Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2021

01-02-2021 | Translational Research and Biomarkers

Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study

Authors: Yusuke Ishibashi, MD, Hironori Tsujimoto, MD, PhD, Takahiro Einama, MD, PhD, Satsuki Mochizuki, PhD, Keita Kouzu, MD, Shinsuke Nomura, MD, Nozomi Ito, MD, Manabu Harada, MD, Hidekazu Sugasawa, MD, PhD, Eiji Shinto, MD, PhD, Yoji Kishi, MD, PhD, Hideki Ueno, MD, PhD

Published in: Annals of Surgical Oncology | Issue 2/2021

Login to get access

Abstract

Background

Immunoinflammatory measures such as the neutrophil–lymphocyte ratio (NLR), the platelet–lymphocyte ratio (PLR), and the C-reactive protein (CRP)–albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. The current study investigated the correlation of NLR, PLR, and CAR with periostin expression in esophageal squamous cell carcinoma (ESCC).

Methods

The study retrospectively evaluated preoperative NLR, PLR, and CAR hematologically and POSTN immunohistochemically in 171 patients. The correlation of immunoinflammatory measures, POSTN expression, and survival outcomes was measured.

Results

The study showed a significant correlation of POSTN-positive expression with poor overall survival (OS) (P < 0.0001) and recurrence-free survival (RFS) (P = 0.03). The POSTN-positive group had higher PLR (189.6 ± 8 vs. 159.3 ± 12; P = 0.04) and CAR (0.36 ± 0.06 vs. 0.14 ± 0.09; P < 0.05) than the POSTN-negative group, whereas NLR did not differ between the two groups (3.27 ± 0.19 vs. 2.65 ± 0.28; P = 0.07). The uni- and multivariate analyses showed that POSTN-positive expression (hazard ratio [HR], 1.595; 95% confidence interval [CI], 0.770–3.031; P = 0.03), CAR (HR, 1.663; 95% CI, 1.016–2.764; P = 0.03), gender (HR, 2.303; 95% CI, 1.067–6.019; P = 0.03), and tumor depth (HR, 1.957; 95% CI, 1.122–3.526; P = 0.01) were independent prognostic factors.

