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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2020

01-09-2020 | ASO Author Reflections

ASO Author Reflections: ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma

Authors: Keita Katsurahara, MD, Atsushi Shiozaki, MD, PhD, Eigo Otsuji, MD, PhD

Published in: Annals of Surgical Oncology | Issue 9/2020

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Excerpt

The anoctamin (ANO) family consists of transmembrane proteins in 10 isoforms, with ANOs being broadly expressed in epithelial and non-epithelial tissues.1 Of these, few studies have reported the function and activation mechanism of ANO9. Previous reports demonstrated that each subtype has either ion channel activity, scramblase activity, or both, but details on these functions are unknown. Recent studies revealed that ANO9 plays important roles in various cancers, such as colorectal cancer2 and pancreatic cancer;3 however, the roles of ANO9 in tumor progression in patients with esophageal squamous cell carcinoma (ESCC), and the clinical significance of its expression, remain unclear. The aims of the present study were to investigate the roles of ANO9 in the regulation of cancer growth and its clinicopathological significance in ESCC.4 …
Literature
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Schreiber R, Uliyakina I, Kongsuphol P, et al. Expression and function of epithelial anoctamins. J Biol Chem. 2010;285(10):7838–7845.CrossRef
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Li C, Cai S, Wang X, Jiang Z. Identification and characterization of ANO9 in stage II and III colorectal carcinoma. Oncotarget. 2015;6(30):29324–29334.CrossRef
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Jun I, Park HS, Piao H, et al. ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. Br J Cancer. 2017;117(12):1798–1809.CrossRef
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Kunzelmann K, Ousingsawat J, Benedetto R, Cabrita I, Schreiber R. Contribution of anoctamins to cell survival and cell death. Cancers. 2019;11(3):382.CrossRef
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Wanitchakool P, Ousingsawat J, Sirianant L, MacAulay N, Schreiber R, Kunzelmann K. Cl(-) channels in apoptosis. European biophysics journal 2016;45(7):599–610.CrossRef
Metadata
Title
ASO Author Reflections: ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma
Authors
Keita Katsurahara, MD
Atsushi Shiozaki, MD, PhD
Eigo Otsuji, MD, PhD
Publication date
01-09-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 9/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08370-4

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