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06-08-2022 | Ultrasound | ASO Author Reflections

ASO Author Reflections: Management of the Lymph Node Basin in Cutaneous Melanoma—Patterns of Completion Dissection in a National Cohort

Authors: Cimarron E. Sharon, MD, Giorgos C. Karakousis, MD, John T. Miura, MD

Published in: Annals of Surgical Oncology | Issue 13/2022

Excerpt

The German Dermatologic Cooperative Oncology Group-Selective Lymphadenectomy Trial (DeCOG-SLT)¹ and the second Multicenter and Selective Lymphadenectomy Trial (MSLT-II)² demonstrated that, for patients with cutaneous melanoma with sentinel lymph node (SLN) metastases, nodal observation with serial ultrasounds is a safe alternative to completion lymph node dissection (CLND). These landmark clinical trials identified no differences in overall survival or disease-specific survival between patients who underwent CLND compared with ultrasound surveillance. As such, there has been a near-universal shift in practice paradigm from CLND to nodal surveillance in these patients, although national patterns remain poorly characterized. …

Leiter U, Stadler R, Mauch C, et al. Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol. 2016;17(6):757–67. https://doi.org/10.1016/S1470-2045(16)00141-8.CrossRefPubMed

Faries MB, Thompson JF, Cochran AJ, et al. Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med. 2017;376(23):2211–2222. https://doi.org/10.1056/NEJMoa1613210.

Sharon C, Straker RI, Li E, Karakousis G, Miura J. National practice patterns in the management of the regional lymph node basin following positive sentinel lymph node biopsy for cutaneous melanoma. Ann Surg Oncol. 2022. https://doi.org/10.1245/s10434-022-12364-9.

Bredbeck BC, Mubarak E, Zubieta DG, et al. Management of the positive sentinel lymph node in the post-MSLT-II era. J Surg Oncol. 2020;122(8):1778–84. https://doi.org/10.1002/jso.26200.CrossRefPubMedPubMedCentral

Nijhuis AAG, Spillane AJ, Stretch JR, et al. Current management of patients with melanoma who are found to be sentinel node-positive. ANZ J Surg. 2020;90(4):491–6. https://doi.org/10.1111/ans.15491.CrossRefPubMed

Title: ASO Author Reflections: Management of the Lymph Node Basin in Cutaneous Melanoma—Patterns of Completion Dissection in a National Cohort
Authors: Cimarron E. Sharon, MD
Giorgos C. Karakousis, MD
John T. Miura, MD
Publication date: 06-08-2022
Publisher: Springer International Publishing
Keywords: Ultrasound
Melanoma
Melanoma
Head and Neck Cancer
Ultrasound
Lymphadenectomy
Published in: Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-022-12373-8

At a glance: The STEP trials

Springer Medicine

ASO Author Reflections: Management of the Lymph Node Basin in Cutaneous Melanoma—Patterns of Completion Dissection in a National Cohort

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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