66.CrossRefPubMedPubMedCentral Khomyakov V, Ryabov A, Ivanov A, Bolotina L, Utkina A, Volchenko N, et al. Bidirectional chemotherapy in gastric cancer with peritoneal metastasis combining intravenous XELOX with intraperitoneal chemotherapy with low-dose cisplatin and doxorubicin administered as a pressurized aerosol: an open-label, phase-2 study (PIPAC-GA2). Pleura Peritoneum. 2016;1:159–66.CrossRefPubMedPubMedCentral
5.
go back to reference Graversen M, Detlefsen S, Bjerregaard JK, Fristrup CW, Pfeiffer P, Mortensen MB, et al. Prospective, single-center implementation and response evaluation of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastasis. Ther Adv Med Oncol. 2018;10:1758835918777036.CrossRefPubMedPubMedCentral Graversen M, Detlefsen S, Bjerregaard JK, Fristrup CW, Pfeiffer P, Mortensen MB, et al. Prospective, single-center implementation and response evaluation of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastasis. Ther Adv Med Oncol. 2018;10:1758835918777036.CrossRefPubMedPubMedCentral
6.
go back to reference Dumont F, Passot C, Raoul JL, Kepenekian V, Lelièvre B, Boisdron-Celle M, et al. A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers. Eur J Cancer. 2020;140:37–44.CrossRefPubMed Dumont F, Passot C, Raoul JL, Kepenekian V, Lelièvre B, Boisdron-Celle M, et al. A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers. Eur J Cancer. 2020;140:37–44.CrossRefPubMed
7.
go back to reference Kim G, Tan HL, Sundar R, Lieske B, Chee CE, Ho J, et al. PIPAC-OX: a phase I study of oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy in patients with peritoneal metastases. Clin Cancer Res. 2021;27:1875–81.CrossRefPubMed Kim G, Tan HL, Sundar R, Lieske B, Chee CE, Ho J, et al. PIPAC-OX: a phase I study of oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy in patients with peritoneal metastases. Clin Cancer Res. 2021;27:1875–81.CrossRefPubMed
8.
go back to reference Rovers KP, Wassenaar EC, Lurvink RJ, Creemers GJ, Burger JW, Los M, et al. Pressurized Intraperitoneal aerosol chemotherapy (oxaliplatin) for unresectable colorectal peritoneal metastases: a multicenter, single-arm, phase II trial (CRC-PIPAC). Ann Surg Oncol. 2021;28:5311–26.CrossRefPubMed Rovers KP, Wassenaar EC, Lurvink RJ, Creemers GJ, Burger JW, Los M, et al. Pressurized Intraperitoneal aerosol chemotherapy (oxaliplatin) for unresectable colorectal peritoneal metastases: a multicenter, single-arm, phase II trial (CRC-PIPAC). Ann Surg Oncol. 2021;28:5311–26.CrossRefPubMed
9.
go back to reference Robella M, De Simone M, Berchialla P, Argenziano M, Borsano A, Ansari S, et al. A phase I dose escalation study of oxaliplatin, cisplatin, and doxorubicin applied as PIPAC in patients with peritoneal carcinomatosis. Cancers Basel. 2021;13:1060.CrossRefPubMedPubMedCentral Robella M, De Simone M, Berchialla P, Argenziano M, Borsano A, Ansari S, et al. A phase I dose escalation study of oxaliplatin, cisplatin, and doxorubicin applied as PIPAC in patients with peritoneal carcinomatosis. Cancers Basel. 2021;13:1060.CrossRefPubMedPubMedCentral
Metadata
Title
Evaluating End Points of the Efficacy of Intraperitoneal Chemotherapy Techniques Including PIPAC
Authors
Kevin M. Sullivan, MD
Mustafa Raoof, MD
Publication date
06-02-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 5/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-13124-z

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