Conclusions

Because POSTN-positive expression strongly correlates with immunoinflammatory measures, especially PLR and CAR, it is an independent prognostic factor in ESCC.
Literature
1.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.CrossRef
2.
Gupta B, Kumar N. Worldwide incidence, mortality and time trends for cancer of the oesophagus. Eur J Cancer Prevent. 2017;26:107–118.CrossRef
3.
Walsh S, Cook E, Goulder F, Justin T, Keeling N. Neutrophil–lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol. 2005;91:181–4.CrossRef
4.
Ishibashi Y, Tsujimoto H, Hiraki S, et al. Prognostic value of preoperative systemic immunoinflammatory measures in patients with esophageal cancer. Ann Surg Oncol. 2018;25:3288–99.CrossRef
5.
Kudo A. Introductory review: periostin–gene and protein structure. Cell Mol life Sci. 2017;74:4259–68.CrossRef
6.
Ohno F, Nakahara T, Kido-Nakahara M, et al. Periostin links skin inflammation to melanoma progression in humans and mice. Int J Mol Sci. 2019;20:169.CrossRef
7.
Deng X, Ao S, Hou J, Li Z, Lei Y, Lyu G. Prognostic significance of periostin in colorectal cancer. Chin J Cancer Res. 2019;31:547.CrossRef
8.
Brierley JD, Gospodarowicz MK, Wittekind C TNM Classification of Malignant Tumours. Oxford: Wiley; 2017
9.
Ando N, Kato H, Igaki H, et al. A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol. 2012;19:68–74.CrossRef
10.
Schisterman EF, Perkins NJ, Liu A, Bondell H. Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples. Epidemiology. 2005;16:73–81.CrossRef
11.
Shinto E, Tsuda H, Ueno H, et al. Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays. Lab Invest. 2005;85:257.CrossRef
12.
Ishibashi Y, Tsujimoto H, Yaguchi Y, Kishi Y, Ueno H. Prognostic significance of systemic inflammatory markers in esophageal cancer: systematic review and meta-analysis. Ann Gastroenterol Surg. 2019;4:56–63.CrossRef
13.
Chen M-F, Chen P-T, Kuan F-C, Chen W-C. The predictive value of pretreatment neutrophil-to-lymphocyte ratio in esophageal squamous cell carcinoma. Ann Surg Oncol. 2019;26:190–9.CrossRef
14.
Horiuchi K, Amizuka N, Takeshita S, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β. J Bone Miner Res. 1999;14:1239–49.CrossRef
15.
Underwood TJ, Hayden AL, Derouet M, et al. Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma. J Pathol. 2015;235:466–77.CrossRef
16.
Ma H, Wang J, Zhao X, et al. Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation. Cell Rep. 2020;30:793–806.e796.
17.
Moniuszko T, Wincewicz A, Koda M, Domysławska I, Sulkowski S. Role of periostin in esophageal, gastric, and colon cancer. Oncol Lett. 2016;12:783–7.CrossRef
18.
Koh S-J, Choi Y, Kim BG, et al. Matricellular protein periostin mediates intestinal inflammation through the activation of nuclear factor κB signaling. PloS One. 2016;11:e0149652CrossRef
19.
20.
Wang W, Sun Q-K, He Y-F, et al. Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7:593.PubMedPubMedCentral
21.
Jia W, Wang W, Ji C-S, et al. Coexpression of periostin and EGFR in patients with esophageal squamous cell carcinoma and their prognostic significance. Onco Targets Ther. 2016;9:5133.CrossRef
22.
Huang C, Yang G, Jiang T, Huang K, Cao J, Qiu Z. Effects of IL-6 and AG490 on regulation of Stat3-signaling pathway and invasion of human pancreatic cancer cells in vitro. J Exp Clin Cancer Res. 2010;29:51.CrossRef
23.
Tu B, Du L, Fan Q-M, Tang Z, Tang T-T. STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. Cancer Lett. 2012;325:80–8.CrossRef
24.
Walter M, Liang S, Ghosh S, Hornsby PJ, Li R. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene. 2009;28:2745–55.CrossRef
25.
Tsujimoto H, Ono S, Ichikura T, Matsumoto Y, Yamamoto J, Hase K. Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes? Gastric Cancer. 2010;13:212–21.CrossRef
26.
Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun. 2018;70:61–75.CrossRef
27.
Chen Z, Sun H, Yue B, Li JH. Expressions and clinical significance of periostin, VEGF, ET-1, and Hs-CRP in patients with acute coronary syndrome. Jiangsu Med J. 2013;39:929–31.
28.
Dixon MR, Haukoos JS, Udani SM, et al. Carcinoembryonic antigen and albumin predict survival in patients with advanced colon and rectal cancer. Arch Surg. 2003;138:962–6.CrossRef
29.
Kaysen GA, Chertow GM, Adhikarla R, Young B, Ronco C, Levin NW. Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients. Kidney Int. 2001;60:333–40.CrossRef
30.
Bologa RM, Levine DM, Parker TS, et al. Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients. Am J Kidney Dis. 1998;32:107–14.CrossRef
Metadata
Title
Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study
Authors
Yusuke Ishibashi, MD
Hironori Tsujimoto, MD, PhD
Takahiro Einama, MD, PhD
Satsuki Mochizuki, PhD
Keita Kouzu, MD
Shinsuke Nomura, MD
Nozomi Ito, MD
Manabu Harada, MD
Hidekazu Sugasawa, MD, PhD
Eiji Shinto, MD, PhD
Yoji Kishi, MD, PhD
Hideki Ueno, MD, PhD
Publication date
01-02-2021
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 2/2021
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08765-3

Other articles of this Issue 2/2021

Annals of Surgical Oncology 2/2021 Go to the issue

Translational Research and Biomarkers

Clinical Significance of Pretherapeutic Serum Squamous Cell Carcinoma Antigen Level in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma

Melanoma

Sentinel Lymph Node Biopsy Is Prognostic in Thickest Melanoma Cases and Should Be Performed for Thick Melanomas

Urologic Oncology

Nephron-Sparing Surgery for Adult Xp11.2 Translocation Renal Cell Carcinoma at Clinical T1 Stage: A Multicenter Study in China

Colorectal Cancer

The Landmark Series: Chemotherapy for Non-Metastatic Colon Cancer

Translational Research

Prognostic Significance of Circulating Tumor Cells with Mesenchymal Phenotypes in Patients with Gastric Cancer: A Prospective Study

Hepatobiliary Tumors

First Case of Full Robotic ALPPS for Intrahepatic Cholangiocarcinoma