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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2022

20-09-2022 | Mastectomy | ASO Author Reflections

ASO Author Reflections: Is Breast-Conserving Surgery a Safe Treatment Option for High-Risk Breast Cancer?

Authors: Francesca Magnoni, MD, PhD, Giovanni Corso, MD, PhD

Published in: Annals of Surgical Oncology | Issue 13/2022

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Excerpt

After the identification of BRCA genes in the early 1990s, scientific research has ascertained the enhanced inherited susceptibility for breast cancer (BC), intrinsically linked to mutations in these genes. Indeed, an elevated risk of both local recurrence, ipsilateral to the index tumor, and subsequent contralateral cancer has been recognized in BC patients carrying germline high-risk pathogenic variant mutations.1 Furthermore, a very high risk of development of a first new BC diagnosis in asymptomatic individuals has been reported.2 Surgical preventive managing of such typology of women has evolved accordingly, based on international scientific guidelines,2 consolidating the predominant role of bilateral mastectomy, very frequently used and considered the only life-saving option. …
Literature
1.
Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips KA, Mooij TM, Roos- Blom MJ, et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402–16.CrossRefPubMed
2.
Corso G, Robson ME, Sacchini V. Points to consider regarding risk-reducing mastectomy in high-, moderate-, and low-penetrance gene carriers. Ann Surg Oncol. 2022;29(9):5821–5.CrossRefPubMed
3.
4.
Magnoni F, Sacchini V, Veronesi P, et al. Surgical management of inherited breast cancer: role of breast-conserving surgery. Cancers (Basel). 2022;14(13):3245.CrossRefPubMedPubMedCentral
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Morrow M. Surgery and prophylactic surgery in hereditary breast cancer. Breast. 2022;62(Suppl 1):S63–6.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Is Breast-Conserving Surgery a Safe Treatment Option for High-Risk Breast Cancer?
Authors
Francesca Magnoni, MD, PhD
Giovanni Corso, MD, PhD
Publication date
20-09-2022
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-022-12589-8

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