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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2022

03-10-2022 | Metastasis | ASO Author Reflections

ASO Author Reflections: Combination Intra-Peritoneal and Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastases

Authors: Daryl K. A. Chia, FRCS, Jia Jun Ang, MRCS, Raghav Sundar, MRCP, Guowei Kim, FRCS, Asim Shabbir, FRCS, Jimmy B. Y. So, MPH, FRCS, Wei Peng Yong, MRCP

Published in: Annals of Surgical Oncology | Issue 13/2022

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Excerpt

Past Gastric cancer with peritoneal metastases (GCPM) portends a poor prognosis. Despite initial promising results of neoadjuvant intra-peritoneal and systemic (NIPS) chemotherapy trials, the only phase III randomized controlled trial to date (PHOENIX-GC) reported a survival benefit with IP paclitaxel (PTX), systemic paclitaxel + S-1 but did not reach statistical significance.1 There are otherwise few comparative studies reporting the outcomes of NIPS for GCPM. …
Literature
1.
Ishigami H, Fujiwara Y, Fukushima R, et al. Phase III trial comparing intraperitoneal and intravenous paclitaxel plus S-1 versus cisplatin plus S-1 in patients with gastric cancer with peritoneal metastasis: PHOENIX-GC trial. J Clin Oncol Off J Am Soc Clin Oncol. 2018;36(19):1922–9.CrossRef
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Metadata
Title
ASO Author Reflections: Combination Intra-Peritoneal and Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastases
Authors
Daryl K. A. Chia, FRCS
Jia Jun Ang, MRCS
Raghav Sundar, MRCP
Guowei Kim, FRCS
Asim Shabbir, FRCS
Jimmy B. Y. So, MPH, FRCS
Wei Peng Yong, MRCP
Publication date
03-10-2022
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-022-12102-1

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