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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2021

01-03-2021 | Mastectomy | ASO Author Reflections

ASO Author Reflections: Residual Disease in the Breast After Neoadjuvant Chemotherapy Does Not Mandate Routine Post-Mastectomy Radiation Therapy/Regional Nodal Irradiation

Authors: Angelena Crown, MD, Monica Morrow, MD

Published in: Annals of Surgical Oncology | Issue 3/2021

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Excerpt

Post-mastectomy radiation therapy (PMRT) and regional nodal irradiation (RNI) improve survival among patients who are at high risk of locoregional recurrence (LRR). While PMRT/RNI is routinely recommended to patients with nodal metastases, the benefit of PMRT/RNI in node-negative patients remains poorly defined despite their inclusion in two randomized trials of PMRT/RNI.1,2 While data to inform decisions regarding PMRT/RNI following neoadjuvant chemotherapy (NAC) are limited, multiple studies, including the joint analysis of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-18 and B-27 trials, have identified absence of pathologic complete response (pCR) as a predictor of LRR.3 …
Literature
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Poortmans PM, Collette S, Kirkove C, et al. Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med. 2015;373(4):317–27.CrossRef
2.
Whelan TJ, Olivotto IA, Parulekar WR, et al. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373(4):307–16.CrossRef
3.
Mamounas EP, Anderson SJ, Dignam JJ, et al. Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27. J Clin Oncol. 2012;30(32):3960–6.CrossRef
4.
Yang TJ, Morrow M, Modi S, et al. The effect of molecular subtype and residual disease on locoregional recurrence in breast cancer patients treated with neoadjuvant chemotherapy and postmastectomy radiation. Ann Surg Oncol. 2015;22 Suppl 3:S495–501.CrossRef
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Swisher SK, Vila J, Tucker SL, et al. Locoregional control according to breast cancer subtype and response to neoadjuvant chemotherapy in breast cancer patients undergoing breast-conserving therapy. Ann Surg Oncol. 2016;23(3):749–56.CrossRef
6.
Metadata
Title
ASO Author Reflections: Residual Disease in the Breast After Neoadjuvant Chemotherapy Does Not Mandate Routine Post-Mastectomy Radiation Therapy/Regional Nodal Irradiation
Authors
Angelena Crown, MD
Monica Morrow, MD
Publication date
01-03-2021
Publisher
Springer International Publishing
Keyword
Mastectomy
Published in
Annals of Surgical Oncology / Issue 3/2021
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-09138-6

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