Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2022

16-08-2022 | Mastectomy | ASO Author Reflections

ASO Author Reflections: Avoiding Overtreatment: Benefits of Selective Use of Frozen Sections Among cN0 Breast Cancer Patients Having Upfront Mastectomy

Authors: Austin D. Williams, MD, MSEd, Anita Mamtani, MD

Published in: Annals of Surgical Oncology | Issue 13/2022

Login to get access

Excerpt

The AMAROS and OTOASOR trials have demonstrated that axillary radiotherapy is associated with equivalent outcomes when compared with axillary lymph node dissection (ALND) among clinically node-negative (cN0) patients with one to two positive sentinel lymph nodes (SLNs) who undergo upfront surgery.1,2 Traditionally, ALND has been performed for any SLN macrometastasis identified in patients undergoing upfront mastectomy, although in patients with limited nodal disease for whom postmastectomy radiation and regional nodal irradiation (PMRT) is indicated, ALND may be omitted. In the absence of consensus guidelines, it has been challenging to identify patients who will require PMRT, leading to substantial overtreatment with ALND+PMRT, which is associated with a significantly increased risk of lymphedema.2 …
Literature
1.
Donker M, van Tienhoven G, Straver ME, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981–22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15(12):1303–10.CrossRefPubMedPubMedCentral
2.
Sávolt Á, Péley G, Polgár C, et al. Eight-year follow up result of the OTOASOR trial: the optimal treatment of the Axilla—Surgery Or Radiotherapy after positive sentinel lymph node biopsy in early-stage breast cancer: a randomized, single centre, phase III, non-inferiority trial. Eur J Surg Oncol. 2017;43(4):672–9.CrossRefPubMed
3.
Metadata
Title
ASO Author Reflections: Avoiding Overtreatment: Benefits of Selective Use of Frozen Sections Among cN0 Breast Cancer Patients Having Upfront Mastectomy
Authors
Austin D. Williams, MD, MSEd
Anita Mamtani, MD
Publication date
16-08-2022
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-022-12333-2

Other articles of this Issue 13/2022

Annals of Surgical Oncology 13/2022 Go to the issue

Thoracic Oncology

Radiomics with Artificial Intelligence for the Prediction of Early Recurrence in Patients with Clinical Stage IA Lung Cancer

ASO Visual Abstract

ASO Visual Abstract: Impact of Textbook Oncologic Outcome Attainment on Survival Following Gastrectomy: A Review of the National Cancer Database

Global Health Services Research

Decreasing Medicare Reimbursements for Surgical Oncology Procedures: Future Implications

Pancreatic Tumors

The Impact of Carbohydrate Antigen 19-9 on Survival in Patients with Clinical Stage I and II Pancreatic Cancer

ASO Author Reflections

ASO Author Reflections: Challenges in the Management of Bowel Obstruction after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy

ASO Author Reflections

ASO Author Reflections: Investigating the Relationship Between Patient Primary Language and Surgical Oncology Outcomes