Published in:
01-12-2020 | ASO Author Reflections
ASO Author Reflections: A Surgery-First Approach for Patients With Clinical Stage 1 Signet Ring Cell Gastric Adenocarcinoma
Authors:
Michael K. Turgeon, MD, Shishir K. Maithel, MD, Mihir M. Shah, MD
Published in:
Annals of Surgical Oncology
|
Special Issue 3/2020
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Excerpt
Signet ring cell histology is a relatively common variant of gastric adenocarcinoma that encompasses 35% to 40% of cases.
1 Historically, signet ring cell histology has been considered a more aggressive subtype associated with a worse long-term prognosis.
2 As a result, many clinicians favor the use of neoadjuvant or perioperative therapies to address the fact that patients may be clinically understaged and to target micrometastatic disease. However, current stage-specific data are sparse, and the optimal management strategy remains controversial. This study sought to assess the validity of a surgery-first versus a multimodality approach to clinical stage 1 gastric adenocarcinoma with signet ring cell histology.
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